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Biomedical subjects

A Marin

Publications and source records attributed to A Marin.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Histoenzymatic activity of leucine aminopeptidase in normal bone marrow cells.

Human, monkey, cat and rat bone marrow cells were studied for the histochemical localization of leucine aminopeptidase activity. The granulocytes have a weak enzymic activity in the immature cells and a very strong one in the differentiated cells. The lymphopoiesis is characterized by a strong reaction in the lymphoblasts and different degrees of the enzyme activity in the lymphocytes. In the erythropoiesis, the undifferentiated cells are strongly positive, while the erythrocytes are negative. The immature and mature cells of the megakariocytic line show a weak leucine aminopeptidase activity.

Age Factors↗
PubMedDate not supplied

[Intraoperative ultrasonography during laparoscopic surgery].

AIM: Of this study is the introduction and the results evaluation of laparoscopic ultrasonography performed. MATERIAL AND METHOD: We realize a prospective study about laparoscopic ultrasonography performed in 37 cases with laparoscopic surgical treatment. The Aloka SSD 2000 mobile scanner is used. This system make possible the use of an linear-array transducer, with mechanical flexibility and availability of Doppler analysis. Most frequently we used intraoperative ultrasonography in laparoscopic cholecystectomy as an alternative for cholangiography to exclude CBD pathology. Because of various surgical pathology with laparoscopic approach, the laparoscopic ultrasonography utilization range was vastly. RESULTS: In all the cases we could performed the laparoscopic ultrasonography. In 6 of 27 cases with laparoscopic cholecystectomy we found pathological disorders of bile ducts. CBD with diameter found between 5-12 mm. We properly saw the distal segment of CBD in 23 cases (89.2%), and common hepatic duct in 26 cases (97.3%). The quality of visualization was very good in 21 cases (83.8%) and moderate in 6 cases (16.2%). We easy identify CBD stones and we successfully used Doppler color mode in differentiating vascular from non-vascular from non-vascular structures. Laparoscopic ultrasonography performed in a case with left colon cancer excluded liver metastasis and lymph nodes metastasis. CONCLUSIONS: 1. Laparoscopic ultrasonography combines the advantages of diagnostic laparoscopy and intraoperative contact ultrasonography; 2. Laparoscopic ultrasonography is a simple and very efficient intraoperative examination procedure; 3. Laparoscopic ultrasonography is the technique to choose in CBD intraoperative exploration; 4. Laparoscopic ultrasonography improve abdominal malignancy exploration, thus modifying therapeutic decisions; 5. Color Doppler mode guides the surgeon's steps in difficult directions.

Cholelithiasis↗
PubMedDate not supplied

[Mechanical suture in classic and laparoscopic general surgery].

AIM: Of this working is the study of employment the mechanical suture in general surgery classic and laparoscopic. MATERIAL AND METHOD: We analysed the possibility of accomplishment and postoperatory evolution of 104 mechanical sutures performed in 24 patients, with diverse surgery pathology, operated in Department of General Surgery, between January 1999 and January 2000. RESULTS: Mechanical sutures allowed us to minimize the duration of surgical interventions and to perform some difficult anastomotic assembles (sometimes including creation of organ substitute). We had only two postoperatory fistulas and two postoperatory haemorrhages from anastomotic area (both cases because of bad closing of clips, through tissue excess between anvil and cartridge of the stapler). CONCLUSIONS: There are certain advantages in using mechanical sutures (versus manual sutures) consisting in decreasing of time period, both in operation itself and in hospitalization, despite their high level cost.

Diverticulosis, Colonic↗
PubMedDate not supplied

[Laparoscopic choledochoscopy].

AIM: Of this study was to evaluate the treatment of common bile duct stones (CBDS) by laparoscopic choledochoscopy. MATERIAL AND METHOD: Between 1997-2002, 9 patients (with age between 42-75 years) were treated laparoscopic for CBDS: 8 cases with choledocholithiasis; 1 case with pancreatic neoplasm. Laparoscopic choledochoscopy was performed in 7 cases (84.4%). We used the choledochoscope Pentax of 5 mm diameter and with work canal. RESULTS: We performed the CBD exploration with: transcystic approach-1 case; choledochotomy-6 cases. The CBD diameter was between 1.2-1.5 cm. The bile duct stones diameter were between 0.5-1.5 cm. We performed with successfully the laparoscopic choledochoscopy exploration and extraction of CBD stones to all patients. External biliary drainage (transcystic duct and with Kehr-tube) were done systematically. The major complication (choleperitoneum) occurred in 2 cases (28.5%). The occurrence of residual ductal stones was 0. CONCLUSION: The laparoscopic treatment of choledocholithiasis is feasible, safe and efficient.

