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Biomedical subjects

A M Thomas

Publications and source records attributed to A M Thomas.

At least 73 records · Page 4Linked to original sources
PubMed1988

Retained surgical swab debris in post-laminectomy arachnoiditis and peridural fibrosis.

We examined soft tissue biopsies from 26 patients with symptomatic nerve root fibrosis and arachnoiditis after a previous laminectomy. Dense fibrous connective tissue was found about the nerve roots and in 14 cases (55%) fibrillar foreign material was seen within it. This material had the histochemical characteristics of cotton fibres from swabs and neurosurgical patties. In two other cases nerve root fibrosis was associated with residual radiopaque lipid thought to derive from earlier myelography. Our findings suggest that risks may be associated with the introduction of foreign material into the vertebral canal, and that microscopic fragments of surgical swabs and patties may have a role in the pathogenesis of postoperative periradicular fibrosis.

Adult↗
PubMed1987

The missing balloon sign.

The balloon of the self-retaining Foley catheter should be readily visible during ultrasound scanning of the distended urinary bladder. Its absence should prompt a search for its location since extra-vesical inflation may result in local trauma and confusing appearances.

Aged↗
PubMed1987

The microsurgical treatment of lumbar disc protrusion. Follow-up of 60 cases.

The technique and results of microsurgical techniques for lumbar disc protrusions in 60 patients are presented. All patients were followed up for a minimum of 2.5 years, and 91% had good or excellent results. The only patient with a recurrent disc sequestration had a good result after a second operation.

Follow-Up Studies↗
PubMed1986

Imaging of metastatic medullary carcinoma of the thyroid with 131I-meta-iodobenzyl guanidine.

The uptake of 131I-MIBG by medullary carcinoma of the thyroid was studied in six patients after total thyroidectomy in whom persistent raised plasma calcitonin levels were indicative of residual disease. The only patient in whom any activity in a possible metastasis was seen had by far the highest level of circulating calcitonin of the group and in contrast one patient with a presumptive metastatic deposit showed no uptake of MIBG into it. In conclusion the uptake of 131I-MIBG by medullary carcinoma of the thyroid is unreliable and unpredictable.

3-Iodobenzylguanidine↗
PubMed1986

Radiological manifestations of parasitic disease.

Parasitic diseases are very common on a worldwide basis. In certain cases radiological features are of importance both for primary diagnosis and for detection of complications of infestation. This review concentrates on parasitic diseases of radiological interest.

Bone and Bones↗
PubMed1986

Incompetent perforating vein ligation in the treatment of venous ulceration.

Eighty eight incompetent perforating vein (IPV) ligations were performed in 64 patients who were followed up for a minimum of two years, mean 4.4 years. The long term results were good in 85% of cases. It is suggested that IPV ligation is the optimum treatment for venous ulceration and lipodermatosclerosis in patients who have only calf vein damage and that in most cases preoperative ascending venography is not necessary.

Adolescent↗
PubMed1985

Serum C-reactive protein response to therapeutic embolisation: possible role in management.

In a prospective study over 12 months, serum C-reactive protein concentration was measured serially in 20 consecutive patients who underwent therapeutic embolisation for various forms of malignancy and in 13 patients who had diagnostic coeliac or hepatic angiography without embolisation. All the patients who underwent successful embolisation showed a C-reactive protein response and in all cases the height of the response correlated well with the estimated size of the embolised tumour. Patients who recovered uneventfully showed a prompt fall in C-reactive protein from its peak values towards normal. In contrast, patients undergoing angiography alone showed only a minor increase in C-reactive protein concentration unless there were intercurrent complications. These results, together with the commercial availability of rapid and precise assays for C-reactive protein, indicate that serial measurement may be useful in the confirmation of tissue necrosis and assessment of its extent; also in the recognition of intercurrent complications following therapeutic embolisation.

C-Reactive Protein↗
PubMed1985

Preparation of biologically active ristocetin derivatives: replacements of the 1'-amino group.

A series of ristocetin analogues with modifications (OH, C=O, C=NOH, NCOCH3) at the C-1' amino group was synthesized and found to possess antibacterial activity against gram-positive bacteria and to bind to Ac2-Lys-D-Ala-D-Ala, a model for the antibiotic's site of action. Due to the lack of a positively charged amino group, the active analogues could not form a salt bridge, indicating that an electrostatic interaction between the positively charged 1'-amino group of ristocetin and the carboxylate anion of the peptide is not required for complex formation. The only compound that did not exhibit good antibacterial activity was epiristocetin aglycone (an analogue with the 1'amino group in the opposite configuration (S) as ristocetin). On the basis of NMR studies of epiristocetin aglycone in solution, the 1'-amino group is located in the proposed carboxylate binding pocket and may sterically block complex formation.

Chemical Phenomena↗
PubMed1984

Visibility of the renal fascia at intravenous urography.

Contrary to the accepted understanding that visibility of the perirenal fascia at urography is a rare finding and when seen is usually associated with renal pathology, a recent report has suggested that it is a fairly common, normal finding. In a retrospective study, 261 unselected intravenous urograms performed over a 3-month period were analysed. The findings indicate a low incidence of perirenal fascia visualisation and, when present, an association with renal pathology.

Adult↗
PubMed1984

Simultaneous presentation of two cerebral arterial aneurysms.

A case of subarachnoid haemorrhage due to rupture of a middle cerebral artery aneurysm followed by immediate enlargement of a carotid intra-cavernous aneurysm is described. The enlargement of the second aneurysm was due to a rise in blood pressure caused by the subarachnoid haemorrhage. Although multiple aneurysms are common, this phenomenon is very rare and the reasons for this are discussed.

Adult↗