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Biomedical subjects

A M Eber

Publications and source records attributed to A M Eber.

At least 19 recordsLinked to original sources

[Cerebellar cavernous angioma, cervical dystonia and crossed cortical diaschisis].

On four occasions since 1978, this 53 year-old woman presented with a right hemicorporal hypotonia, symptomatic of a hemispheric cerebellar syndrome. In 1981, she experienced the progressive development of a cervical dystonia. CT scan and RM scan showed a cavernous angioma in the right cerebellar hemisphere. The 18F-2-fluoro-2-deoxy-glucose PET scan revealed a right cerebellar and a contralateral cortical and striatal hypometabolism. This crossed cerebello-cortical diaschisis can be interpreted as a functional interruption of the cerebello-cerebral pathways. This case raises the question of the role played by a cerebellar lesion in the development of a focal dystonia.

Cerebellar Neoplasms

[Contribution of MRI to the topography of oculomotor disorders in multiple sclerosis].

Magnetic resonance imaging (MRI) was performed in 20 patients with multiple sclerosis and abnormal electro-oculographic examination. All but 2 patients showed MRI abnormalities in the infratentorial region: hypersignal on T2-weighted sequences and/or images of atrophy. Usually, each patient had multiple abnormalities, which could prevent anatomico-oculographic correlations. With oculomotor disorders of cerebellar origin, correlations between clinical findings and MRI images were satisfactory, but with disorders due to brainstem lesions correlations were not so good, as shown by the results in 9 patients with internuclear ophthalmoplegia.

Adult

[Electro-oculographic study of reading in hemianopic patients].

Recordings of ocular movements during reading in hemianopic patients showed an increase in global reading time related mainly to the increase in number of movements of progression and regression in left hemianopsia and to the time to return to the line in right hemianopsia. Comparison of these changes with those noted in the same patients during recordings of elementary ocular movements and reading simulation suggests that they are not only of a linguistic and/or cognitive type but that they may also be related to altered sensorial data such as size of words or place of spaces between words.

Electrooculography

[Equilibrium disorders, vertigo and nystagmus induced by maximal deviation of gaze. Role of extra-ocular proprioception].

The behavior of 64 normal subjects was studied after they had been submitted to excentric lateral ocular fixation of gaze of more than 40 degrees for periods of one the three minutes. A significant proportion developed vertigo, slow segmental deviations and nystagmus. Nystagmus appearing during gaze fixation (physiological nystagmus of extreme lateral gaze) was distinguished from nystagmus in the opposite direction which appeared after cessation of fixation and was named "post-fixation nystagmus". The possible role of proprioceptive receptors in the extra-ocular muscles is discussed and a hypothesis proposed of an oculo-oculogyric reflex possibly through the vestibular nuclei and influencing the control mechanisms of posture and balance.

Adult

[Fisher's syndrome. Peripheral or central origin (author's transl)].

The syndrome described by M. Fisher in 1956 includes ophtalmoplegia, ataxia, and generalized loss of reflexes. It is classically considered to be of peripheral origin and its relation to Guillain and Barre's syndrome in its mesencephalic form is debatable. The authors review 5 cases and discuss the question of a probable central origin. They base their opinion on the pathognomonic features of these cases and those in the literature, as well as the results of their oculographic and electromyographic studies. They stress the importance of the nature of the ataxia; the severe equilibrium disturbances noted in these patients could result, contrary to usual thinking, more from a central vestibular syndrome than from a cerebellar lesion.

Adolescent

[Opsoclonia: oculographic study].

Oculographic study of a case of opsoclonus associated with infectious meningoencephalitis was used to determine the criteria of definition of this abnormal ocular movement, distinguishing it from the other abnormal movements of flutter and dysmetria. The authors first discuss, on the basis of these recordings, the possible relationship between opsoclonus and myoclonia, and then the role of the cerebellum. The disturbances noted in the course of study of saccadian movement lead them to suggest the hypothesis of overall involvement of the saccadian oculomotor system. They stress the value of oculographic recording in better understanding the general mechanisms of saccadian movement and the pathogenesis of the various changes which may be encountered.

Adult

[Does posterior internuclear ophthalmoplegia exist? A report on eleven cases and the results of oculography (author's transl)].

Based on the anatomical and clinical findings in the very rare cases reported, recent experimental data, and the results of oculography, the authors consider that this condition merits definition as an individual entity. It is usually associated with other disorders of oculomotility which may mask clinical signs, and oculography is necessary to establish the diagnosis. Terminologically, it would appear logical to retain the terms; abduction internuclear ophthalmoplegia (and not, posterior), and adduction internuclear ophthalmoplegia (and not, anterior).

Adult