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Biomedical subjects

A Marchevsky

Publications and source records attributed to A Marchevsky.

At least 55 records · Page 3Linked to original sources
PubMed1982

The spectrum of pathology of nontuberculous mycobacterial infections in open-lung biopsy specimens.

The diagnosis of pulmonary nontuberculous mycobacterial (NTM) infection may be difficult to establish unless open-lung biopsy is performed. Mycobacteria were present in resected lung tissues from forty patients at the Mount Sinai Hospital during the period 1969-1980. M. avium-intracellulare was cultured in 24 patients, M. tuberculosis in six, M. gordonae in three, and M. fortuitum in two. In five instances, mycobacteria were seen in smears of lung tissues but failed to grow in culture. Three distinct clinicopathologic groups of patients with NTM were recognized. (1) Eighteen patients had solitary pulmonary nodules resected with the clinical diagnosis of lung cancer. Histologically, they exhibited granulomas with varying degrees of necrosis. Mediastinal lymph nodes had no granulomas, except in one case. (2) Seven patients presented with roentgenologic evidence of bilateral, diffuse interstitial infiltration. M. avium-intracellulare or M. gordonae were isolated from lung tissue which histologically showed interstitial fibrosis and organizing pneumonia. In only one instance a few non-caseating epitheloid cell granulomas were found. Three of these patients had underlying malignancies treated with chemotherapy and one other had arthritis. The other three had no underlying diseases. (3) Three patients had multiple discrete infiltrates on chest roentgenograms. M. avium-intracellulare was isolated from their lung tissues. One of these patients exhibited necrotizing granulomatous vasculitis indistinguishable from Wegener's granulomatosis. It is apparent that classical "tuberculosis-like" granulomatous reaction is the most common histologic pattern but should not be expected in all patients with NTM infections.

Biopsy↗
PubMed1982

Quantitative studies of argyrophilic APUD cells in airways: II. The effects of transplacental diethylnitrosamine.

The effects of transplacental administration of diethylnitrosamine (DEN) on the densities of epithelial and APUD cells in the large and small airways of developing hamsters have been studied quantitatively. The APUD cells are quantitated by relating them to the number of airway epithelial cells; APUD cells are present in similar densities in the large airways (0.12 APUD cells/100 cells) and small airways (0.14) of 2-day-old control hamsters. At 4 days an increase in the densities of APUD cells and an increase in epithelial cells is observed in the small airways, whereas those in the large airways decrease slightly. At later periods there is a progressive decline in the density of APUD cells in the control hamsters. Exposure in utero to DEN results in a generalized increase in APUD cells in 2-day-old hamsters, which is more pronounced in bronchioles (fivefold increase). The effect disappears in older animals. It also results in a transient increase in tracheal epithelial cell density in 7-day-old hamsters. Whether the selective and transient APUD cell hyperplasia induced by transplacental administration of DEN results from proliferation of these cells or from differentiation of other types of epithelial cells into APUD cells requires further study.

APUD Cells↗
PubMed1981

Oncocytic carcinoid of lung: an ultrastructural analysis.

A 52-year-old man with a typical carcinoid tumor of the lung in which the tumor cells displayed marked oncocytic metaplasia is presented. The clinicopathologic and ultrastructural differences with so-called oncocytic of the lung are discussed. The potential of Kulchitsky cell derivatives to undergo oncocytic metaplasma is documented ultrastructurally.

Carcinoid Tumor↗
PubMed1980

Immunofluorescent studies of the eye in Waldenström's macroglobulinemia.

The eyes of a 53-year-old woman with K light chain macroglobulinemia were studied histopathologically. Retinal hemorrhages were observed on gross examination. Microscopic examination disclosed eosinophilic, PAS-positive deposits in cystoid spaces within the outer plexiform layer, in the inner retina, and about photoreceptors. Immunofluorescent studies showed that the deposits contained IgM. Aneurysmal dilations of small retina vessels were demonstrated as well.

Eye↗
PubMed1978

Pathology of the Lens in Down's syndrome.

A pathological study of the lenses of 21 patients with Down's syndrome disclosed no distinctive abnormalities of the lens capsule, as had been reported previously. Five patients, 15 years of age or older, had focal cortical changes consistent with the characteristic flake-like opacities seen in patients with Down's syndrome after the first decade of life. Three patients with more extensive, visually significant lens opacities showed nonspecific cataractous changes. No abnormalities other than pathological artifacts were seen in the lenses of patients younger than 15 years of age.

Adolescent↗
PubMedDate not supplied

Partial molar transformation of the placenta of presumably monozygotic twins.

A pregnancy with one normal female fetus and a placenta that was divided into halves, one normal the other molar, is described. Genetic analysis shows the molar component to be hyperdiploid/tetraploid but having an identical DNA composition as the normal twin. Because there was no trophoblastic proliferation and the hyperdiploid cells were confined to the villous stroma, and because the molar component was still being perfused by diploid vessels from the normal twin, we believe the mole is derived from polyploidization of the mesenchymal epiblast in a monozygotic twin pregnancy.

Adult↗