Effect of age on the distribution of drug in blood.
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Biomedical subjects
Publications and source records attributed to A Maeda.
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The content of IgG, IgA, IgM, transferrin, haptoglobin, alpha2 macroglobulin, alpha1 acid glycoprotein, alpha1 antitrypsin, beta1C/1A globulin and beta1E globulin in the sera of 172 female rheumatoid patients and 132 female non-rheumatoid subjects was measured by the single radial immunodiffusion method. Rheumatoid patients were classified into 3 groups according to their stage and class. Canonical discriminant analysis revealed that the alpha1 acid glycoprotein and beta1C/1A globulin was of assistance in differentiating the rheumatoid and non-rheumatoid groups. There is no significant difference in serum protein levels between rheumatoid factor positive and negative groups, whereas IgA and beta1E globulin levels exhibited certain differences between these two groups. Among the results of other clinical tests, the correlation observed between ESR and serum protein levels in rheumatoid arthritis should be mentioned.
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This study was undertaken to investigate the effects of Althesin and surgery on plasma concentrations of luteinizing hormone (LH) and testosterone in 10 male patients. Plasma LH concentrations increased markedly during Althesin anaesthesia given alone over a period of 45 min. The high concentration lasted for 30 min after the start of surgery and was followed by a gradual decrease, although the concentration remained significantly greater than the control value. Plasma testosterone concentrations decreased during Althesin anaesthesia, and a further decrease was noted during the period following surgery.
The effects of althesin on adrenocortical and thyroid function were investigated by measuring plasma concentrations of cortisol, thyroxine (T4) and free thyroxine index (FTI) in 29 surgical patients. Althesin did not change the plasma cortisol concentrations from the preanaesthetic control value; however, the concentrations increased significantly after the start of surgery and thereafter. Althesin anaesthesia per se decreased slightly, but significantly, plasma T4 concentration, but did not influence the FTI value. The surgical operation increased the FTI value slightly but significantly. Our data would suggest that Althesin anaesthesia can be used in patients who have abnormal adrenocortical or thyroid activity.
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During a period from 1971 to 1972, some cases of stillbirth and abortion associated with porcine parvovirus infection were recognized in swine herds in Japan. The brain was examined histopathologically in five stillborn piglets and four dead fetuses from which the parvoviruses had been isolated. Similar histological changes were observed in all the piglets and fetuses, except one piglet which was free from recognizable lesions. The brain lesions were considered to belong to the category of meningoencephalitis consisting of perivascular cuffing of proliferating adventitial cells and a few plasma cells. They were localized in the cerebral gray and white matter and leptomeninges, but not in the cerebellum. These histological lesions were thought to be pathognomonic to porcine parvovirus infection. The difference in brain lesions between porcine parvovirus infection and Japanese encephalitis virus infection was discussed.
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