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Biomedical subjects

A Marcelli-Barge

Publications and source records attributed to A Marcelli-Barge.

At least 37 records · Page 2Linked to original sources
PubMed1984

Genetic polymorphism of the fourth component of complement and type 1 (insulin-dependent) diabetes.

The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p less than 0.00001); C4BQ0 was more frequent in propositi than in non-affected siblings (40 out of 74 versus 36 out of 92, p less than 0.05). When comparing the distribution of the phenotype C4BQ0 in Type 1 diabetic patients and normal control subjects, the difference was significant in patients bearing DR3 or DR4 (56% and 25%, respectively, p less than 0.003). The main linkage disequilibria were observed among the 74 propositi: B18, BfF1, C4, A3, BQ0, DR3; B12, BfS, C4, A3, BQ0, DR4. The existence of a silent allele at the C4 B locus is known to be associated with a defective immune response.

Complement C4↗
PubMed1984

[Preliminary study of HLA markers in French Catalonia].

Forty-two sets of parents and their two children, who had their origins for at least three generations in French Catalonia, were studied for HLA-A,B,C,DR and Bf alleles of the Properdine complement factors. Four haplotypes were observed to be in strong linkage disequilibrium (p less than 10(-3)): A1, Cw7, B8, DR3; Aw30 (Cw5), B18, BfF1, DR3; A1 (Cw6), B17; A29 or Aw23, Cw4, B12, BfF, DR7. The observed linkage disequilibria of these haplotypes in the French Catalonian population were compared with those already described among populations from the Basque country, the Toulouse area and Spanish Catalonia.

Adult↗
PubMed1984

Distribution of HLA-A,B alleles in 13 panels of blood donors in France.

In this study, we analysed 13 samples of the French population--4147 non-related individuals living in Bordeaux, Brest, Caen, Dijon, Limoges, Lyon, Marseille, Nancy, Paris, Poitiers, Rennes, Strasbourg and Toulouse--all of whom were typed for 10 alleles of the HLA-A locus and 16 alleles of the HLA-B locus. The results showed a strong heterogeneity (chi 2 = 675.13 for 324 df, p less than 10(5)). A diagram has been drawn up, showing the matrix of genetic distances obtained thanks to the B2 of Balkrishnan & Sanghvi (1968). This diagram enables us to envisage the hypothesis of 6 homogeneous clusters. A partition of chi 2 was used to test this 6 luster hypothesis: Paris and Caen (p = 0.98); Nancy, Strasbourg (p less than 5%); Rennes, Brest (p less than 1%); Dijon, Lyon, Marseille (p = 0.89); Limoges, Poitiers (p = 0.18); Toulouse, Bordeaux (p less than 10(-5)). The heterogeneity within these clusters represents only 1/43 of the total heterogeneity.

Alleles↗
PubMed1984

HLA-A, -B and -C specificities in a sample of the Nile Delta population, Egypt.

HLA-A, -B and -C specificities were determined in 100 Egyptians living and originating from the region of the Nile Delta. The pattern of antigen frequencies were similar to those of Berber populations living in North Africa with some exceptions compatible with the Semitic contribution to the Egyptian population.

Egypt↗
PubMed1984

HLA-DR genotype risks in seropositive rheumatoid arthritis.

We studied the distribution of HLA-A, B, C, and -DR antigens in 77 Caucasian patients with sero-positive rheumatoid arthritis. Forty-four patients were genotyped and compared with the control panel of 110 unrelated Caucasian genotyped donors. The data obtained confirm the association of DR4 with RA, and reveal an increased risk of disease for patients carrying DR1, DR2, and DR3, compared to the risk for those carrying other antigens, such as DR5, DRw6, and DR7. There is a higher risk for DR4/4 homozygotes than for DR4/1, DR4/2, or DR4/3 heterozygotes. DR4/5, DR4/6, and DR4/7 have a lower risk than the previously mentioned genotypes. The genotype risks are compatible with the inheritance of a single, linked genetic determinant of disease susceptibility, but we are unable to distinguish between recessive and dominant inheritance of susceptibility using the "antigen-frequencies-amongst-diseases" method. DR4 seems to be more frequent in patients in whom onset occurs before the age of 35 (79% vs. 54% DR4 positive). A significant excess of DR3 + is observed in patients with toxic complications following treatment with gold salts (X2(1) = 8.96).