Adult↗
PubMedDate not supplied

[Consideration regarding 20 antireflux laparoscopic operations for hiatal hernia].

AIM: To evaluate the clinical, therapeutical and evolutive aspects of the patients with hiatal hernia with laparoscopical approach. MATERIALS AND METHODS: Retrospective analysis of 20 patients diagnosed with hiatal hernia and operated, laparoscopical, between 13.01.1999-10.04.2002. RESULTS: At 18 cases (90%), were sliding hiatal hernia and at 2 cases (10%), were paraesophageal hiatal hernia. There were performed laparoscopical: 1 (5%) Dor anterior hemi-fundoplication, 4 (20%) Rosetti fundoplication, 3 (15%) Toupet posterior hemi-fundoplication and 11 (55%) Nissen fundoplication. For the dissection, the ultrasound scissors (Ultra-Shears) was used and for the suture of the both diaphragmatic crus and the wrap, the Endo-Stitch. There were reported 1 (5%) optional conversion and 3 cases (15%) with bleeding solved by clipping and hemostatic suture. No postoperative complications, deaths intra and postoperative were reported. The average duration of the intervention decreased in time, due to the experience, from 180 to 60 minutes, but in accordance with the complexity of the procedure (Nissen-Toupet-Dor). At 2 (10%) cases with Nissen fundoplication was reported a transitory dysphagia, which was remitted between 1-2 months. We noticed a decreasing of the duration of hospitalisation for the antireflux laparoscopical interventions, compared with the classic methodes. CONCLUSIONS: There is a tendency of the laparoscopical approach of hiatal hernia to come the standard in the GERD, due to his minimal invasive character, significantly reducing costs and good postoperative results.

Adult↗
PubMedDate not supplied

[Intraoperative diagnosis of common biliary duct using laparoscopic ultrasonography].

THE AIM: Of the study is to show the advantages and limits of laparoscopic echography in exploration and diagnosis of common biliary duct lithiasis, as it is evidenciated in the experience of our surgical department. MATERIAL AND METHODS: Between 31.03.1997-31.12.2002 we have made 878 laparoscopic interventions to patients with hepatho-biliary pathology. We made a prospective study and performed 116 laparoscopic ultrasonography examinations for exploration of the liver and bile ducts. We used an Aloka SSD 2000 device with a linear laparoscopic flexible transductor. RESULTS: We obtained a very good visualization in 97 cases (83.6%) and medium visualization in 19 cases (16.4%). The medium time of the examination was 10 minutes (variations between 5-20 minutes). We discovered pathological modifications in principal bile duct and cystic using color Doppler examination in acute and chronic inflammatory lesions with important anatomical modifications. CONCLUSIONS: 1. laparoscopic ultrasonography it is an ideal technique in common bile duct lithiasis diagnosis, with 90-98% precision. 2. intraoperative ultrasonography does not need preliminary dissection of cystic and offers the possibility of exploration of the liver and pancreas. 3. it needs a learning curve and collaboration between surgeon and ultrasonography specialist.

Cholecystectomy, Laparoscopic↗
PubMedDate not supplied

[Peroral cholangioscopy].

The aim of this study was to present peroral cholangioscopic method, their technique, indications, contraindications, the advantages and disadvantages of this method. Peroral cholangioscopy is associated with ERCP and was developed in the last two decades by development of "mother & baby" endoscopic system. In same mode with percutaneous cholangioscopy or laparoscopic cholangioscopy, peroral cholangioscopy have an important role in diagnosis and therapy of common bile duct diseases. In 2001-2002 the authors have perform six peroral cholangioscopy for diagnosis and therapy (nonspecific radiological findings on ERCP) and in five cases, they have found choledochal lithiasis which was resolved by this way. In one case has not found any pathology. By their efficiency with a low rate of specific complications, peroral cholangioscopy is now an appropriate method in diagnosis and therapy of common bile duct disease.

Bile Ducts↗
PubMedDate not supplied

[Percutaneous endoscopic cholangioscopy (percutaneous cholangioscopy)].

The aim of this paper is to present the percutaneous cholangioscopic method, objectives, indications, technique and advantages of this method in exploration and treatment of common bile duct disease. Percutaneous cholangioscopy is a complementary mini-invasive method, which is associated to classic or laparoscopic surgical procedures on common bile duct disorder. This method has the main characteristic intraductal approach, which is made via an external preformed fistula derived from an anterior surgical open or mini-invasive interventional procedures performed on the common bile duct. Percutaneous cholangioscopy is very performing in early or differential diagnosis determination of common bile duct malignant tumors and is a valuable method for mini-invasive intraductal treatment that can be performed by this method, avoiding another interventional surgical or endoscopical procedure on common bile duct.

