Biomedical subjects
Publications and source records attributed to A M Zvolinskaia.
The article is based on studies of 16 probands. Among 268 relatives of the proband 64 "progenic" were detected. Variability of the character manifestation, i.e. clinical polymorphism, incomplete penetrance and different expressiveness of the pathological gene, is typical of progeny. Genetic analysis helps recognizing this anomaly by external, slightly noticeable symptoms.
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The article deals with problems of differential diagnosis of acquired and inborn hereditary progenies. The frequency of progenies in aggravated families is 28.2% and in the familes without aggravation it is 10.9% (p less than 0.01). The dominant type of inheritance is determined according to the genealogical tree. Progenies of recessive hereditary nature should be differentiated from the dominant type of "slipping through" generation. From the point of view of prediction, hereditary progenies are more unfavourable than the acquired ones because of frequent relapses, and their treatment should be undertaken at an early stage.