Adult↗
PubMed1983

[Anti-glafenine circulating antibodies: demonstration and frequency in acute renal insufficiency following intake of glafenine in toxic doses].

From 1970 to 1981, acute glafenineeeeeeee poisoning was observed in 106 patients, including 37 with acute renal insufficiency (ARI). From 1977 to 1982, the search for anti-glafenin antibodies was carried out systematically by direct and indirect tests for antiglobulin on erythrocytes, and by leucoagglutination and complement fixation tests on platelets in the presence of glafenin. An antibody was detected in only one of the 17 ARI patients studied. This antibody, IgM, has been studied along with glafenin, floctafenin, antrafenin and their metabolites. The rareness of such an antibody confirms the direct nephrotoxic action of glafenin, a drug responsible for half of the renal insufficiencies observed in an intensive care unit specialized in toxicology.

Acute Kidney Injury↗
PubMed1983

[Immunologic diagnosis of rheumatoid polyarthritis using a new micromethod of quantitative hemagglutination of the rheumatoid factor: the polyartiter].

A new micromethod of quantitative haemagglutination of the rheumatoid factor (class IgM) "polyartitre" was studied and compared with the classical Waaler-Rose reaction to the polyartest and to the rheumalatex using sera from 40 patients with rheumatoid arthritis, confirmed both radiologically and clinically. Thirty controls were selected from among the blood donors and 29 subjects with viral infections, hepatic or systematic illnesses or metabolic troubles. This method presents an excellent concordance with other methods. It is quantitatively more sensitive as the rheumatoid factor titres are higher than those obtained with the classical Waaler-Rose reaction. The polyartitre is simple to perform, easy to read, specific and reproducible, and the results are expressed in international units.

Arthritis, Rheumatoid↗
PubMed1983

Age--related heterogeneity of insulin-dependent diabetes mellitus.

One hundred and thirty-three insulin-dependent diabetic (IDD) patients were genotyped for HLA-A, B, C, DR and 123 of them for Bf. The study shows a relationship between these genes and the age of onset of diabetes and emphasizes the possible heterogeneity of the disease. When patients under the age of 0 years at the onset of the disease were compared with those aged 11 to 29 years, a significant excess of HLA-B18 (41% versus 15%, p less than 0.001) and BfF1 (40% versus 21%, P less than 0.05) was observed. The haplotype B18, BfF1 was also more frequent in the first group of patients (haplotype frequency 18% versus 6%, p less than 0.02). The frequency of the whole haplotype Cw5, B18, BfF1, DR3 and of its segment BfF1, DR3, and the strength of the gametic associations between these alleles were much higher in IDD patients than in non-diabetic controls, irrespective of the age of onset of their diabetes. The association between early age of onset of IDD and the B18, BfF1 haplotype independently of DR3 (no association between age and DR3) suggests that a factor influencing the onset of the disease in young children could be under the control of (1) gene (s) in linkage disequilibrium with B18 and/or BfF1.

Adolescent↗
PubMed1982

HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.

R4 heterozygotes was observed. By contrast, the observed frequency of patients homozygous for DR3 or DR4 was not increased, but even slightly decreased. The data support a model of inheritance comprising at least two closely linked specifically "diabetic" loci (most of the time marked by B18, BfF1, DR3 and B15, BfS, DR4) and a non-specifically "diabetic" haplotype favouring auto-immunisation (most of the time marked by B8, BfS, DR3). This model is discussed in the light of the presented data and of those of the literature.

Adolescent↗
PubMed1982

Cerebro spinal fluid C2 and HLA system in multiple sclerosis.

C3 hemolytic activity has been measured in serum and C.S.F. of 67 multiple sclerosis (M.S.) patients classified in three evolutionary groups according to the index of progression of the disease and tested in HLA-A, B, C, DR and Bf. The median level of serum C2 is normal whether it is of the evolution or the HLA type. The average level of C.S.F. C2 is the same in the evolutionary groups and is low in patients bearing B 18 allele or B 18, DR2 haplotype. It seems that the median level of C.S.F. C2 is linked to the HLA types associated to the susceptibility gene(s) of the disease.

