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Biomedical subjects

A M Utevskiĭ

Publications and source records attributed to A M Utevskiĭ.

11 recordsLinked to original sources
PubMedDate not supplied

[Uptake of 125I-triiodothyronine by the thyroid gland: effect of adrenergic agents and low temperatures].

A study was made of the binding of 125I-triiodothyronine with the sections, nuclei and mitochondria of the euthyroid thyroid under the conditions of adding adrenergic agents, cooling to 0 degree C and freezing to--196 degrees C. It was noted that 125I-T3 got no less with adding unlabeled T3 and thyroxine that might suggest the unsaturated nature of the process. Among the studied adrenergic agents (noradrenaline, neoepinephrine, propranolol, pyrroxane in the concentration of 1 X 10(-4) M) noradrenaline only influenced this process. It stimulated binding and pyrroxane inhibited it. 125I-T3 binding got less at 0 degree C, after freezing to--196 degrees C the preservation of the basal activity of the process and disappearance of the noradrenaline stimulating effect were noted. The results obtained do not confirm assumptions as to the mechanism of thyroid autoregulation function with T3 by the short feedback type.

Cold Temperature↗
PubMedDate not supplied

[Triiodothyronine binding and norepinephrine uptake in the heart and liver].

Administration of norepinephrine to thyroidectomized rats activates sharply the [125I]triiodothyronine binding by heart mitochondria and liver nuclei. Epinephrine stimulates the binding by the heart mitochondria and decreases the intensity of this process in the liver and heart nuclei and liver mitochondria As compared to norepinephrine, adrenoxyl is weaker in activation of [125I] triiodothyronine binding by the heart mitochondria and stronger in intensification of binding by the liver nuclei. Physiological concentrations of thyroxine like adrenoxyl administered to intact animals 2h before investigations intensify the uptake of [3H] norepinephrine by sections of the auricles, myocardium and liver. Hyperthyroidization induces contrary changes inthe uptake of [3H] norepinephrine. Norepinephrine administration decreases sharply the uptake of [3H] norepinephrine by sections of the auricles and myocardium. The blocking of beta-adrenoreceptors weakens the uptake.

Animals↗
PubMedDate not supplied

[Autoimplantation of cryopreserved (- 196 degrees C) thyroid gland parenchyma as a treatment method in postoperative hypothyroidism].

To treat postoperative hypothyrosis, use was made of implantation of autologous thyroid tissue preserved and stored for 4 to 12 months before patients developed hypothyrosis. It was established that the treatment was followed by an increase in 131I accumulation in the body at the expense of its accumulation by the implant and stimulation of the process in the stump. This was paralleled by a considerable rise in T3 and T4 and reduction in TTH in the patients' blood. The patients substantially improved while the manifestations of hypothyrosis disappeared. The effects detected could be seen throughout the whole observation period (up to 18 months). The patients did not require any additional drug treatment. The data provided attest to the efficacy of autoimplantation of cryopreserved thyroid parenchyma for the treatment of postoperative hypothyrosis.

Follow-Up Studies↗
PubMedDate not supplied

[Effect of cooling on tissue capacity for catecholamine trapping].

The paper deals with capacity of tissues of the bull and rat auricle and of the rat deferent duct for trapping L-[3H] noradrenaline and [3H] adrenaline under different conditions of cooling. It is established that at the preliminary incubation temperature of 20 degrees C the intensity of tissues trapping both the hormone and mediator is essentially decreased and [3H] noradrenaline does not inhibit the adrenaline trapping. When the bull auricle tissue is cooled down to 4 and 0 degrees C its capacity for the [3H]-noradrenaline trapping is restored. The rat deferent duct tissue recover its capacity to the [3H] adrenaline trapping after cooling down to 0 degrees C. Freezing down to -20 and 196 degrees C has a pronounced inhibitory effect on the [3H] adrenaline and [3H] noradrenaline trapping by all the tissues under study. Possible thermodependence mechanisms of the adrenergic mediator-hormones trapping are explained.

Animals↗