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Biomedical subjects

A M Kelly

Publications and source records attributed to A M Kelly.

At least 145 records · Page 8Linked to original sources
PubMed1978

Renal tubular function in normal pregnancy.

Maternal plasma and urine concentrations of beta2- microglobulin and gamma-glutamyl transpeptidase (EC:2.3.2.2) were measured serially in normal pregnancy. These parameters remained constant throughout and can therefore be used to evaluate tubular function in pregnancies complicated by renal disorders.

Adolescent↗
PubMed1978

Observations on maternal and fetal ferritin concentrations at term.

The concentration of serum ferritin was measured in 115 paired maternal and cord specimens obtained from patients delivering at term. There was a significantly lower concentration of ferritin in cord serum when the maternal value was 10 microgram/l or less. The maternal ferritin appeared to be lower in mothers who had three or more previous pregnancies or were socially deprived.

Female↗
PubMed1977

Prolactin gonadotrophins in 208 men presenting with infertility.

Prolactin, FSH and LH were measured in the plasma of 208 male partners of infertile marriages. We found 1 case of marked hyperprolactinaemia in 82 oligozoospermic men (1.2%). There was no difference in the mean prolactin levels of men with normal sperm counts and men with oligozoospermia or azoospermia. One-third of the men with azoospermia and with sperm density of less than 10 million had marked FSH elevation and our experience confirms the work of others that this indicates a poor prognosis.

Adult↗
PubMed1977

Ferritin as an assessment of iron stores in normal pregnancy.

In Glasgow, the iron stores in healthy women and in normal pregnant women on prophylactic iron supplementation have been assessed by measurement of plasma ferritin. Ferritin concentration fell progressively to a low level in late pregnancy suggesting that the average iron store was inadequate to meet the demands of pregnancy and that dietary iron supplements were therefore required. There was no evidence that iron supplementation led to excessive iron stores.

Diet↗
PubMed1975

An evaluation of human placental lactogen levels in hypertension of pregnancy.

Maternal plasma levels of human placental lactogen (HPL) are decreased in hypertensive pregnancies and the concentration is related to the severity of the condition. Of infants who had HPL concentrations in the fetal danger zone (more than 2 SD's below normal mean) 75 per cent developed fetal distress, neonatal asphyxia or were light for dates. Patients who are identified in this way have lighter infants and placentae than their unidentified counterparts with normal HPL levels.

Asphyxia Neonatorum↗
PubMed1969

The histogenesis of rat intercostal muscle.

Intercostal muscle from fetal and newborn rats was examined with the electron microscope. At 16 days' gestation, the developing muscle was composed of primary generations of myotubes, many of which were clustered together in groups. Within these groups, the membranes of neighboring myotubes were interconnected by specialized junctions, including tight junctions. Morphologically undifferentiated cells surrounded the muscle groups, frequently extended pseudopodia along the interspace between adjacent myotubes, and appeared to separate neighboring myotubes from one another. At 18 and 20 days' gestation, the muscle was also composed of groups of cells but the structure of the groups differed from that of the groups observed at 16 days. Single, well differentiated myotubes containing much central glycogen and peripheral myofibrils dominated each group. These large cells were interpreted as primary myotubes. Small, less differentiated muscle cells and undifferentiated cells clustered around their walls. Each cluster was ensheated by a basal lamina. The small cells were interpreted as primordia of new generations of muscle cells which differentiated by appositional growth along the walls of the large primary myotubes. All generations of rat intercostal muscle cells matured to myofibers between 20 days' gestation and birth. Coincidentally, large and small myofibers diverged from each other, leading to disintegration of the groups of muscle cells. Undifferentiated cells frequently occurred in the interspaces between neighboring muscle cells at the time of separation. Myofibers arising at different stages of muscle histogenesis intermingled in a checkerboard fashion as a result of this asynchronous mode of development. The possibility of fusion between neighboring muscle cells in this developing system is discussed.

Animals↗