Alleles↗
PubMed1981

HLA-A,B,C, Bf and glyoxalase I polymorphisms in a sample of the Kabyle population (Algeria).

HLA (A,B and C) gene and haplotype frequencies were determined in 44 Berber families from the Kabyle tribe. The Bf and Glo polymorphisms were also defined and the haplotypes were deduced from these family data. The main association (A1, B8, BfS; A29, B12, Glo2, Aw33, B14, BfS, Glo1; Cw5, B18, BfF1; A1, Bw17) showed the relationship between the populations from the southwest of Europe, and this population. Another association, A11 and Bw21, was found also in Twareg, which are probably of the same origin.

Adult↗
PubMed1980

HLA genotype studies in juvenile insulin-dependent diabetes.

HLA genotypes were ascertained in 53 French Caucasian families, comprising 68 juvenile onset insulin-dependent diabetic siblings. Among the 49 alleles detected at different loci in the HLA complex (A, C, B, Bf, DR) 4 appeared to occur at a significantly higher frequency among the 53 index cases than in a control series of 116 healthy individuals: HLA-B18 (p < 10(-3)), DRw3, DRw4 and BfF1 (p < 10(-6)). The excess of HLA identical affected siblings confirms genotype disequilibrium and supports the hypothesis of an HLA-linked gene(s) conferring susceptibility. There was no increase of homozygosity for HLA DRw3 and DRw4 whereas there was a marked excess heterozygosity for HLA DRw3/DRw4 in diabetic patients (32% versus 0% in the control series, p < 0.001). These data provide evidence for the existence of two cooperating genes, linked to each of the HLA DR alleles.

Alleles↗
PubMed1980

An immunochemical study of the lymphocyte A, Atri system.

The anti-Atri lymphocytotoxic antibodies reacting only with 5.19% of A, ABH-secreting individuals have been tested by an inhibition assay with 19 oligosaccharidic structures carrying the A, B, H or Lewis structures. The inhibitions observed dissociate the A and H blood group substances from the Atri substance, and seem to indicate the role of fucosyl residues, particularly that of fucosyl alpha (1 leads to 3), which may be the immunodominant of the Atri substance.

ABO Blood-Group System↗
PubMed1979

Role of Ia-like products of the main histocompatibility complex in conditioning skin allograft survival in man.

This report correlates the survival time of 93 intrafamilial skin allografts performed under conditions of main histocompatibility complex (HLA) haploidentity with donor-recipient compatibility for products of the HLA-A, -B, -C, and -DR, as well as C3 proactivator, Glyoxalase I, and P loci located on the human 6th chromosome. Incompatibilities for HLA-A and -B (and to a lesser extent for HLA-C) and(or) for HLA-DR products exerted a strong influence upon the fate of skin allografts. When HLA-A and -B were considered alone, the most compatible group of grafts had a mean survival time of 15.8 d, as compared with 11.3 d for the most incompatible transplants. HLA-DR compatibility alone was associated with a mean survival time of 15.3 d, whereas HLA-DR-incompatible grafts had a mean survival time of 11.5 d. Incompatibilities for C3 proactivator, Glyoxalase I, and P did not have a significant effect upon graft survival. There was no evidence of an association between donor-recipient incompatibility at HLA-A, -B, or -C or at HLA-DR; such incompatibilities occurred independently of each other, in spite of the state of linkage disequilibrium known to exist between HLA-B and -DR. Incompatibilities for HLA-A, -B, and for HLA-DR exerted a potent additive effect upon graft survival. Skin grafts bearing one, two, or three incompatibilities had a mean survival time of 16.2, 13.7, and 10.7 d, respectively (P <0.0005).The results point to the important role played by the Ia-like products of the HLA complex (HLA-DR) in conditioning skin allograft survival in man. This consideration may be of direct relevance to the potential clinical usefulness of in vitro serological techniques for the detection of donor-recipient compatibility for HLA-DR.

Female↗