Search PubMed⌕ Search

Biomedical subjects

A Marsh

Publications and source records attributed to A Marsh.

63 records · Page 4Linked to original sources
PubMed1980

Inter-relationships among hospitalization measures of psychiatric outcome.

In a diagnostically heterogeneous sample of 381 first admission male state hospital patients, no consistent correlations appeared among three commonly employed hospitalization measures of outcome. The possibility that psychiatric hospitalization may be a multidimensional criterion is considered and the implications for outcome research are discussed.

Follow-Up Studies↗
PubMed1979

Visual hallucinations during hallucinogenic experience and schizophrenia.

The visual hallucinations experienced by a 26-year-old woman under the influence of hallucinogens and during schizophrenia are described. Three types of hallucinations are delineated: (1) superimposed hallucinations, (2) spatial and depth distortions, and (3) animations. These three types of hallucinations appear to represent consecutive gradations on a continuum of the ego function of reality testing, with superimposed hallucinations revealing the least and animations the greatest degree of disorientation. The findings of the present study indicate the need for a research design that compares the hallucinations of schizophrenics to the toxic hallucinations of nonschizophrenics.

Adult↗
PubMed1979

Premorbid social competence and outcome among schizophrenic and nonschizophrenic patients.

The relation between premorbid social competence and outcome was examined with 381 male state hospital patients in four diagnostic categories: schizophrenia, affective reaction, psychoneurotic disorder, and personality disorder. Outcome was assessed using the measures of length of initial hospitalization, total length of rehospitalization, and number of readmissions. The follow-up period was 3 years after discharge from the first hospitalization. On all outcome measures, higher social competence was significantly related to favorable outcome. The four diagnostic groups differed significantly in social competence level, but no evidence was found to indicate that the social competence-outcome relation was influenced by diagnosis. Results were interpreted as consistent with a developmental formulation and as indicating that the relation between premorbid social competence and outcome is not unique to schizophrenia but obtains over a broad range of diagnoses.

Affective Symptoms↗
PubMed1977

Intravenous fat tolerance. Correlation with very low density lipoprotein apoprotein B kinetics in man.

The intravenous fat tolerance test (IVFTT) has been introduced as a measure of the fractional catabolic rate of the endogenous triglyceride of plasma. To assess the validity of this test we have compared this test in 21 normal and hyperlipidaemic subjects with direct measurement of the fractional catabolic rate of autologous radio-iodinated VLDL. There was a strong positive correlation between the rate constant K2 of the IVFTT and the fractional catabolic rate of VLDL-apolipoprotein B (r=+0.87). The two rates were considerably different in magnitude. The IVFTT appears to be a valid index of the fractional catabolic rate of VLDL. Its limitations and uses are discussed.

Adult↗
PubMed1975

A quenched-flow study of the reaction catalysed by creatine kinase.

The reaction catalysed by creatine kinase was studied in both directions by quenched-flow techniques to follow the initial product formation in the millisecond range. In both directions the amount of product formed increases linearly with time, and the turnover number corresponds to the steady-state value. Extrapolation to zero time indicates the absence of either a large transient phase or a large lag phase in both directions. This indicates that the actual chemical reaction is rate-limiting, and that all possible isomerizations before or after the chemical step must be much more rapid.

Adenosine Diphosphate↗
PubMed1972

Cholesterol turnover, synthesis, and retention in hypercholesterolemic growing swine.

Studies of the interaction of cholesterol absorption, excretion, synthesis, and retention were carried out with growing swine through the application of sterol and isotopic balance procedures to a non-steady state situation. The animals were fed either a low-fat commercial mash diet (MA), a commercial mash diet plus 2.4 g/day of crystalline cholesterol (MAC), or a high-fat milk diet containing 2.4 g/day cholesterol (MKC). [(14)C]Cholesterol and beta-[(3)H]sitosterol were used to measure fecal neutral steroid losses. Final plasma cholesterol levels averaged 91, 85, and 195 mg/100 ml for MA, MAC, and MKC animals, respectively. Total carcass dissection followed by cholesterol measurement revealed that accumulation of cholesterol in most body tissues was directly related to increase in body size in the rapidly growing swine. The only notable exceptions were plasma, liver, and bone with marrow of the MKC group, where cholesterol concentrations were significantly elevated. Absorption of cholesterol was significantly greater in animals fed MKC than MAC-fed swine (726 mg/day vs. 142 mg/day), whereas synthesis of cholesterol was significantly greater in MAC animals than in MKC animals (863 mg/day vs. 112 mg/day). Excretion of neutral and acid steroids into the intestine was not significantly different between MAC and MKC groups, but both classes of steroids were more efficiently reabsorbed in MKC animals. The overall differences between swine fed mash-cholesterol and those fed milk-cholesterol diets appear to result from more efficient absorption of both neutral and acid steroids in the milk-cholesterol group only partially compensated for by decreased cholesterol synthesis.

Animals↗