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Biomedical subjects

A M Kozlov

Publications and source records attributed to A M Kozlov.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Effect of resection of the primary focus on matastasis of transplantable tumors].

The rate of metastasization was estimated by calculating the coefficients of the metastases involved lung mass and the number of metastatic nocules. The experiments with melanoma B-16 and Lewis carcinoma have shown a marked stimulating effect of removing the primary tumor node on metastases growth, the number of metastatic nodules in the lung being less compared with control, but these were larger. In experiments with carcinoma RL-67 the removal of the primary node would not stimulate the growth of metastases. Adenocarcinoma 755 showing no metastases in routine percutaneous inoculation would not give metastases too after the removal of the primary tumor.

Adenocarcinoma↗
PubMed1978

[Frequency, time and type of metastasis of different transplantable tumors in mice].

The character of metastasis of 9 strains of transplantable mouse tumours in conventional subcutaneous inoculation was studied. There were differences in the frequency, intensity, and types of metastasis of different tumours. Periods of onset of metastases of Lewis lung carcinoma and RL-67, and also of sarcoma-37 were established. Sarcoma, Lewis and RL-67 lung carcinomas, adenocarcinoma of the colon AKATOL, Cloudman's melanoma and B-16 metastasized most intensively. Sarcoma-37 metastasizing into the regional and remote lymph nodes, Lewis lung carcinoma and melanomas metastasizing into the lungs, RL-67 lung carcinoma metastasizing into the lungs, kidneys, adrenal glands, ovaries, the heart, and also adenocarcinoma of the colon AKATOL metastasizing into the lymph nodes and the liver can be used as models for the research in the field of drug action upon metastases and the metastasis process.

Adenocarcinoma↗
PubMedDate not supplied

[Biologically active sphingolipids in transplantable tumors of different histogenesis].

The composition of biologically active sphingolipids in hepatoma 22, breast adenocarcinoma, Lewis lung carcinoma, large intestine adenocarcinoma, cervical carcinoma, and melanomas M3 and B16 was compared to elucidate the similarity and differences in sphingolipids of subcutaneously transplantable murine tumors. The sphingolipid composition of the tumors was found to widely vary. The sphingomyelin, ceramide, glucosyl- and lactosylceramide, and ganglioside GD3 contents in hepatoma 22 are higher than those in normal tissue. No common regularities for tumors of different origin were observed in the ratios of bioeffectors inhibiting proliferation and stimulating apoptosis and bioeffectors stimulating cell growth and survival. However, the Cer/(GlcCer + LacCer) ratios were very low and practically equal in two melanoma strains, which probably indicates the degree of tumor malignancy. The results suggest that the content and composition of sphingolipids in tumors depend on their histogenesis.

Animals↗