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Biomedical subjects

A M Ermans

Publications and source records attributed to A M Ermans.

83 records · Page 5Linked to original sources
PubMedDate not supplied

[Secondary effects of lithium on thyroid function. Mechanisms, diagnostic and treatment (author's transl)].

The authors reviewed the literature concerning the side effects of lithium on thyroid function. Two kinds of side effects are reported: the first ones are minor, temporary, without important modification of thyroid function and must not be treated; the second ones are major and followed by hypothyroidism. This situation is mostly in relation with the preexistence of an autoimmune thyroiditis or another thyroid abnormality. The authors describe the mechanisms responsible for lithium side effects, suggest different thyroid examinations that should be done in patients before and during lithium therapy and discuss the indications of thyroxine administration.

Humans↗
PubMedDate not supplied

[Goitrogens of vegetable origin as possible aetiological factors in endemic goiter (author's transl)].

Ingestion of unsoaked cassava is followed by an increase of the thiocyanate production in men and in rats. Even a moderate increase of serum SCN concentration induces, in chronic conditions, a clearcut goitrogenic effect characterized by the aggravation of the effects of a preexisting iodine deficiency. The mechanism of the antithyroid action of SCN at low concentrations, lies in an acceleration of the exit rate of thyroidal iodide; this effect cannot be identified by the usual clinical investigation with Iodine131.

Animals↗
PubMedDate not supplied

[Therapeutic indications in hyperthyroidism (author's transl)].

The administration of synthetic antithyroid drugs or of l131, and subtotal resection of the thyroid gland remain the treatments of hyperthyroidism. Precise criteria will determine the choice. Surgery is the treatment of large goitres, of associated ophthalmic disorders and of recurrence after medical treatment. Drugs are indicated at the first occurrence of hyperthyroidism in young subjects with a small goitre; it will also be used as a preparation for surgery associated to Lugol and Levothyroxine. Finally l131 is indicated in medium size hyperthyroid goitres in patients over 45 years. Each treatment has advantages and drawbacks which must be taken into account for the therapeutic choice and the follow-up.

Antithyroid Agents↗