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Biomedical subjects

A Mack

Publications and source records attributed to A Mack.

At least 55 records · Page 3Linked to original sources

Induced motion and oculomotor capture.

Three experiments investigating the basis of induced motion are reported. The proposition that induced motion is based on the visual capture of eye-position information and is therefore a subject-relative, rather than object-relative, motion was explored in the first experiment. Observers made saccades to an invisible auditory stimulus following fixation on a stationary stimulus in which motion was induced. In the remaining two experiments, the question of whether perceived induced motion produces a straight ahead shift was explored. The critical eye movement was directed to apparent straight ahead. Because these saccades partially compensated for the apparent displacement of the induction stimulus, and saccades to the auditory stimulus did not, we conclude that induced motion is not based on oculomotor visual capture. Rather, it is accompanied by a shift in the judged direction of straight ahead, an instance of the straight ahead shift. The results support an object-relative theory of induced motion.

Attention↗

13-cis-retinoic acid in conglobate acne. A follow-up study of 14 trial centers.

A follow-up was done on the patients of the German multicenter study with severe conglobate acne who had been treated with different dosages of 13-cis-retinoic acid. Eighty-seven patients were monitored from 12 to 21 months. Optimal long-term therapeutic effects were obtained with an initial dose of 1.0 mg/kg body weight, for 3 months, followed by another 3-month-treatment period with 0.2 mg/kg body weight. Six months after the termination of therapy 96% of the patients were still in remission and 81% after 12 months. Comparative figures for the administration of doses were 84% as opposed to 47% (0.5----0.2 mg/kg body wt.) and 74% as opposed to 37% (0.2----0.2 mg/kg body wt.), respectively. It is suggested from the present data that a high initial dosage of 13-cis-retinoic acid be chosen in order to obtain optimal long-term therapeutic effects. Transiently elevated lipid levels as well as other tolerable side effects return to normal within 3 months at the latest after discontinuation of treatment.

Acne Vulgaris↗

Is perceived motion a stimulus for smooth pursuit.

Previous investigations have challenged the generality of the claim that perceived motion in an effective stimulus for smooth pursuit eye movements. The experiments extend the scope of these investigations. Three experiments test the hypothesis that perceived motion can serve as the stimulus for pursuit when the eye movement does not generate constraining retinal error information. Observers viewed retinally stabilized displays that elicited the perception that a stationary target was moving or that a moving target was moving faster than it was actually moving. The results failed to confirm the hypothesis. Relevant literature is reviewed. We conclude that perceived movement can act as a stimulus for pursuit only when the "perceptual target" has no retinal counterpart.

Eye Movements↗

Saccadic programming and perceived location.

The retinal location of a saccadic target was made discrepant with its perceived position by means of an induced displacement. If localizing the target required information stored in memory, the eye was directed to the perceived target position. Otherwise, it was directed to its retinal location. These findings do not conform to either a strictly retinotopic or spatiotopic model of oculomotor control. Rather they suggest that the position information used to program saccades may be either perceptual or retinal/spatial depending upon whether the information must be accessed from memory.

Eye Movements↗

The effect of axial tension on the load bearing capacity of traction pins.

Skeletal traction is often used in the conservative treatment of fractures. Although a small diameter traction pin causes less trauma, its use is limited by the strength of the pin and the holding power of the bone. Both theoretical analysis and in vitro experiments were conducted to investigate the bending resistance of traction pins subjected to an applied traction force. The results of this study indicate that thin K-wires could be prevented by applying tension. The possibility of a pin cutting through bone is minimal if the cortical bone structure of the patient is normal. However, further in vivo study is necessary to ascertain whether necrosis might occur due to excessive contact stress between the pin and the bone.

Bone and Bones↗

Smooth pursuit eye movements: is perceived motion necessary?

It has recently been shown that perceived motion, in the absence of any appropriate retinal motion, is a sufficient stimulus to generate smooth pursuit eye motions. This raises the question of whether perceived motion is necessary for pursuit. In three experiments we obtained a negative answer to this question: retinal motion always governed pursuit.

Eye Movements↗

The effect of an injectable progestogen contraceptive on blood coagulation and fibrinolysis.

In 26 women receiving either medroxyprogesterone acetate (Depo-Provera) injections or combined oestrogen-progestogen pills for contraception, tests of coagulation and fibrinolysis were performed before treatment, and after 8, 16 and 24 weeks of therapy. In the medroxyprogesterone group no significant changes were induced in fibrinogen, the vitamin K-dependent factors, or antithrombin III. Plasminogen levels fell during therapy, and were significantly lower than pre-treatment values after 16 and 24 weeks. By contrast, the 13 women receiving oral contraceptives showed raised levels of fibrinogen and plasminogen after 8 weeks of treatment, and of factors VII and X after 24 weeks. These data suggest that medroxyprogesterone acetate injections induce fewer changes in the blood coagulation system than oral contraceptives.

Adult↗

Implant assessment.

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Dental Implantation↗

Blood pressure in women taking oral contraceptives.

A controlled prospective survey of women taking oestrogen-progestogen oral contraceptives showed increases in mean systolic and diastolic blood pressure of 14.2 mm Hg and 8.5 mm Hg respectively after four years. The largest increases in individual cases were 36 mm Hg systolic and 20 mm Hg diastolic. Blood pressure returned to pretreatment levels within three months after oral contraceptives had been stopped. These changes in blood pressure were unrelated to the progestogenic potencies of the preparations being taken.

Adult↗