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Biomedical subjects

A Martin

Publications and source records attributed to A Martin.

At least 775 records · Page 43Linked to original sources
PubMed1982

Trimethaphan-induced hypotension: effect on renal function.

This study was designed to evaluate the effects of trimethaphan-induced hypotension on renal function in healthy young patients undergoing maxillofacial surgery. Anaesthesia was induced with thiopentone and was maintained with halothane 1.5-2.0 per cent in oxygen. Each patient served as his own control, and data were analyzed using the paired t-test. Trimethaphan was infused at a rate of 45-52 microgram.kg-1.min-1 for an average hypotensive period of 53 +/- 4 (mean +/- SEM) minutes to reduce the mean arterial pressure (MAP) to 49 +/- 2 torr. Endogenous creatinine clearance, urinary Po2, sodium reabsorption rate (Tna), and serum and urine osmolalities were determined before, during and after arterial hypotension with trimethaphan. Urine flow averaged 2.9 +/- 1 ml/min during the period of hypotension. Endogenous creatinine clearance and Tna were significantly decreased (p less than 0.05) in the hypotensive period. These values returned to normal levels within one hour upon discontinuation of trimethaphan and restoration of blood pressure. We found no statistical difference in urine Po2, and serum and urine osmolalities during control, hypotensive and recovery periods. These results suggest that medullary renal tissue oxygenation, an index of tissue viability, may have remained adequate despite a significant reduction in endogenous creatinine clearance during the hypotensive period. Furthermore, it appears that the effect of trimethaphan-induced hypotension on renal function is similar to the sodium nitroprusside-induced hypotension in man which we have reported previously.

Anesthesia↗
PubMed1982

Characterization of a mannosyl-lipid compound of microsomal fractions of rat pancreas and influence of diet.

1. High-starch diet induces an activation of rat pancreatic microsomal mannosyl-transferase activity as compared with a standard diet or a high-fat diet. 2. This increase is found in a mannose-containing lipid which is identified as a dolichyl-phosphoryl-mannose on the criteria of DEAE-cellulose chromatography, alkaline and acid hydrolysis, thin-layer chromatography and identity of this endogenous product with the [14C]mannose-containing product synthesized in presence of exogenous dolichyl-monophosphate added to the incubation medium. 3. Kinetic parameters (Km and Vmax) of the enzyme versus polyprenic acceptor are not modified by the diet. 4. The results indicate that the activation of the mannose transfer is principally due to an increase of the polyprenic endogenous acceptor by the high-starch diet.

Animals↗
PubMed1982

Randomised placebo-controlled double-blind trial of two dosages of sodium cromoglycate in treatment of varioliform gastritis: comparison with cimetidine.

Eighteen patients with diffuse varioliform gastritis were enrolled in a double-blind, placebo-controlled trial of sodium cromoglycate, 200 mg a day, and sodium cromoglycate, 400 mg a day, for 28 days. An additional six patients were treated with cimetidine 1 g daily for 28 days. The improvement in terms of patient's subjective assessment, endoscopic assessment, and immunohistochemical measurements of IgE cells in the mucosa was significantly greater in patients given sodium cromoglycate than that in those given cimetidine or placebo. The results provide evidence that type 1 hypersensitivity plays some part in the pathogenesis of varioliform gastritis. It is, therefore, important to differentiate this condition from other types of gastritis, as treatment with sodium cromoglycate appears to be affective.

Cimetidine↗
PubMed1982

Asymptomatic gonorrhea: selective screening and guidelines for identification of high risk patients.

As recently as 1980, gonorrhea ranked first among communicable diseases in the U.S.A. More alarming was the fact that 75 to 80 percent of infected females were reported to be asymptomatic. As more of these asymptomatic individuals were discovered, the tendency to do routine gonococcal screening in women increased. Of late, however, the trend to abstain from doing routine gonococcal screening has become more evident because of the low yield of positive cultures in the majority of the population screened. The St. Joseph's Medical Center is a single residency (Family Practice) teaching hospital serving the community of Yonkers, N.Y. The St. Joseph's Family Health Center serves as the model unit where our residents work and is also the main outpatient facility of the hospital. The objective of our study was to determine the incidence of asymptomatic gonorrhea prospectively and randomly, in our female patients, to form guidelines to separate high from low risk patients, and to discuss the question of whether gonococcal screening should be performed routinely in females.

Female↗
PubMed1982

Pulse-cytophotometric investigations on cells of inflamed tissues.

In rats the degree of mitosis of cells in the peritonitis exudate was determined after injecting a mixture of carrageenin/formalin. The same determination was performed in the skin tissue of the adjuvant-injected hind paw during adjuvant arthritis. No significant change of the mitosis rate could be found. The present data suggest a maintainance of the inflammatory reaction by immigrating cells and not by cell division.

Animals↗
PubMed1981

Characterization by infrared spectroscopy of the bilayer to nonbilayer phase transition of phosphatidylethanolamines.

A Fourier-transform infrared spectroscopic study of the thermotropic behavior of egg yolk phosphatidylethanolamines is reported. Two phase changes were monitored, the gel to liquid-crystalline acyl chain melting transition, centered at 12 degrees C, and a transition from the liquid-crystalline to be inverted hexagonal phase, centered at 28 degrees C. It is demonstrated that the gel to liquid-crystalline phase transition results in a large increase in the conformational disorder of the acyl chains in the bilayer and that the nonbilayer phase contains a still higher degree of conformational disorder. It is shown that the transition to the inverted hexagonal phase is promoted by highly unsaturated acyl chains. A model is developed for the bilayer to nonbilayer phase transition in which it is proposed that the driving force which triggers this phase transition is the introduction of a degree of conformational disorder so high that the integrity of the bilayer surface can no longer be maintained, due to the volume requirements of the acyl chains. A number of previously reported data are rationalized in terms of this hypothesis.

Egg Yolk↗