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Biomedical subjects

A M White

Publications and source records attributed to A M White.

84 records · Page 5Linked to original sources
PubMed1968

The effects of catabolic and anabolic steroids on amino acid incorporation by skeletal-muscle ribosomes.

1. A method is described for the routine isolation of ribosomes from small quantities of skeletal muscle that have been homogenized with the Ultra-Turrax tissue disintegrator. 2. Ribosomes prepared by this method from rats receiving triamcinolone acetonide or rabbits receiving cortisone acetate show a marked fall in their ability to incorporate amino acids when compared with ribosomes from control animals. 3. This fall in activity can be partially prevented in rats by pretreating the animals with an anabolic steroid, steroid 36644-Ba. 4. Testosterone (5mg./kg.) administered to rabbits in conjunction with cortisone acetate is not effective in maintaining ribosomal activity. However, steroid 36644-Ba at one-tenth of an equiandrogenic dose (0.05mg./kg.) is extremely effective. 5. The results with ribosomes isolated from rabbits support the concept that steroid 36644-Ba and possibly all anabolic steroids have an ability to counteract the catabolic action of corticosteroids that is greater than their androgenic activity would suggest.

Amino Acids↗
PubMedDate not supplied

Clinical applications of research on fatigue in children with cancer.

Fatigue is a prevalent problem in the pediatric oncology population but is probably under-recognized and undertreated. The research on fatigue in children with cancer presented in this issue offers a welcome exploration of the subject. Clinical nurses must begin to understand the causes and symptoms of fatigue, as well as supportive care measures for their patients. Fatigue can occur in children who receive chemotherapy, radiotherapy, and biotherapy, and in children who are treated with bone marrow transplantation. Education of the patient and family regarding the potential for fatigue is helpful in preparing them for the cancer experience. Factors that contribute to and alleviate fatigue can be identified for each patient, taking into consideration age, developmental level, and cultural background. Parents and patients, especially adolescent patients, may have differing opinions about what fatigue is and what may be helpful. Further research into fatigue in children with cancer is encouraged, especially in patients suffering from alterations in sleep or nutritional status, and in long-term survivors of childhood cancer.

Child↗