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Biomedical subjects

A M Geddes

Publications and source records attributed to A M Geddes.

At least 109 records · Page 6Linked to original sources
PubMed1979

Studies with cefuroxime: a new beta-lactamase resistant cephalosporin.

28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages of 750 mg 8 hourly. Biliary excretion was impaired in the presence of obstruction, but adequate bile levels of cefuroxime were observed following relief of the obstruction. Cefuroxime was widely active against gram-negative bacilli and against Streptococcus faecalis, but less active against Bacteroides spp.

Adult↗
PubMed1978

Opportunistic infections in certain non-malignant diseases.

In this paper infections associated with immunological and white blood cell deficiencies are discussed, together with certain aspects of infection in patients suffering from chronic renal failure and other non-malignant disease states. Reference is made to experience of opportunistic infections at East Birmingham Hospital, and certain aspects of the prevention and management of these conditions are outlined.

Bacterial Infections↗
PubMed1978

Renal mobility in women attending a pyelonephritis clinic and in controls.

The range of vertical renal mobility was established in a group of 129 healthy female subjects and compared with the range of mobility observed in 236 female patients attending a pyelonephritis clinic. The mobility was significantly greater on the right side in both groups and both kidneys moved significantly more in the patient group than in the controls. Excessive mobility could not be directly related to bacteriologically confirmed infection, renal pain or IVP abnormality. Nephroptosis remains an enigma and excessive renal mobility must not be interpreted in isolation.

Adult↗
PubMed1978

Studies with cefuroxime and cefoxitin.

We have studied cefuroxime, a new beta-lactamase resistant cephalosporin, and cefoxitin, the first cephamycin antibiotic, which is also resistant to many beta-lactamases. Both of these antibiotics have been shown to be microbiologically superior to the "first generation" cephalosporins, cefuroxime having notable activity against Haemophilus influenzae, and cefoxitin against Bacteroides fragilis. Neither antibiotic is absorbed from the gut but, following parenteral administration, serum, urine and bile concentrations are high. Clinical trials have been conducted on both cefoxitin and cefuroxime. The results of these have been satisfactory and untoward side-effects minimal. We suggest that cefoxitin will be particularly valuable in the management of abdominal sepsis and cefuroxime in infections caused by H. influenzae.

Bacterial Infections↗
PubMed1977

Cefoxitin: a hospital study.

Cefoxitin is a new cephamycin antibiotic that has recently become available for clinical trial. We report here the results of an uncontrolled trial of cefoxitin treatment in 31 hospital patients with various acute infections, 20 of whom were cured. Serum, urine, and bile concentrations of cefoxitin greatly exceeded the minimum inhibitory concentration (MIC) required for clinically important Gram-negative organisms. We conclude that cefoxitin will have a place in the management of serious infections, particularly in the abdominal cavity and renal tracts.

Acute Disease↗
PubMed1977

The treatment of enteric fever with mecillinam.

In vitro studies carried out in this Department confirmed the high activity of mecillinam against Salmonella spp. As a result we set up a study to investigate the efficacy of mecillinam in patients suffering from enteric fever. To date 13 out of 15 patients with typhoid or paratyphoid fever have been successfully treated with this new amidinopenicillanic acid antibiotic.

Humans↗
PubMed1977

Histiocytic medullary reticulosis with hypogammaglobulinaemia and disseminated intravascular coagulation.

A case of histiocytic medullary reticulosis in a 45-year-old man is described. The presentation with a swinging pyrexia is typical. Associated features were very low levels of all immunoglobulins and proved disseminated intravascular coagulation. Heparin therapy was given and the difficulties of controlling such treatment are demonstrated. It is concluded that an increased awareness of the condition as a cause of pyrexia might lead to an improvement in prognosis.

Agammaglobulinemia↗
PubMed1977

Serratia marcescens in a general hospital.

Fourteen patients with infections caused by Serratia marcescens were seen over an eight-month period in a large general hospital. Predisposing factors suggested an 'opportunistic' pattern similar to that previously described in the United States. S. marcescens is an important pathogen which may be increasing in significance in the United Kingdom. Multiple resistance of the organism to antibiotics other than gentamicin makes the finding of apparent sensitivity to co-trimoxazole of potential therapeutic value.

Adult↗
PubMed1977

Bacterial endocarditis in England in the 1970's: a review of 70 patients.

The features of 70 cases of bacterial endocarditis are reported. Streptococcus viridans was the cause in 45 per cent, staphylococci in 27 per cent, and enterococci in 7 per cent. Rheumatic heart disease was the predisposing factor in less than one quarter of patients and in almost half there was no obvious pre-existing cardiac disease. Apart from cardiac murmurs and pyrexia, the classical features of infective endocarditis were uncommon, haematuria being observed in less than one-third. Most patients were over the age of 30, one-third more than 60 years of age and the peak incidence occurred in the seventh decade. The mortality was 34 per cent, being highest in infection caused by Staphylococcus aureus. Adverse prognostic features included cardiac failure, advanced age and peripheral embolization. One-third of infections were caused by bacteria resistant to penicillin.

Adolescent↗