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Biomedical subjects

A M Olsson

Publications and source records attributed to A M Olsson.

At least 37 records · Page 2Linked to original sources
PubMed1990

Prognostic factors in clinical stage I nonseminomatous germ cell tumors of the testis: multivariate analysis of a prospective multicenter study. Swedish-Norwegian Testicular Cancer Group.

Between 1981 and 1986, 279 consecutive patients with clinical stage I (CS1) nonseminomatous germ cell tumors (NSGCT) of the testis underwent pathological staging (PS) with retroperitoneal lymphadenectomy (RPLND). Patients with retroperitoneal metastases (PS2) received adjuvant chemotherapy. The median follow-up time after RPLND was 50 months (range, 30 to 90). Clinical and histopathologic features were registered prospectively and analyzed for association with risk of having PS2, relapse despite pathological stage 1 (PS1) or the combined risk of either event, metastatic disease (MET). Seventy-five (26.9%) of the patients had PS2 disease, and 30 (14.7%) of the 204 PS1 patients relapsed, indicating that at least 105 (37.6%) of this CS1 population had subclinical MET at the time of orchiectomy. Four (1.4%) of the 279 CS1 patients died of testicular cancer. Multivariate analyses showed several variables to be significantly associated with outcome for the CS1 patients; vascular invasion in primary tumor and normal preorchiectomy serum alpha-fetoprotein (Pre-AFP) level indicated PS2 disease. If Pre-AFP was excluded from the model, the absence of teratoma or yolk sac elements in the primary tumor became significant predictors of PS2. Vascular invasion, absence of teratoma, and a short interval between orchiectomy and RPLND indicated increased risk of relapse in PS1 patients. Vascular invasion, normal Pre-AFP, absence of teratoma elements, and a short orchiectomy to RPLND interval were predictive of MET. Our results indicate that prognostic factors useful for stratification of CS1 patients with NSGCT to different treatment options may be established.

Chorionic Gonadotropin↗
PubMed1990

One hundred impotent men.

One hundred men complaining of poor or absent erectile capacity were investigated with a multidisciplinary approach. Their median age was 47 years. Mainly organic causes of the erectile failure were found in 27 and mainly psychologic in 40 cases, while factors of both types contributed in 33 cases. Vascular disorder was present in 20 men, including (functional) vasoconstriction in eight. Among 24 men with serum testosterone below 15 nmol/l the incidence of arterial disease, alcoholism and partner-related problems was significantly higher than in those with higher testosterone levels. Most psychologic factors were in general intrapsychic (affecting only the patient himself), while a minority were dyadic (related to the partner).

Erectile Dysfunction↗
PubMed1989

Severe arterial insufficiency in impotence confirmed with an improved angiographic technique: the impact of smoking and some other etiologic factors.

Arteriography of the penile arteries in patients with pharmacologic erection has been performed by our group since 1983. Pathological Doppler findings and weak response to locally administered papaverine or alpha-blocking agents in these impotent men led to pharmacoangiography in 17 of 372 patients with erectile dysfunction; of these 372 patients 130 (35%) had subnormal penile blood flow according to Doppler ultrasonography. Only one had a proximal lesion (occlusion of the right common iliac artery) while the rest had distal lesions. Three patients were nonsmokers and the remaining 14 patients (82%) were smokers or had smoked previously. Only 2 of the 14 had other predisposing diseases.

Aged↗
PubMed1989

Etiologic aspects of impotence in diabetes.

An investigation of 37 diabetics with impotence (15) or erectile difficulties (22) is presented. On average two significant abnormalities per patient were found. Ranked in order of incidence, the causes were as follows: 1) Combination of neuropathy and psychosocial factors, 2) combination of neuropathy and vascular disease, 3) peripheral neuropathy only, 4) combination of hormonal imbalance and psychosocial factors, 5) combination of three or more defects, and 6) penile vascular disease or psychosocial problems only, or hormonal imbalance combined with peripheral neuropathy.

Diabetic Angiopathies↗
PubMed1988

Pharmacoangiography of the penile arteries.

Angiography may play an important role in the evaluation of patients with erectile failure and in whom abnormal Doppler studies indicate arterial insuffiency. The angiographic examination should give information about major pelvic arteries as well as the peripheral branches of the internal pudendal artery. We describe a method for performing pharmacoangiography of the penile arteries, which involves the local injection of a vasodilator into the corpus cavernosum. Angiography during pharmacologic erection provides optimal visualization of the penile arteries and helps to differentiate functional from organic vascular disorders.

Angiography↗
PubMed1988

Pharmacoangiographic assessment of penile arteries in patients with erectile failure.

Pudendal angiography was done before and thirty minutes after intracavernous administration of 6 mg phenoxybenzamine in 8 men in whom screening with ultrasound Doppler had revealed abnormalities of the penile blood flow. Five vessels were not visualized until phenoxybenzamine was given. Four vessels displayed marked dilatation, three had moderate and one had slight dilatation after the pharmacologic erection was provoked. The method appears to be of value to increase the quality of the angiographic examination.

