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Biomedical subjects

A M Moroz

Publications and source records attributed to A M Moroz.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Genetic aspects of experimental tuberculosis in mice].

Susceptibility of inbred mouse strains, their F1 hybrids, offsprings from BC1 and RI strains from CXB pannel to tuberculosis infection was studied. Mice were infected with virulent strain of M. tuberculosis H37Rv. All F1 hybrids, with the exception of (BRSUNT X I/St)F1, showed superresistance, due apparently to heterosis effect; (BRSUNT X I/St)F1 demonstrated an intermediate level of resistance, as compared with parental strains. Analysis of [(BALB/c X B6)F1 X B6]BC1, [(BALB/c X B6)F1 X BALB/c]BC1 offsprings and RI strains indicated that strains BALB/c and B6 have different alleles of at least two genetic loci mediating susceptibility to tuberculosis.

Alleles↗
PubMed1983

[Effect of a specific alloantiserum against T-suppressor cells on the resistance of mice to tuberculosis].

Mouse alloantiserum obtained by immunization of/DBA/2X XB10. A (3R)/F1 hybrids with thymic lymphocytes stimulated with Con A of B10.A(%) mice (anti-I-Jk) was tested in the microcytotoxic assay and in functional test of the survival of mice infected with tuberculosis. Serum was found to react with population of the cells from the lymph nodes of A/Sh, A2G, B10.AKM, and A.TL (I-Jk) mice, and was not active with B10.HTT (I-Js), B10 (I-Jb), B10,D2 (R107) (I-Jb), B6-H-2bm3 (I-Jb). Administration of the antiserum to mice infected with tuberculosis made the survival of the I-Jk-bearing strains significantly longer.

Animals↗
PubMed1982

[Genetic analysis of the factors determining susceptibility to tuberculosis].

An analysis has been made of the inheritance of factors determining varying survival rate in mice of I/st and A2G lines highly differing in sensitivity to intravenous injection with virulent M. tuberculosis strain H37Rv and by the tuberculin tests. It is considered that there exists a diverse genetic control of sensitivity and resistance to tuberculosis.

Animals↗
PubMed1977

In vitro and in viro effects of the fifth thymosin fraction.

Using the 5th fraction of thymosin, it was possible to enhance the capacities of peripheral blood lymphocytes to form rosettes with sheep erythrocytes and to respond to PHA in those cases of cancer or sarcoidosis in which these functions were depressed. Moreover, the 5th thymosin fraction increased the resistance of CBA mice to infection with virulent H37Rv mycobacteria and augmented their ability to acquire delayed hypersensitivity.

Animals↗
PubMed1976

[Lethal infection with BCG in thymectomized mice].

Investigations carried out on CBA mice demonstrated that adult mice to which mycobacteria BCG were injected intravenously 12 months after thymectomy (in a dose of 2 mg for a period of 2 1/2 months) died of disseminated BCG infection against the background of depression of hypersensitivity of delayed type. The usual vaccine process developed in the sham-operated animals.

Animals↗