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Biomedical subjects

A Manetti

Publications and source records attributed to A Manetti.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Usefulness of pulsed doppler echocardiography in the diagnosis and medical therapy of patent ductus arteriosus in the newborn with respiratory distress].

In preterm infants patent ductus arteriosus (PDA) may worsen the clinical course of Respiratory Distress Syndrome (RDS). Indomethacin is usually effective in producing duct closure in the first days of life, but clinical diagnosis is often difficult to perform in these patients. In recent years Pulsed Doppler Cross-Sectional Echocardiography (PD-CSE) has made it possible to identify the duct and to assess noninvasively the characteristics of blood flow within it. The aim of this study was to verify the utility of PD-CSE in the early diagnosis of PDA and to provide the basis for a more effective drug therapy. Among 51 patients with RDS, a significant PDA was evidenced in 20 with PD-CSE and in only 8/20 with physical and E-TM examination (p less than 0.01). Indomethacin administration produced duct closure in 19/20 patients (95%). In this study PD-CSE has been more sensitive than the other noninvasive procedures in the diagnosis of PDA; moreover, the success with drug therapy demonstrates the utility of this procedure in providing the basis of a more effective treatment of the duct.

Ductus Arteriosus, Patent↗
PubMed1990

[Familial pulmonary stenosis: considerations on genetic aspects].

A family with 4 cases of pulmonary valvular stenosis with under-developed or normal right ventricle, is reported. The father and his three daughters were affected. In two of the girls, who were twins, a prenatal diagnosis was made using 2D-echo. The importance of genetic counseling and prenatal diagnosis in the families at risk are underlined.

Adult↗
PubMed1990

[Mitral valve prolapse. A prevalence study using bidimensional echocardiography in a young population].

The results of many studies on the prevalence of mitral valve prolapse have been greatly influenced by the diagnostic methods and criteria adopted as well as by population selection. The method of choice today is 2d-echocardiography because of its ability to highlight both movement anomaly (i.e. functional prolapse) and any eventual morphological variations of the mitral valve (i.e. anatomic prolapse). The latter (chordae lengthening, thickening and overabundance of the leaflets, dilation of the valvular ring) are, nowadays, considered especially important even as predictive factors of complications. Therefore we studied the prevalence of these two types of prolapse in a population of 420 university students. Functional mitral valve prolapse was found in 27/420 (6.4%) and anatomical prolapse in 2 cases (0.5%). No auscultatory finding was present in 24/27 patients with functional prolapse. There was no correlation between the two types of mitral valve prolapse and the body mass index, the fractional shortening of the left ventricle and symptoms (dyspnea, palpitations, precordial pain, dizziness). We think that the distinction between the two types of mitral valve prolapse should prove very useful for the comparison of results in future epidemiological studies. Follow-up of both groups of patients will hopefully clarify the usefulness of such distinction from the clinical point of view.

Adult↗
PubMed1989

[Echocardiographic study of heart rhabdomyoma in tuberous sclerosis].

In order to study the prevalence of cardiac rhabdomyoma in tuberous sclerosis using non invasive methods, 11 consecutive patients affected by tuberous sclerosis (age: 3 months-22 years, mean 6 years) were examined between January 1984 and April 1987. In each patient clinical examination, 12 lead electrocardiogram, M-mode and two-dimensional echocardiogram were performed: on 7 of them a 24-hour ambulatory electrocardiogram was also performed. Clinical examination revealed a systolic murmur (grade 3/6) in two cases. In one of them it was associated with cyanosis and cardiac failure. None of other patients showed signs or symptoms related to the heart during clinical examination. ECG was abnormal in 3 cases (ventricular pre-excitation in 2 cases and left ventricular strain in 1). Two-dimensional echocardiogram showed single or multiple intracardiac masses suggestive of cardiac rhabdomyoma in 8 cases; in 3 of them masses were isolated, intramural, and in the interventricular septum, from 5 to 16 mm in diameter; in the other 5 cases they were multiple, intramural and endoluminal, in the interventricular septum, in the right or left ventricle, from 7 to 20 mm in diameter. Ambulatory electrocardiogram revealed only isolated ectopic supraventricular and ventricular beats in 2/7 cases. Each patient was clinically controlled every six months using ECG standard and two-dimensional echocardiogram. The mean follow-up period was 32 months (range 9-53). This study confirms the usefulness of the two-dimensional echocardiography to visualize intramural or intracavitary masses due to cardiac rhabdomyoma in patients with tuberous sclerosis, especially when they appear clinically asymptomatic. Two-dimensional echocardiography is probably the ideal method to use in order to evaluate potential increase in cardiac rhabdomyoma, when prolonged follow-up studies are performed.

Adult↗
PubMed1984

Transient asymmetric ventricular septal hypertrophy in the newborn unassociated with maternal diabetes.

Severe hypertrophy of the interventricular septum was found by echocardiography in a 15 day old infant without symptoms whose mother was not diabetic. The electrocardiogram showed pronounced intraventricular conduction disturbances. Both echocardiographic and electrocardiographic findings showed no abnormality after 27 months, the explanation for which could be the spontaneous regression of an intracardiac rhabdomyoma.

Cardiomyopathies↗
PubMed1983

A-V block by an overdose of Clonidine.

The case of a young addict woman, chronically treated with Clonidine, in whom an overdose of the drug determined transient S-A and A-V conduction disturbances is reported. Such effects have been attributed to vagal hyperactivity and must be kept in mind when the drug is administered to patient of old age, with cardiac disease, or in association with digitalis. The treatment of choice is represented by forced diuresis induced either by osmotic diuretics of furosemide.

Adult↗
PubMed1981

Spontaneous reversion to normal sinus rhythm after prolonged atrial fibrillation.

Two patients are reported in whom there was a spontaneous reversion to normal sinus rhythm after atrial fibrillation had persisted ten and fourteen years respectively. One of these patients was an exception to the general rule in as much as there was a clinical improvement when sinus rhythm appeared again. The mechanism underlying such changes in rhythm is not yet fully understood.

Atrial Fibrillation↗
PubMed1981

Echocardiographic pitfalls in the diagnosis of pulmonary hypertension.

The M-mode echocardiographic pattern of pulmonary arterial hypertension was found in a patient with patent ductus arteriosus and normal pulmonary pressure at catheterization. It is suggested that in this case, as in others reported in the literature, not only pressure but also the pattern of pulmonary blood flow may influence pulmonary valve position in systole and accordingly its echocardiographic representation.

Adult↗
PubMed1981

[Epidemiology of the cardiovascular malformations. II. Follow-up of 337 newborn in 1975-1980 at the Maternity of Florence (author's transl)].

337 newborn, in whom a cardiovascular malformation was diagnosed at birth by criteria previously reported, were followed for variable period of time from January 1975 to December 1980. They came from a population of 32,561 live births which occurred at the Maternity of Florence in the same period. The diagnosis was confirmed by angiography, surgical procedure or autopsy in the 15 per cent of the whole group. Fifty-nine babies (18 per cent) with one exception died within the first year of age. Signs and symptoms referable to the cardiovascular malformation at birth disappeared during the follow-up period in 33.8 per cent of cases. Total incidence lowered from 10.3 per thousand at birth to 6.8 at the end of the follow-up. The percentage of normalized babies correspond to the frequency with which ventricular septal defects close spontaneously in the first period of age and accounts for the disappearance of this malformation from the first place of relative incidence of cardiac malformations in adults.

Child, Preschool↗