Cholangiography↗
PubMedDate not supplied

Histochemical study of leucine aminopeptidase in leukemia.

By means of a histochemical method, the leucine aminopeptidase activity was studied in human normal and leukemic peripheral blood. Before administration of cytostatics the enzymic activity was high in the cytoplasm of blasts and in the nuclei of segmented cells. After therapy the activity of leucine aminopeptidase in blasts decreased, while in polymorphs it became negative in nuclei and positive in their cytoplasm. The non-granular leukocytes and platelets displayed a weak enzymic activity both in normal and malignant blood cells. The erythrocytes were negative.

Antineoplastic Agents↗
PubMedDate not supplied

[Effects of callosotomy in the treatment of intractable epilepsies in children on psychiatric disorders].

Two children, 13 and 14 years old, presented an intractable epilepsy of Lennox-Gastaut. In front of dangerous tonic and atonic epileptic crisis, a corpus callosotomy was performed. Corpus callosotomy is becoming a more widely used procedure in the treatment of intractable epilepsy as Lennox-Gastaut syndrome, or frontal epilepsy. However, there have been very few series that have reported results in children. It is not a complete but a partial, callosal section including approximately the anterior two thirds of the callosum. After this surgery the two children improved dramatically because the dangerous tonic and atonic crisis disappeared. Secondly we observed improvement of pre-surgical psychiatric troubles, that is a data not developed in the literature. Before surgery, the two children had a frontal syndrome with hyperkinesia, distractibility, aggressiveness, alexithymia, loss of the program of ideas. During the two months after the section of the anterior two thirds of the corpus callosum, we observed a progressive improvement of the frontal syndrome, with possibility to learn new praxies. The intellectual quotient was not altered and associative functions, depending of the posterior third of the corpus callosum were spared. Anti-epileptic medications were not stopped. We think that the improvement of the frontal syndrome is due to reduction of seizures. Therefore, we insist on the interest of the section of the anterior two thirds of the corpus callosum as treatment of tonic and atonic seizures but also as treatment of psychiatric symptoms depending of a frontal syndrome.

Adolescent↗
PubMedDate not supplied

Chronic erosive arthritis associated with an unusual intestinal bypass.

We describe an unusual intestinal bypass arthritis in a 37-year-old man. The intestinal bypass was unusual because the intestinal blind loop was entirely composed of colon. The arthritis was first a typical bypass arthritis but later resembled rheumatoid arthritis. In spite of this resemblance, all rheumatic symptoms disappeared after jejunocaecal reanastomosis.

Adult↗
PubMedDate not supplied

[Advances in dentistry].

After a long period of research, a lot of elements of high technology have come to dentistry. Intraoral camaras, magnetic resonance imaging devices, digital radiographic equipment, laser, and computer systems that custom, mill and place restorations. The future evolution of all these devices, could be spectacular, considering its numerous possibilities in dental field.

Dental Equipment↗
PubMedDate not supplied

Molecular electrostatic potential-anthelmintic activity relationships of 5H-mebendazole and some related heterocyclic carbamates.

5H-Mebendazole and some related heterocyclic methyl carbamates were synthesized and their anthelmintic activity against Caenorhabditis elegans was determined. In order to study the influence of the heteroaromatic region with regard to the carbamate moiety on biological activity, the molecular electrostatic potentials (MEP) of all structures were calculated and a structure-activity relationship (SAR) was established. The electrostatic pattern of activity includes two minima of the carbamate moiety, a third heterocyclic minimum, and a pi-electronic region.

Animals↗
PubMedDate not supplied

Monosodium glutamate and skin pathology in pediatric allergology.

This study presents the cases of five children who consulted us because of skin pathology, in which a hypersensitivity to monosodium glutamate (MSG) was detected. In four children, the motive for consultation was urticaria; in two children, urticaria was accompanied by angioedema, while the fifth child presented with atopic dermatitis and urticaria. In the four cases of urticaria, the etiological diagnosis was probable drug allergy. The oral provocation test (OPT), carried out with monosodium glutamate (MSG) in opaque capsules containing 50 and 100 mgr., was positive in two hours in four of the five children. MSG's mechanism of action is unknown, and though its use is world-wide, no evidence of hypersensitivity with cutaneous symptomatology has been found in any of the studies carried out to date.

Administration, Oral↗