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Biomedical subjects

A Majima

Publications and source records attributed to A Majima.

At least 37 records · Page 2Linked to original sources
PubMed1994

[Multicenter prospective study of retinopathy of prematurity--III. Timing of the coagulation therapy and the course of retinopathy of prematurity after coagulation].

We reviewed the records of 360 cases of retinopathy of prematurity (ROP) in 12 institutions in Japan, and investigated the timing of the coagulation therapy and the course of ROP after coagulation. The first coagulation therapy was performed at 9.6 weeks after birth and 35.9 weeks of postconceptional age on the average. The severity index in individual infants also showed that the disease became worse during the period from 32 to 36 weeks of postconceptional age. However, the fundus was clearly visible and there was no primary hazy media during this period. On the basis of the results of the timing of the first treatment, the visibility of the fundus, and the severity index in individual infants, we concluded that an ophthalmological examination with special care should be performed during the period from 32 to 36 weeks of postconceptional age.

Humans↗
PubMed1994

[Multicenter prospective study of retinopathy of prematurity--IV. Comparison with the data from University of Miami].

We investigated the records of 360 cases of retinopathy of prematurity (ROP) in 12 institutions in Japan (we treated the severe progressive "plus" disease by coagulation therapy), and compared them with data from University of Miami (Ophthalmology 94: 620-629, 1987), as representative of the natural course of ROP without coagulation therapy in those days. The timing of the first examination and the first positive diagnosis were later at University of Miami than in Japan. The time of maximal severity of the disease and occurrence of regression were also later the University of Miami than in Japan. In Japan, the first examination was performed at 29 weeks of postconceptional age or at 3 weeks after birth. At the University of Miami, the first examination was performed at 32 weeks of postconceptional age. If the severe progressive "plus" disease is to be properly treated by photo-coagulation or cryotherapy, it is essential to commence fundus examination earlier.

Florida↗
PubMed1993

[Experimental study on local cooling of the eyeball in ocular surgery (4). The local cooling effect on uveal blood circulation, intraocular pressure, and intravitreous pressure].

The effects of local cooling on the uveal blood circulation, intraocular pressure, and intravitreous pressure were evaluated. Saline solutions maintained at 10 degrees C and 35 degrees C were dripped on the rabbit ocular surface. After 5-minute dripping of 10 degrees C saline solution, the temperature decreased by 10.6 degrees C at the ciliary body, 7.7 degrees C at the choroid and 2.9 degrees C at the central region of the vitreous. Hydrogen clearance with electrolytically generated hydrogen gas was employed to measure the tissue blood flow, which fell to 82.9% of normo-thermal value at the ciliary body and 86.3% at the choroid. The intravitreous pressure dropped by 2.8 mmHg. After 30-minute dripping of 10 degrees C saline solution, the intraocular pressure dropped by 3.0 mmHg. We consider that the reduction of intraocular and intravitreous pressure during local cooling of the ocular surface is related to decrease in the uveal blood flow.

Animals↗
PubMed1989

[Studies on the mechanism of closure of the embryonic fissure (II). A morphological study of a transmission electron microscope].

The object of this study was to elucidate the mechanism of closure of the embryonic fissure with a transmission electron microscope in mouse embryos. Every specimen was cut at right angle to the embryonic fissure. Desmosome-like junctions and gap junctions were found between the cells of the inner wall and those of the outer wall of the optic cup. The lip facing the embryonic fissure of the optic cup was covered with the basal lamina. In the section immediately before closure, the cells composing the lip were flattened and had processes on their margins. In addition, collagen fibrils appeared in some portions on the basal lamina. The more posterior section of the same specimen showed immature cell junctions and fusing parts between the cells of both sides. It was deduced that the cells which composed the lip produced the collagen fibrils on the basal lamina when both lips drew closer together. After the adhesion of both basal laminae, immature cell junctions appeared transiently between the cells on either side. The fusion of these cells resulted from disappearance of the cell junctions.

Animals↗
PubMed1989

[The local cooling effect of anterior chamber irrigation on the blood-aqueous barrier].

Local cooling effect on the breakdown of the blood-aqueous barrier (BAB) following anterior chamber irrigation, including additional direct irritation of the iris, was evaluated fluorophotometrically. The rabbit anterior chamber was irrigated with simulated aqueous humor (S-MA 2) the temperature of which was maintained at 35 degrees C or 10 degrees C. The fluorophotometry was performed before and 4, 24, 48 hours and 7 days after irrigation for 30 or 60 minutes. The temperature changes in the anterior chamber, retrolental vitreous body and posterior retina were also measured with a thermocouple during irrigation at 10 degrees C. The temperature of the anterior chamber and the retrolental vitreous fell to 15.0 degrees C and 28.2 degrees C, respectively, within 30 minutes after starting irrigation, whereas the temperature drop in the posterior retina was only 2.0 degrees C after 60 min. At 4 hours after 60-minute irrigation, the breakdown of the BAB was greater than following 30-minute irrigation. There was no significant difference in the BAB breakdown between eyes irrigated at 10 degrees C and 35 degrees C.

Animals↗
PubMed1984

A case of retinitis pigmentosa associated with Coats' syndrome.

The association of bilateral retinitis pigmentosa with Coats' syndrome is reported. Four lesions of vascular telangiectasis with yellowish exudates were treated by xenon photocoagulation or cryocautery. Seven months later, new vascular changes occurred in another quadrant of the fundus. Since xenon photocoagulation could not be performed because of the patient's aversion to pain, argon laser photocoagulation was used but found ineffective. Cryocautery was necessary to treat the exudation over one quadrant, though xenon photocoagulation was effective in small lesions.

Adolescent↗