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Biomedical subjects

A Majewski

Publications and source records attributed to A Majewski.

At least 73 records · Page 4Linked to original sources
PubMed1979

[Breast biopsies which failed to show cancer (author's transl)].

A review is presented on 520 patients who had biopsies of the breast which did not show cancer between 1972-1974. These patients are compared to 304 patients whose biopsies definitely showed cancer of the breast and 520 patients who came to the hospital because of well defined gynaecological disease such as uterine fibroids or uterine prolapse. Comparison of these groups regarding age, past history, indications for the biopsy showed that patients with a biopsy without proof of cancer are difficult to follow for diagnosis. Follow-up on these patients is difficult, however, it is important since up to 4% of these patients with previous negative biopsies later have cancer of the breast. A decrease of biopsies in favor of non-surgical diagnosis of breast lesions can only be recommended under optimal conditions. Under other circumstances the risk of cancer of the breast is high enough to justify a liberal indication for breast biopsies.

Adult↗
PubMed1978

[Estrogen therapy and carcinoma of the endometrium (author's transl)].

The public discussion and the discussion among gynaecologists about the possible increased risk to develop carcinoma of the endometrium following post menopausal treatment with estrogens has lead to insecurity and restricted attitudes in the prescriptions of estrogens. In a statistic comparison of matched pairs of 130 cases of carcinoma of the endometrium with an equal number of selected control cases the following findings were elucidated: 1. Any estrogen preparations do not increase the relative risk for the development of carcinoma of the endometrium. 2. Differentiation into conjugated estrogens, estriol, oral contraceptives and various other estrogen compounds showed a similar trend. 3. Estrogen-androgen compounds and estrodiol compounds did not increase the relative risk for endometrial carcinoma. 4. The relative risk does not increase by prolonged ingestion of estrogen preparations in general and not for conjugated estrogens especially. 5. In the presence of other risk factors such as nulligravity, hypertension, obesity the relative risk for the development of carcinoma of the endometrium is significantly decreased when estrogens were taken, especially when the coincidental risk factor to estrogen ingestion was obesity. The above results suggest that the restraint in the prescription of estrogen for fear of endometrial carcinoma is not justified.

Adult↗
PubMed1977

[Increasing individualization of the treatment of carcinoma of the endometrium (author's transl)].

Metrium seen from 1969 to 1973 are reported. These results were compared to the results of treatment of carcinoma of the endometrium at the same institution between 1944 and 1960. There was a considerable increase of the mean age of the patients. Consequently the operability was reduced to 74.3%. The necessity to resort to primary radiotherapy rose to 25.7%. Diseases of old age were contra-indications to operative treatment. In cases generally fit for operation the contra-indications to vaginal surgery increased. Vaginal hysterectomy was therefore only employed in 78.5% of the operations. An individualization of the treatment of carcinoma of the endometrium is recommended. Continually good or improved results of the treatment are expected by individualization in the group of patients which already showed impaired health by age or concomittant diseases.

Age Factors↗
PubMed1977

[The optimal treatment of carcinoma in situ of the uterine cervix (author's transl)].

The results of treatment of carcinoma in situ of the uterine cervix in 380 patients seen between January 1, 1966 and December 31, 1973 are reported. There were 134 women age 40 or less. There were 246 patients age 40 or older. In 334 patients a total hysterectomy with removal of a vaginal cuff was carried out (87.9%). A large therapeutic cone biopsy was done in 46 patients (12.1%). In the 334 patients treated by hysterectomy, 2 recurrent carcinomas in situ of the vaginal vault were observed (0.6%). In 16 of the cases treated by conization later suspicious colposcopic and/or cytologic findings made hysterectomy necessary. In 5 of these cases a recurrent carcinoma in situ was likely. The postoperative morbidity after total hysterectomy was low. There was no postoperative death. The total vaginal hysterectomy with removal of a vaginal cuff is recommended as treatment for carcinoma in situ of the uterine cervix in order to avoid the diagnostic difficulties in the follow-up after treatment by conization and because of the low recurrence rate after hysterectomy. Conservative treatment should only be employed in patients who desire later child bearing. tthe psychological stresses of the continually required follow-up examinations after conization should not be underestimated.

