Biomedical subjects

A Marin

Publications and source records attributed to A Marin.

129 records · Page 8Linked to original sources

PubMedDate not supplied

[Ketotifen in childhood asthma].

In 1981 a double blind study was conducted at random with Ketotifen. Fifty children were chosen at random (40 males and 10 females) who had been diagnosed as suffering from extrinsic bronchial asthma and had not undergone any previous treatment either with sodium cromoglycate or with immunotherapy. In all cases the treatment lasted 12 weeks, with monthly controls, in some cases on a weekly basis, which measured the following parameters: Daily written control by the parents of the clinical evolution. Monthly clinical examination with cardiovascular control (Cardiac frequency, T A , etc.) respiratory examination with lung function study, auxomatric control (height, weight), etc. Monthly control of the additional medication received, specifying type of medication, dosage and length of time administered (bronchodilators, antihistamines, antibiotics, etc.). Monthly control of possible collateral and side effects: subjective symptoms: neurologic, digestive, dermatologic, psychic, neuro-vegetative, genito-urinary, cardiorespiratory, etc. Analytical control at the commencement and termination of treatment which consists of: a) complete blood cell count, b) platelets and c) hepatic function study (GOT, CPT and alkaline phosphatases). The results of the overall evaluation of the group of children submitted to treatment with active substances were as follows: In asthma 70.35% was VERY EFFECTIVE and EFFECTIVE and 29.61% SLIGHTLY or NOT EFFECTIVE. In dermorespiratory cases 57.13% was VERY EFFECTIVE or EFFECTIVE and 42.85% SLIGHTLY EFFECTIVE. In concomitant rhinitis 74.93% was VERY EFFECTIVE and EFFECTIVE and 25% SLIGHTLY EFFECTIVE.(ABSTRACT TRUNCATED AT 250 WORDS)

Asthma↗

PubMedDate not supplied

[Bronchial asthma in the 2d and 3d year of life].

In studying age of onset in our cases of extrinsic asthma, we found that symptomatology occurred in 50% of our patients before the age of 3, and in 45.2% between the first and third year of life. We are therefore concerned about children coming to our service after a long period of illness, since difficulty of recuperation correlates with the duration of asthma. When the onset of asthma is between the first and third years, the child is not yet familiar with his own body's function, and learns how to live as an asthmatic with decreased lung capacity in the intercritic period. As noted by Shepherd, the retention of mucus in a child's lungs will impair the respiratory function more than it does in the adult, since the lesion of an immature structure may hinder its normal development. It is therefore important at this age to maintain respiratory function. 242 children aged between 1 and 3 were studied, who suffered from obstructive respiratory syndromes whose etiology was determined by clinical history and immunoallergic parameters, both "in vivo" and "in vitro". The correlation between the RAST and skin test values by planimetry was also studied. 4 groups were distinguished according to the Foucard score: Group I: consisted of children with a clinical history suggestive of extrinsic allergic asthma due to house dust/mites, with positive skin tests and RAST positive 3-4. Group IIa: also suggestive of extrinsic allergic asthma, with positive clinical history, positive skin test and RAST O. Group IIb: with a positive clinical history, positive skin test and RAST 1-2. Group III: consisted of children with obstructive bronchitis, and uncertain clinical history, negative skin and inhalant tests and RAST O. Group IV: consisted of children with extrinsic asthma due to moulds, with a suggestive clinical history, positive skin tests and RAST 1-2-3-4. Diagnostic methods and therapy in the different groups are discussed. There is a high incidence of onset between the 2nd and 3rd year of age (45%). In the pediatric allergic service the incidence of onset in this age group is only 7.8%. Early diagnosis is essential to avoid damage to lung function in the intercritic period. Difficulty of diagnosis: in the 2nd year we found 38.4% positive and 15.5% suggestive results, totalling 53.9%; and in the 3rd year we found 45.7% positive and 6.2% suggestive results, totalling 51.9%, giving us a more than 50% possibility of extrinsic allergic asthma as the diagnosis.

Age Factors↗

PubMedDate not supplied

[Value of local cerebral hypoperfusion in the diagnosis of frontal syndromes. Importance in medical expert assessment of head injuries].

The importance of the symptoms linked to a frontal disorder in the intellectual and behavioral sequelas of severe cranial trauma, is now measured carefully because these troubles are one of the most important obstacle to the social and professional come-back. The handicap linked to a disorder of the frontal lobe is not well known in all its neurological, mental and sociological dimensions because the diagnosis is not easy. To help to this diagnosis, the study of cerebral blood flow with SPECT is usefull in medical practice. We present here 4 clinical cases of post-trauma frontal syndrome not easy to measure. With a measure of cerebral blood flow with SPECT, it was observed a decrease of frontal blood flow, that allowed to link the neuropsychological symptom to a frontal lobe disorder. It seems that in these conditions the post-trauma frontal syndrome is not so uncommon.

Adult↗