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Biomedical subjects

A Manoli

Publications and source records attributed to A Manoli.

At least 73 records · Page 4Linked to original sources

Skeletal changes associated with copper deficiency.

Copper deficiency has been described in premature infants on hyperalimentation. The bony abnormalities are generalized and are usually associated with anemia and neutropenia. These changes present with normal serum levels of iron, ascorbic acid, calcium, phosphorus, and magnesium, as well as with depressed levels of copper and ceruloplasmin. They appear at about three to nine months of age in infants with a low birth weight who are receiving total parenteral nutrition, but can be prevented by greater than normal maintenance levels of copper supplements. Established bone changes improve rapidly after the administration of therapeutic supplements.

Copper↗

Treatment of femoral neck fractures with the sliding compression screw.

Twenty-nine patients with intracapsular fractures of the femur were treated with a sliding compression screw. The overall incidence of unsatisfactory results was 48%. In the combined group of Garden III-type and Garden IV-type fractures, 58% had unsatisfactory results. The Garden IV type fractures, considered separately, had 89% unacceptable results. The most significant factors associated with an unsatisfactory result were: (1) poor reduction; (2) poor alignment or depth of the screw; and (3) the use of the long threaded lag screw. Inability to control the proximal fragment during the procedure made it difficult to maintain satisfactory reduction and may have contributed to avascular necrosis in seven of the 29 hips. Displaced fractures of the femoral neck are difficult to reduce and transfix. The sliding compression screw did not compensate for a technically poor reduction or unsatisfactory surgical placement of the device.

Bone Screws↗

Wound botulism.

Wound botulism, a potentially fatal disease, presents with signs and symptoms of food-borne botulism without the gastrointestinal manifestations. All cases have been associated with extremity wounds. The diagnosis is clinical, and aggressive ventilatory support is the cornerstone of successful therapy. A case is reported and the pathophysiology, diagnosis, and treatment are reviewed.

Adult↗

Fractures of the humerus in arm wrestlers.

In 7 cases of fracture of the humerus occurring in arm wrestlers, each patient sustained a simple spiral fracture of the distal third of the humerus. No patient had any neural or vascular compromise. Three patients underwent open reduction and internal fixation with 2 screws, at which time, muscle was found to be interposed between the fracture fragments. The other 4 patients were treated in hanging arm casts. All of the fractures united. Of the 41 cases of this injury reported in English medical literature there were 5 patients with radial nerve palsy and 16 patients who had had operative treatment of the injury. Because of the possibility of participants sustaining such an injury, arm wrestling should not be considered a totally benign sport.

Adult↗

Single versus double screw fixation for treatment of slipped capital femoral epiphysis: a biomechanical analysis.

Slipped capital femoral epiphyses (SCFE) were created in 10 pair of bovine femurs. Each pair was pinned with a single screw on one side and two screws contralaterally. The specimens were reloaded to failure. Double pin fixation yielded only a 33% increase in stiffness as compared with single pin fixation. Resistance to further slip was not proportional to screw number. The stiffness of neither double nor single screw fixation approximated that of the intact physis. Single screw fixation in slipped epiphyses is recommended because the small gains in stiffness with a second screw do not offset the risk of complications.

Animals↗

Report on the 1989 American Orthopaedic Foot and Ankle Society Fellow Scholarship.

In 1989, the American Orthopaedic Foot and Ankle Society, Inc., sponsored a scholarship for a member to return to training to do a fellowship in foot and ankle surgery. The following is the account of Arthur Manoli, II, M.D., who served 3 months with Sigvard T. Hansen, Jr., M.D., at the Harborview Medical Center, University of Washington, Seattle, Washington, and 9 months with Marion C. Harper, M.D., at Vanderbilt University, Nashville, Tennessee.

Education, Medical, Continuing↗

Calcaneal fracture after cortical bone removal.

Four patients developed calcaneal fractures while walking, soon after bone removal from the undersurface of the calcaneus. Heel spur or osteomyelitic bone removal can lead to this complication.

Adult↗