Adult↗
PubMed1976

Massive cerebellar abscess due to candida albicans.

A case of a previously healthy 51-year-old man, who was diagnosed clinically as having a posterior cranial fossa tumour. At operation this proved to be an abscess which was radically removed. Histological investigations showed the presence of a fungus which was identified as Candida albicans.

Brain Abscess↗
PubMed1976

[Clinical problems of the breast carcinoma in situ].

A report of carcinoma in situ of the breast, including problems of diagnosis and treatment. Over a 6-year period cut of a total of 743 carcinomas of the breast, 77 carcinomas in situ were observed. The difficulties of diagnosis are reviewed. Treatment consisted of simple mastectomy. In view of the inadequate therapeutic results it is recommended that a modified radical mastectomy should also be done in all cases of carcinoma in situ of the breast. The pros and cons of postoperative radiation are discussed.

Adolescent↗
PubMed1976

[The importance of the results of pretreatment pelvic lymphographies in the prognosis of carcinomas of the uterine cervix. A critical evaluation of the proposal to classify these tumors according to the TNM system (author's transl)].

Between 1966 and 1969, 494 patients with carcinoma of the uterine cervix stages I a to IV were admitted in our hospital for primary treatment. In 420 of these patients with carcinoma of the cervix stage I b to IV, complete results of bilateral pretreatment pelvic lymphography are available. The correlation between the results of the lymphographies, the choice of the operative treatment and the cure rates in these 420 cases are reported. All the correlations between the results of the pretreatment lymphography and the prognosis are described. A positive lymphography was in our series of high prognostic value. A plea is therefore made to include the results of the pretreatment lymphography into the classification of carcinoma of the cervix. Classification of the carcinoma of the cervix into the TNM categories is desirable. Our series is reported in these TNM categories. The advantages of such classification are described. The morbid entity of carcinoma of the cervix becomes more transparent to the observer and the choice of operative therapy becomes easier. The prognosis is more clearly established. The proposals of the TNM committee of the UICC for the classification of carcinoma of the cervix according to the TNM categories and the staging according to these categories are discussed critically.

Female↗
PubMed1976

[Evaluation of the results of diminution mammoplasties (author's transl)].

The results of diminution mammoplasties are reported. From 1972 to 1974, 70 diminution mammoplasties according to Strömbeck were carried out. Indication for the operation was hypertrophy of the breasts with side effects of morbid value. In 47 patients side effects of the body posture were the leading indication. In 23 patients, psychosocial problems were the indication. Only patients with side effects of morbid value were considered to be sufficiently motivated to tolerate the total stress of the operation and the possible post-operative complications. The technical problems of the operation and the post-operative complications are described. 43 patients were followed up at least one year after the operation. In 36 patients the pre-operative complaints were alleviated by the operation. In 7 patients there was improvement. No patient had continuing pre-operative complaints. The mentally depressed and physically and psychologically in their relationship to their environment handicapped patients became usually more satisfied by the operation. Diminution mammoplasties are recommended for the operative treatment of hypertrophy of the breast with side effects of morbid value.

Adolescent↗
PubMed1975

[The treatment of carcinoma in situ of the breast (author's transl)].

The management of 63 carcinomas in situ of the breast is reviewed. These 63 carcinomas in situ occurred among 575 carcinomas of the breast from 1969 to 1973. The treatment consisted of simple mastectomy. In cases of early invasion the axilla was explored by palpation of the adipose tissue for enlarged lymph nodes. None were found and no extirpation of the axillary nodes was carried out. Of 59 patients with carcinoma in situ of the breast, 3 later had a local recurrence. Two patients later died of distant metastases. In view of these inadequate results of simple mastectomy it is recommended that a modified radical mastectomy should also be done in all cases of carcinoma in situ of the breast.

Axilla↗