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Biomedical subjects

A Manitius

Publications and source records attributed to A Manitius.

At least 19 recordsLinked to original sources
PubMed1994

[P1 blood group, secretion status and susceptibility to asymptomatic bacteriuria in diabetes].

Blood-group antigens found on uroepithelial cells and in the secretions may affect bacterial adherence and thereby the predisposition to urinary tract infection. We determined P1, Lewis-blood-group phenotype and secretor status in patients with diabetes mellitus: 12 with asymptomatic bacteriuria and 7 without its presence. There was no difference between the two groups in the distribution of the P1 phenotype. There was also no statistical difference in the distribution of the Lewis phenotype and secretor status, although there appeared to be general trend of higher number of Le (a+b-) phenotype and non-secretors present in the asymptomatic bacteriuria group. Further studies are necessary to determine the role of blood groups and secretor status in the pathogenesis and susceptibility to urinary tract infection.

Adult↗
PubMed1994

Effect of epinephrine infusion on plasma potassium and its urinary excretion in rats subjected to subtotal nephrectomy.

Extrarenal potassium handling plays pivotal role in potassium homeostasis and is regulated by several hormones including epinephrine. The aim of this study was to look how epinephrine affects both extrarenal and renal potassium handling in rats with chronic renal failure. In subtotally nephrectomized rats, epinephrine (0.05 micrograms/kg per h) plus KCl (0.5 mmol/kg per h) were infused i.v. Plasma potassium and its fractional urinary excretion were measured simultaneously in five clearance periods. Each clearance period lasted 20 min and glomerular filtration rate was estimated as inulin clearance. Regardless of epinephrine infusion plasma potassium as well as fractional potassium excretion were higher in rats with chronic renal failure than in controls (shame--operated). It was concluded that the effect of epinephrine on both extrarenal and renal potassium handling was ameliorated in rats with chronic renal failure.

Animals↗
PubMed1992

[Effects of alpha and beta receptor blockaders on urinary excretion of sodium and potassium in healthy rats and in those with chronic renal failure].

The aim the study was to investigate the effects of both alpha and beta adrenergic blockade on sodium and potassium excretion in rats with chronic renal failure. The chronic renal failure was induced by surgical ablation of 75% renal mass. Controls were shame operated rats. All experiments were performed under sodium pentobarbitone anesthesia. Blood pressure was measured intraarterially and glomerular filtration rate was estimated as inulin clearance. Phentolamine (4 micrograms/kg/min)--Group I; or propranolol (4 micrograms/kg/min)--Group II were infused i.v. to controls and chronic failure rats. alpha-receptor blockade with phentolamine lowered GFR and blood pressure to the same extent in controls and rats with chronic renal failure. alpha-blockade caused increased fractional sodium excretion only in controls while urinary excretion of sodium and potassium fell in rats with chronic renal failure. The beta-blockade with propranolol (4 micrograms/kg/min)--Group II did not affect both blood pressure and GFR either in controls nor in rats with chronic renal failure. However propranolol infusion increased sodium and potassium excretion in controls but not in rats with chronic renal failure. Our study showed the divergence in the role of adrenergic receptors in regulation of urinary electrolytes excretion between controls and rats with chronic renal failure.

Animals↗
PubMed1991

[Subcutaneous administration of recombinant human erythropoietin (R-EPO) in the treatment of anemia in predialysis patients with chronic renal failure].

10 anemic (HB less than 9.0 g/dl) predialysis patients with chronic renal failure were treated for three months with s.c. administration of r-Epo. Blood morphological parameters were estimated using hematological autoanalyser Technicon H1. An increase of the mean hemoglobin (Hb) level from 8.39 to 10.57 g/dl was observed. In 8 patients Hb concentration after 3 months therapy ranged from 9.4 to 12.7 g/dl, but in the remaining two of them Hb was lower than 9.0 g/dl. Appearance of a high percentage of hypochromic erythrocytes is probably the most characteristic response to r-Epo treatment. This phenomenon was caused by iron deficiency. A significant increase of serum creatinine and BUN levels were observed in treated patients, without the concomitant decrease of endogenous creatinine clearance. No clinical symptoms suggesting deterioration of the renal function were observed. Subcutaneous therapy with r-Epo appeared an effective and convenient method of treatment of anemia in predialysis patients.

Adult↗
PubMed1991

[Evaluation of erythropoiesis under the influence of recombinant human erythropoietin (R-EPO) in dialyzed patients].

5 deeply anemic (Hb less than 8 g/dl, Ht less than 25%) dialyzed patients with chronic renal failure were treated during four months with r-Epo. Blood cells morphological parameters were estimated using hematological autoanalyser Technicon H1. Satisfactory increase of the Hb levels and RBC counts were observed in 4 patients, in one the improvement was insignificant. We observed three types of response to r-Epo treatment: 1) macrocytic type, 2) hypochromic type, and 3) non-hypochromic type, without lasting macrocytosis. Our results suggest that type of erythropoiesis depends on other active biological substances (iron, folic acid, vit. B12) necessary for correcting erythropoiesis. r-Epo administration appeared to be a safe and effective method of anaemia treatment in dialyzed patients. Its administration eliminated blood transfusion for six months.

Adult↗