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Biomedical subjects

A M Zemskov

Publications and source records attributed to A M Zemskov.

79 records · Page 5Linked to original sources
PubMedDate not supplied

[Effect of sodium nucleinate on ventricular arrhythmia and blood level of medium molecular weight peptides in an experiment].

The experiments on 18 isolated albino rat hearts have shown that sodium nucleinate exerts a protective action on the occurrence of reperfusion ventricular arrhythmias. Sodium nucleinate was given orally in a daily dose of 50/kg for 2 weeks. The agent reduced the blood concentrations of medium-weight molecular peptides, which may be regarded as the liquidation of a factor predisposing to arrhythmias. Other possible mechanisms responsible for the antiarrhythmic activity of sodium nucleinate, which are adaptable to the immunomodulating and membranoprotective properties of the drug, as well as to its ability to enhance intracellular metabolism are also discussed in the paper.

Adjuvants, Immunologic↗
PubMedDate not supplied

[The therapeutic efficacy of sodium nucleinate and monoribonucleotides based on keratoconjunctival test data].

The possibility of using sodium nucleinate for the treatment of acute dysentery has been confirmed in experiments on guinea pigs with the use of the keratoconjunctival test as an experimental model. The capacity of sodium nucleinate to enhance the antibiotic sensitivity of shigellae isolated from infected eyes to kanamycin, tetracycline and chloramphenicol has been established. The effect produced by individual ribonucleotides contained in sodium nucleinate have been studied and found to be differently directed.

Adjuvants, Immunologic↗
PubMedDate not supplied

[A deficient T-cell count and its elimination during the treatment and prevention of infections].

The results of the study of the parameters of the immune system in persons suffering from frequent infections, bacteriocarriers and persons with nonspecific infections are presented. The study revealed that T-cell deficiency of the 2nd and 3rd degrees could be regarded as the universal marker of decreased immune reactiveness. Sodium nucleinate was found to be capable of stimulating the T-cell element of immunity and antibody formation, which made it possible to achieve a considerable decrease in morbidity rate. Sodium nucleinate was shown to be highly effective in the prophylaxis of acute respiratory viral infections, carrier state and in the sanitation of purulent foci of infection.

Acute Disease↗
PubMedDate not supplied

[Dependence of immunological reactivity on blood groups and microflora in patients with chronic purulent otitis media].

Immunological investigation (1-2 level tests with monoclonal antibodies) of 246 OMPC patients has discovered a relationship between the degree of immunological disorder, blood group and microflora. Patients carrying AII and ABIV, Pseudomonas aeruginosa, Staphylococcus aureus, Proteus were more immunologically compromised. These findings may help in the choice of profile immunocorrector.

Adolescent↗
PubMedDate not supplied

[Methods for assessing the efficacy of immunocorrection].

The use immunocorrective remedies has become a topical problem due to the insufficient effectiveness of the treatment of many chronic diseases (including chronic purulent otitis), manifested by the suppression of initial immunological disturbances. Still the principles of the prescription of the above-mentioned remedies have not yet been sufficiently worked out. The present work deals with the use and approval of the methods for the evaluation of the effectiveness of immunocorrective therapy, the determination of the targets of action, the proper effect of modulation, changes in the degree of its manifestation.

Adjuvants, Immunologic↗