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Biomedical subjects

A Mansat

Publications and source records attributed to A Mansat.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Sperm morphology in fertile men and its age related variation.

The different kinds of abnormalities of spermatozoa and their age related variations are studied in a population of 214 fertile men. Coiled tails (7%), bent tails (5.2%), thin heads (2.6%), microcephalic (2.6%), cytoplasmic droplets (2.5%), irregular heads (2%), macrocephalic (0.9%), duplicated heads (0.7%) and duplicated tails (0.5%) are found in this order. Age is positively correlated with the percentage of microcephalic, macrocephalic and duplicate heads and coiled tails and negatively correlated with the percentage of no tail spermatozoa: these age-related variations are involved in the 90th percentile.

Adult↗
PubMedDate not supplied

[Plasma concentrations and urinary excretion of gonadotropins in azoo and oligospermia. Relationship with spermatogenesis and plasma concentration of androgens (author's transl)].

Plasma concentrations and urinary excretions rate of gonadotropins, testosterone, delta 4-androstenedione, dehydroepiandrosterone and 17 and 17 alpha-hydroxyprogesterone plasma concentrations have been studied in 69 patients with oligo or azoospermia and compared with results obtained in 30 normal control subjects. A sperm count and a caryotype have been done in all patients and a testicular biopsy in 35. Analysis of the histo-hormonal correlations does not show a particular stage of spermatogenesis associated with a modification in FSH production. There is a quantitative relationship between spermatogenesis and FSH production. Plasma testosterone is low and LH production normal in excretory azoospermia. In the other patients plasma testosterone is also low but associated with an increased production of LH. Finally there is a direct relationship between urinary excretion of LH and FSH in both normal subjects and patients, suggesting a modulation by specific factors of a common regulation of the secretion of both gonadotropins.

Adult↗
PubMedDate not supplied

[A computerised study of 124 cases of varicocoele which were operated on for diminished fertility. General features (author's transl)].

A computerised study has been carried out on the general features of a clinical, biological and histological nature occurring in 124 varicocoele cases that were operated. These features were furthermore studied in correlation with the degree of varicocoele in existence and whether characteristics were found in isolation or in association with one another. The authors conclude that there were significant correlations between the degree of varicocoele present and the hormonal and histological findings. They advance a theory about the transport of testosterone in the spermatic cord which can explain the low level of testosterone found in the blood in these varicocoeles.

Adult↗
PubMedDate not supplied

[Treatments of testicular cancer and protection of spermatogenesis].

The deleterious effects of chimio or radio-therapy on spermatogenesis of men treated for testicular cancer are well known. Retroperitoneal lymphadenectomy is a risk for ejaculation process. Semen cryopreservation seems to be obligatory before any deleterious treatment. Prophylactic measures do exist such as lead protection during x-rays therapy, drugs with less toxicity but similar efficiency, selective lymphadenectomy. Moreover, positive results were reported form realised in animals to protect spermatogenesis. In men treated for testicular cancer, 4 protective studies were reported using either GnRH analogs (3 studies) or medroxyprogesterone (one study). No protective effects were obtained in these trials, and the reasons for such failure are discussed. Finally, new potential possibilities of spermatogenesis protection are suggested supported by the results of animal experiments or the occurrence of new drugs such as use of steroids, GnRH antagonist or testicular hypothermia.

Antineoplastic Agents↗