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Biomedical subjects

A Mackert

Publications and source records attributed to A Mackert.

27 records · Page 2Linked to original sources
PubMed1990

The influence of phototherapy on serotonin and melatonin in non-seasonal depression.

Circadian profiles of melatonin in serum and serotonin in blood were assessed before and after 7 days of artificial light treatment in 30 patients with non-seasonal depression and 12 healthy subjects. Patients and volunteers were allocated at random to either dim (50 lux) or bright light (2,500 lux) for 2 hours daily. The study has not been completed yet. Preliminary findings are presented here. Light treatment modifies marginally the circadian melatonin profiles of depressed patients and healthy subjects; however, it augments blood serotonin throughout the day. This increase is seen in all patients and healthy subjects after bright as well as dim light. These results suggest that the influence of light is more pronounced on serotonin than melatonin metabolism.

Adult↗
PubMed1989

Saccadic reaction times in acute and remitted schizophrenics.

Schizophrenics are known to have various disturbances of the visuomotor system. Whereas smooth pursuit eye movement disorders have been repeatedly confirmed, there are relatively few reports regarding possible disturbances of the saccadic system. In this study, the saccadic reaction times of 47 schizophrenic inpatients were investigated upon admission and later in the remitted state; 28 age- and sex-matched normal volunteers were tested as controls. Psychopathology and outcome were evaluated according to the Brief Psychiatric Rating Scale and the Prognostic Scale. Light stimuli were presented at random direction, location (ranging from 0 degrees to 20 degrees) and duration (800, 1000, and 1200 ms). The eye movements were recorded by electro-oculography. Compared with the control group, schizophrenics revealed prolonged saccadic reaction times, which correlated with pronounced negative symptoms and an unfavourable course of the illness. The saccadic reaction times remained prolonged in schizophrenic patients. These findings suggest attentional deficits in schizophrenics.

Acute Disease↗
PubMed1989

[Saccadic reaction times and visuospatial disorders of attention in schizophrenic patients with negative symptoms].

Schizophrenics display various oculomotor disturbances. In this study we investigated saccadic reaction times in 47 unmedicated schizophrenics (ICD-9) as well as 28 age and sex matched normal controls. Using a cluster analysis according to the BPRS we determined two subgroups each with high and low negative symptoms; we expected poorer results from patients with negative symptoms on account of existing attentional deficits. The eye movements were recorded with electrooculography. Stimuli were presented at random with amplitudes of 5 degrees at a minimum and 20 degrees maximally; the distances between the angles were kept as short as possible, and we chose a fast stimulus rate (800, 1.000 and 1.200 ms). Only the group of schizophrenics with pronounced negative symptoms showed significantly delayed saccadic reaction times, whereas other schizophrenic patients did not differ from the controls. An unfavorable course of the illness also was associated with delayed reaction times. The saccadic reaction times were delayed in both the right and left visual field to the same degree. The poorer performance of the schizophrenics with pronounced negative symptoms are being discussed in relation to attentional deficits regarding visuospatial functions.

Adolescent↗
PubMed1986

Influence of standing on vestibular neuronal activity in awake cats.

Single-unit activity of vestibular nuclear neurons was recorded in chronically prepared, awake cats. To examine the influence of tonic activation of limb proprioception on vestibular function, the vestibular modulation by horizontal rotation (0.2 Hz, 17 deg) and head-tilt (0.1 Hz, 7 deg) was recorded in animals with freely hanging limbs and was compared with the modulation in standing cats. Of 29 examined cells responding to horizontal rotation, only about 30% were affected during standing, with most exhibiting a decrease of the mean discharge rate and gain. In contrast, about 70% of the 28 tilt-modulated cells showed pronounced effects during standing with a decrease of the gain and an increase of the mean discharge rate. The increase of the mean discharge rate in tilt cells may be caused by the excitatory spinovestibular afferent fibers or by the efferent vestibular system. For the observed inhibitory effects on the gain different mechanisms may be responsible: cerebellar inhibition and/or efferent vestibular receptor control. This control of labyrinthine information by somatosensory afferent fibers may serve for the stability of equilibrium in the moving animal.

Animals↗
PubMed1984

Responses to corneal stimulation in vestibulospinal units of nucleus Deiters.

In precollicular decerebrated cats, the response patterns of antidromically identified vestibulospinal Deiters's neurons to stimulation of corneal receptors were investigated. These patterns were compared with the responses of the somatosensory receptors of the neck and limbs as well as with the vestibular input of the horizontal semicircular canals. Of the 162 antidromically driven Deiters's units, 23 were influenced, mainly bilaterally, from corneal receptors. Response latencies evoked by electrical stimulation of the cornea ranged from 6 to 16 ms (mean 12 ms). In 99 Deiters's cells, the influence from the limbs was examined: 51 revealed primarily an ipsilateral modulation from proximal joint receptors. Convergence with joint receptor input was found in 16 of the 18 corneally driven cells tested. Of the 115 cells tested, 15 neurons responded to neck rotation in the horizontal plane. A contribution from the lateral semicircular canals was found in 7 of the 101 examined Deiters's neurons. The connection of corneal receptors with the spinal motor system, via a vestibulospinal pathway, may mediate a nociceptive reflex protecting the eyes and the face.

Afferent Pathways↗
PubMedDate not supplied

Increased blink rates in schizophrenics. Influences of neuroleptics and psychopathology.

During a standardized visuomotor task, eye blinking, a possible parameter of central dopaminergic activity, was studied in 18 previously medicated and eight drug-naive schizophrenic in-patients in the acute state and during remission. Whereas schizophrenics executed the visuomotor task with the same precision as age- and sex-matched normal control subjects did, the mean blink rate was increased in both schizophrenic groups. During neuroleptic treatment, the mean blink rate was reduced only in the group of drug-naive patients, but not in the previously neuroleptic treated schizophrenics. This varying blinking activity is discussed with respect to the development of neuroleptic tolerance and influence of psychopathology.

Adult↗
PubMedDate not supplied

Subthreshold symptoms and vulnerability indicators (e.g., eye tracking dysfunction) in schizophrenia.

Subthreshold symptoms in schizophrenia can be prodromal signs of a psychotic relapse. In people without schizophrenia, similar symptoms may indicate the presence of disorders termed schizophrenia spectrum disorders. Subthreshold schizophrenia-like symptoms may indicate a genetically transmitted higher proneness to schizophrenia. Such a higher liability to develop schizophrenia is ascertained on a symptom level. In genetic studies, asymptomatic members of a pedigree are therefore classified as unaffected although they may possess the genes in question. On a biological level, eye tracking dysfunction has been shown to fulfill certain criteria for a vulnerability indicator and therefore promises to offer more information on genetically transmitted proneness to schizophrenia even in people without psychopathological symptoms. Subthreshold symptoms may warrant treatment. The database for prophylactic treatment in populations at high risk, especially those without symptoms, is currently very small.

Genetic Predisposition to Disease↗