Concurrent peroral administration of dimethylamine (DMA) and sodium nitrite to rats produced necrosis of liver parenchyma and increased the activity of glutamicoalanine transaminase. Similar changes were recorded after administering dimethylnitrosamine (DMNA) that points to potential synthesis of this carcinogen from the precursors. Prolonged (over 2.5 years) feeding with DMA and nitrite resulted in part of the rats in tumours of the lungs and in other neoplasms. Ascorbic acid that blocks the endogenous synthesis of DMNA interfered with the development of tumour and pretumour lesions that emerged as a result of concurrent feeding with DMA and nitrite.

Animal Feed↗

PubMedDate not supplied

[Prostatic sclerosis].

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Adolescent↗

PubMedDate not supplied

[Fibronectin and its significance in pyelonephritis].

Fibronectin levels were measured by enzyme immunoassay in 68 patients with pyelonephritis and 10 patients with chronic cystitis. The patients with chronic cystitis, acute and chronic non-obstructive pyelonephritis exhibited significantly high average blood fibronectin levels, whereas those with chronic obstructive pyelonephritis displayed the levels slightly different from those observed in healthy individuals. Hypofibronectinemia was detected in 23.3% of patients with chronic pyelonephritis. Preincubation of the neutrophils isolated from pyelonephritis patients with fibronectin increased the initially low phagocytic capacity without enhancing their metabolic activity. In experimental pyelonephritis, administration of exogenous fibronectin was demonstrated to contribute to a rapid bacterial elimination from the kidneys, to decrease the intensity of an inflammatory response, to prevent renal histostructural lesions, to enhance the functional activity of immunocompetent cells and to stabilize their membranes. The findings may serve the basis for using fibronectin in clinical practice as a promising agent to treat pyelonephritis.

Acute Disease↗

PubMedDate not supplied

[The morphological characteristics of the nephrotic form of glomerulonephritis in children at puberty].

67 children (from 3 to 18 years of age) and 26 adults (19-30-year-olds) with nephrotic or mixed forms of glomerulonephritis (GN) are studied. The most severe and pleiomorphic forms of GN are found in children of 12 to 15 years of age: mesangio-capillary, mesangial proliferative, extracapillary proliferative GN with "half-moon" structures, sclerosing GN. Pronounced disturbances of the vimentine content and distribution in the basal lamina, of i.v. type collagen, fibronectin in combination with its damage under the influence of various immune deposits (particularly subepithelial ones) are found in these patients.

Adolescent↗

PubMedDate not supplied

[Various immunohistochemical markers of precancer and variants of prostate cancer].

The prostates of 45 patients with benign hyperplasia, precancer and carcinoma of the prostate were studied using histochemical and immunohistochemical methods. The correlation between the expression of the prostatic specific antigen and prostatic acid phosphatase according to the histological type of tumor and the level of differentiation of the prostatic intraepithelial neoplasia (PIN) was established. PIN is connected with acinar glandular epithelium. It occupies an intermediate position between well differentiated non-invasive carcinoma and large-acinar carcinoma. Cytospecificity of these antigens may be used as markers of premalignant lesions for differential diagnosis of precancerous processes in the prostate. Immunohistochemical properties of PIN may be used for revealing groups of a high risk.

Acid Phosphatase↗

PubMedDate not supplied

[Apoptosis and cancer].

Apoptosis is a form of cell death in which the cell actively participates by providing molecules that are directly or indirectly involved in the process and by providing energy for the process to proceed. Apoptosis is a fundamental process which is controlled at the genetic and molecular levels, and as such can be analyzed, understood and manipulated. Cell death in which there is a chromatin condensation prior to damage of cytoplasmic organelles and to disruption of the cell membrane is apoptotic. Apoptosis plays an important role in the regulation of tissue growth, the inhibition of transformation in normal cell and in the control of cancer. A failure of blockade of the apoptotic mechanism is a prerequisite for cancer. Currently, it may not be practical to treat patients with antisense oligonucleotides that target antiapoptosis genes, although such treatments may become available in the future.

Apoptosis↗

PubMedDate not supplied

[Ultrastructural changes in the hemato-testicular barrier in the pathogenesis of infertility].

An ejaculate and biopsy specimen of the testes from 162 patients with infertility of different etiology were studied. General regularities were established of development of pathospermy on the ultrastructural level in diseases of urogenital genesis. Development of infertility appear to be conditioned by consecutive interrelated processes of changes in the structure of different components of the hemato-testicular barrier. Changes in the capillary structure and primary with respect to disorders in other elements of the hemato-testicular barrier. Changes in the germinal system appear to occur secondary to the trophic abnormalities. In the hemomicrocirculatory bed of the testes, structural changes were at their greatest in the venular link.

Biopsy↗

PubMedDate not supplied

[Comparative evaluation of variants of anesthesia in patients with euthyroid goiter].

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Adult↗

PubMedDate not supplied

[The prognostic importance of the immunohistochemical study of protein p53 in transitional-cell bladder tumors].

In an immunohistochemical investigation designed to study a mutated p53 protein in transitional-cell tumours (n = 44) we succeeded in identifying the presence of two types of transitional-cell tumours of human urinary bladder, such as p53 immunopositive and p53 immunonegative transitional-cell tumours. Thus, the results of the immunohistochemical investigation into the protein p53 were found out to directly correlate with the clinical course of transitional-cell tumours, that are held to be of great differential-diagnostic and prognostic significance.

Carcinoma, Transitional Cell↗