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Biomedical subjects

A M Worm

Publications and source records attributed to A M Worm.

At least 73 records · Page 4Linked to original sources
PubMed1985

Erythromycin against Chlamydia trachomatis infections. A double blind study comparing 4- and 7-day treatment in men and women.

In a double-blind controlled study the treatment of erythromycin 500 mg twice daily for seven days was compared with erythromycin 500 mg twice daily for four days in 73 men and women with uncomplicated genito-urinary chlamydia trachomatis infections. At the start of the treatment, 34 of 42 men (81%) and 15 of 31 women (48%) had symptoms suggesting the presence of chlamydial infections. There was a significantly higher bacteriological cure rate with the seven-days treatment in both men and women compared with the four days treatment at the second control visit two weeks after the start of the treatment (p less than 0.0005). The bacteriological cure rate of the women was higher than that of the men, but the results for men and women did not differ significantly. It is concluded that a four day treatment with erythromycin 500 mg twice daily can not be recommended, whereas 500 mg twice daily for seven days was shown to be effective, especially in women.

Chlamydia Infections↗
PubMed1984

Activation of complement in the skin after PUVA therapy.

Suction blister fluid from the abdominal skin of 14 healthy subjects was examined for the presence of split products of complement C3 (C3-split) as an indicator of complement activation before and after treatment with either UVA or PUVA. Following PUVA a significant increase in C3-split was found (p less than 0.05) in both irradiated and non-irradiated skin areas. Following UVA the increase in C3-split was less pronounced. The activation of complement may play an important role in the maintenance of the delayed erythema that appears after irradiation with long-wave ultraviolet light.

Adult↗
PubMed1984

Postinflammatory oedema in two patients with contact dermatitis. Effect of benzo-pyrones.

Two female patients with oedema of the arms and legs due to contact dermatitis complicated with recurrent infections were examined. The concentrations of plasma proteins of different molecular weight in the oedema fluid (collected from suction blisters) were highly increased. Albumin outflux as measured with radiolabelled albumin from the vessels of oedematous skin was markedly decreased corresponding to a decreased lymphatic function. Treatment with benzo-pyrones for 6 months did reduce the protein concentrations of the oedema fluid, but the clinical response was disappointing.

Albumins↗
PubMed1983

Lymphatic albumin clearance from psoriatic skin.

In nine patients with untreated psoriasis vulgaris, human serum albumin labelled with 125I or 131I was injected intradermally in symmetrically located involved and uninvolved skin. The activity of the depots was followed by external detection, and the arrival of labelled albumin in plasma was monitored. In involved psoriatic skin the local mean half-time (T1/2) for tracer disappearance was 20.8 +/- 8.2 (S.D.) hr and in clinically normal skin, 29.1 +/- 9.6 (S.D.) hr. The difference was significant (p less than 0.002). Accordingly, the tracer from involved skin reached higher plasma levels than the tracer from uninvolved skin. However, under slight lymphatic stasis the appearance rate of radiolabelled albumin in plasma from both tissues was minimal during 1 to 2 hours after the injection, indicating that a local direct transvascular drainage of plasma albumin from the interstitium of diseased and normal skin was negligible. We conclude that the previously demonstrated increased extravasation of plasma proteins in involved psoriatic skin is compensated by an increased lymphatic drainage of plasma proteins, and not by an increased local transvascular return.

Adult↗
PubMed1982

Microvascular leakage of plasma proteins after PUVA and UVA.

The transcapillary escape rate of albumin (TERalb), i.e., the fraction of intravascular albumin mass passing to the extravascular space per unit time, is a parameter of the leakage of macromolecules from the total microvasculature. In patients with psoriasis short-term PUVA treatment induces an increase in TERalb. In this study TERalb was measured in 3 groups of normal humans treated with PUVA, UVA and 8-methoxypsoralen. Treatment with PUVA and UVA caused a statistically significant increase in TERalb, whereas treatment with 8-methoxypsoralen did not induce any measurable changes. It is concluded that the UVA irradiation causes the abnormal leakage of macromolecules, whereas psoralen is not the responsible component. Furthermore the phenomenon can be elicited in normals and is not based on a preexisting psoriasis.

Adult↗
PubMed1982

Direct and indirect effects of UVA on skin vessel leakiness.

By using the suction blister technique we have investigated the leakiness of skin vessels in healthy volunteers after whole-body suberythemogenic doses of UVA radiation (a quadrant on one side of the abdominal skin was shielded with lead-rubber). The accumulation of intravenously injected labeled albumin in blister fluid was slightly elevated 1 day after irradiation and increased significantly 2 days later. The blister concentrations of 4 endogenous plasma proteins (albumin, transferrin, IgG, and alpha 2-macroglobulin) were elevated 1 day after radiation exposure and normalized 2 days later. All changes were equal on irradiated and nonirradiated skin. It is concluded that UVA radiation can induce a continued or biphasic increased leakage of plasma proteins in the skin vessels, due to a humoral rather than to a direct physical effect of the radiation on the vessel walls. It is suggested that an increased microvascular leakiness in organs other than the skin might be present.

Adult↗
PubMed1982

Capillary microscopy of the nail fold in patients with psoriasis and psoriatic arthritis.

The Capillary characteristics of the nail fold area were examined and compared by capillary microscopy in 31 patients with psoriasis (PS) and 34 patients with psoriatic arthritis (PA). 70 healthy persons served as controls. Significantly shorter mean capillary loop lengths and characteristic morphological capillary changes were found both in patients with PS and in patients with PA as compared to the controls. The number of hemorrhages and sluggishness of blood flow was more pronounced in both groups of patients as compared to the control group, but only significantly so in patients with PA. The only significant difference between the PS and the PA groups was a higher subpapillary plexus visibility (SPV) index in the latter. It is concluded that most of the capillary changes demonstrable in patients with PA are clinical manifestations of PS. The difference in the SPV index, however, warrants a follow-up study to elucidate whether patients with PS and a high SPV index are likely to develop arthritis.

Arthritis↗