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Biomedical subjects

A M Lubetkin

Publications and source records attributed to A M Lubetkin.

7 recordsLinked to original sources
PubMedDate not supplied

[Levamisol in the treatment of recurrent urinary tract infections].

Levamisole, a widely used antihelminthic drug, possesses immunotropic properties. It has been proved that children with recurrent infections of the respiratory tract who were given the drug, were capable of preventing the repetition of the infections. Twenty-seven (27) children with recurrent urinary tract infections without structural malformations were studied and in all of them, a diminished cellular immunity was detected (blastic transformation of lymphocytes, rosettes of T lymphocytes and the skin tests). The drug was administered in doses of 2.5 mg/k/day, twice a week, for eight months. During the period of study, in 21 children repetition of the infections were not detected and in 13, a significant improvement of the cellular immunity was achieved. In some children it was possible to prove a rise of the IgA secretary in the urine.

Adolescent↗
PubMedDate not supplied

[Outbreak of hospital infection, due to members of the Klebsielleae tribe, in an intensive care unit for infants].

At the Pediatric Intensive Care Unit of the Provincial Regional Hospital, in Río Cuarto, Argentina, nearly all hospitalized infants showed clinical symptoms of septicaemia and gastroenteritis. Neither Salmonella nor Shigella were found in the stool cultures, but Klebsiella pneumoniae was isolated as predominant flora. Three haemocultures displayed K. pneumoniae and Enterobacter cloacae; the other three developed only E. cloacae. Since the infants came from different places and it was possible to isolate members of the Klebsielleae tribe from all of them, a hospital infection was suspected. Searching for the infectious source, K. pneumoniae was detected in the water bath used to keep the feeding-bottles at 37 degrees C. To clarify the existence of any relationship between the strains isolated from patients and from the water bath, several characteristics were compared: biotypes, haemolityc activity, antibiotic sensibility patterns, and pathogenicity, assessed as lethal dose 50%. Identical results were found for the biochemical tests of all the strains belonging to the same species. The antibiotic sensibility patterns and LD 50% showed quite similar values. All bacteria displayed haemolityc activity for rabbit and lamb erythrocytes. It could be considered that the septicaemia had an intestinal origin, and that the infection spread was due to the contamination of the water bath where the feeding bottles were kept.

Anti-Bacterial Agents↗
PubMedDate not supplied

Antibacterial IgE antibodies in children.

The presence of specific IgE antibodies directed against common microorganisms was analyzed in a population of children. These antibodies included Escherichia coli, Proteus spp., Pseudomonas spp., Klebsiella spp., Streptococcus spp. and Staphylococcus spp. The determination of these antibodies was done by radioimmunoassay. Comparisons were made according to the parameters of age and total IgE levels. These antibodies were found in a high proportion of the cases. Statistical analysis demonstrated that the different specific IgE antibodies were present in all children, none showing special relevance. All of the antibodies studied were found to be present in a higher number of cases in the groups of older children, and in the group of children with increased total IgE levels, a significantly higher number of cases with antibacterial specific IgE antibodies was observed. The presence and the variety of the antibodies might be conditioned by individual as well as environmental factors. The role of antibodies is not well known. Although they are frequently found in allergic children, there have not been enough cases studied to establish their involvement in allergy. Understanding the role of antibodies might be of interest in the study of allergic processes exacerbated by bacterial infections.

Age Factors↗