Biomedical subjects

A M Godfrey

Publications and source records attributed to A M Godfrey.

22 records · Page 2Linked to original sources

PubMed1977

Niridazole as an immunosuppressive agent.

The immunosuppressive properties of niridazole, an antihelminthic drug, have been investigated in rats. When given orally at a dosage of 50 mg/kg it extended the median survival of cardiac allografts from 7 to 20 days. The immunosuppressive effect was not increased by giving either azathioprine or prednisolone concurrently, but when all three drugs were combined the immunosuppression was profound, and only 2 of 8 grafts were rejected. Drug combinations incorporating niridazole at a lower dosage or for a shorter period were less effective, and azathioprine and prednisolone on their own or together prolonged graft survival only marginally in this model.

Animals↗

PubMed1976

Radiotherapy in treatment of acute rejection of human renal allografts.

36 patients who received a renal transplant and who subsequently underwent a rejection episode were randomised into two groups. The first group received a standard form of rejection therapy consisting in high doses of steroid drugs, and the second group received in addition 600 rads of radiotherapy to the graft. After three years (minimum follow-up twelve months) the groups were compared with respect to patient and graft survival and level of transplant function. No benefit was obtained by the group receiving radiotherapy.

Acute Disease↗

PubMed1976

Rejection of HLA identical related kidney transplants.

Three cases are described in each of which an HLA identical kidney transplant from a brother was rejected forcefully by the recipient and only one graft survived for more than a year. Rejection of this type is most unusual with well matched grafts and may have been triggered by a system of major antigens that are unassociated with those that are currently recognised.

Adult↗

PubMedDate not supplied

Preclinical detection of metastatic melanoma.

We present a patient with melanoma in whom the performance of combined immunoscintigraphy and immunolymphoscintigraphy indicated the presence of metastatic disease 16 months before clinical manifestation. This approach may be useful in the early detection of metastatic disease and the patient presented is a lesson that cutaneous foci of uptake should not be dismissed as false-positive in the absence of clinical correlation.

Female↗