Angiography↗
PubMed1987

Intravenous indomethacin and oxycone-papaverine in the treatment of acute renal colic. A double-blind study.

In a prospective double-blind, cross-over study, 61 patients with acute renal colic were treated with either indomethacin (50 mg) or oxycone-papaverine (5 mg + 50 mg) administered intravenously. For those patients requiring a second injection the drugs were reversed. The intensity of pain was evaluated before and 20 min after each injection according to an analogue visual scale 0 to 100. Both drug regimens provided comparable and significant pain relief; a pain score of less than 20 appeared to be satisfactory and was achieved in almost all cases.

Acute Disease↗
PubMed1986

Accuracy of radiological staging procedures in non-seminomatous testis cancer compared with findings from surgical exploration and histopathological studies of extirpated tissue.

Preliminary and reviewed statements describing results from abdominal CT and US were compared with surgical findings and with the report from the histopathological investigation of extirpated retroperitoneal tissue. No false positive diagnoses of retroperitoneal metastases were made by CT investigation, while US made one false positive but revealed metastases in one patient overlooked by CT. The overall accuracies (correct answers/all patients) were 81% with CT and 80% with US (31 and 21 patients in Group I respectively). Surgical exploration alone was no more sensitive than either of the two other methods. CT and US are highly reliable when positive but the risks of obtaining false negative results are considerable.

Adult↗
PubMed1984

Malignant lymphoma of the testis.

Lymphoma presenting in the testis was evaluated in 24 patients. The tumours were classified according to both the Rappaport and the Kiel classification. The Rappaport classification yielded only two tumour types--15 diffuse histiocytic and 9 diffuse mixed histiocytic-lymphocytic, with no pure lymphocytic lymphoma. No difference in survival time was found between these two tumour types. According to the Kiel classification there were four histological tumour types--immunoblastic (11 cases), centroblastic (2), centroblastic/centrocytic (6) and polymorphic immunocytic (5). In comparison with the other tumour types, the centroblastic/centrocytic lymphomas seemed to be advantageous as regards survival. It is concluded that systemic treatment with chemotherapy in accordance with current principles for malignant lymphoma is indicated following orchiectomy in localised testicular lymphoma as well as in disseminated disease. The value of post-operative radiotherapy to regional nodes is questionable.

Adult↗
PubMed1984

Testicular tumour markers in tissue correlated to serum levels and clinical stage.

Clinical investigation of 11 patients with testicular tumour included tests for the marker substances AFP (alpha fetoprotein) and HCG (human chorionic gonadotropin) in serum and in tumour tissue, using an indirect immunoperoxidase technique. In one case of pure seminoma, neither AFP nor HCG was detectable in tissue or in serum. In eight of ten patients with non-seminomatous germ cell tumour there was AFP-immunoreactivity in tumour tissue, and seven of them also had elevated serum levels of AFP. Five patients showed HCG-immunoreactivity in tumour tissue and the same number had elevated serum levels of HCG. The findings indicated good correlation between immunoreactivity of tumour tissue, serum level of the tumour markers and clinical stage of the neoplastic disease.

Chorionic Gonadotropin↗
PubMed1983

Examination of the pathological scrotum with dynamic and static ultrasound.

Ultrasound examination was performed on 51 patients with clinically pathological scrotum who all underwent surgery. Twenty patients had extratesticular disease and 31 patients had intratesticular disease. The disease was located correctly by ultrasound in all cases. It was, however, not possible to tell a malignant from a benign lesion, or a teratoma from a seminoma. A combination of contact scanning with direct palpation of the lesion and scanning through a water bath or similar "stand-off' arrangement is recommended.

Adolescent↗
PubMed1982

Erectile function before and after aorto-iliac reconstruction: a comparison between measurements of Doppler acceleration ratio, blood pressure and angiography.

The penile circulation was assessed in 20 males submitted to aorto-iliac reconstructive surgery by preoperative angiography and Doppler measurement of penile acceleration ratio (PAR) and penile blood pressure pre- and postoperatively. Ten patients had erectile dysfunction preoperatively. Four of them regained erections after operation and a 5th patient got values indicating the same. One patient lost his erectile capacity due to resection of a wide collateral whereas another had his erections impaired but not lost by the operation. As a diagnostic tool the PAR method was better than the systolic penile blood pressure which was prone to under-diagnosis. We recommend the registration of both in patients with erectile dysfunction or occlusive arterial disease.

Adult↗
PubMed1981

Palliative embolization of renal tumors: follow-up of 19 cases.

Palliative renal artery embolization (without subsequent nephrectomy) was performed in 19 patients with renal carcinoma, and the follow-up is presented. Seventeen of the patients had metastatic disease at the time of embolization. Three patients were alive 11, 52, and 56 months after embolization. Gross hematuria was eliminated in 5 patients. Temporary remission of suspected pulmonary metastases was seen in 2 patients. It is concluded that transcatheter embolization alone is not curable and in this series did not affect the overall survival rate; however, local tumor symptoms may be palliated by this method.

Adenocarcinoma↗