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Biomedical subjects

A M Cooperman

Publications and source records attributed to A M Cooperman.

At least 19 recordsLinked to original sources
PubMed1992

Proximal femoral bone density and its correlation to fracture load and hip-screw penetration load.

The bone mineral density of 22 random, fresh proximal human femora was estimated by roentgenography using the Singh index (SI) and measured using a regional bone mineral density computed tomographic protocol. Uniaxial compression was used to produce an impacted subcapital fracture. The femoral heads then were isolated and mounted on a sliding screw plate compression device and loaded to failure in a push-out or hip-screw penetration mode. Wide intraobserver variation, poor reproducibility, and poor prediction of the experimental fracture properties of the proximal femur were noted for SI values. Regional bone mineral density provided a reliable estimate of both the gross fracture loads and hip-screw penetration loads. In addition, there was a high correlation between trabecular density and the experimental fracture properties of the proximal femur. Therefore, The validity of the SI as an indicator of the mechanical properties of the proximal femur should be reconsidered.

Biomechanical Phenomena↗
PubMed1991

Gallstone pancreatitis: combined endoscopic and laparoscopic approaches.

Of 11 patients with gallstone pancreatitis, 10 underwent preoperative ERCP. Calculi were removed from the common duct in two patients. All patients underwent laparoscopic cholecystectomy, with normal rapid convalescence. The eleventh patient is recovering from pancreatitis with the bile duct accessed percutaneously. A combined endoscopic and laparoscopic approach to gallstone pancreatitis is safe and was associated with minimal risk in this small series.

Adult↗
PubMed1991

Laparoscopic colon resection: a case report.

The first case of a villous lesion of the colon removed by laparoscopic-guided surgery is reported. Injection of methylene blue into the lesion facilitated its access and exposure via the laparoscope. A very small skin incision allowed delivery onto the abdominal wall for resection and anastomoses.

Anastomosis, Surgical↗
PubMed1991

Laparoscopic cholecystectomy: results of an early experience.

Ninety consecutive patients over a 6-month period with acute (31 patients) or chronic (59 patients) cholecystitis underwent a laparoscopic cholecystectomy on an ambulatory (49 patients), one-night (33 patients), or two-night (5 patients) basis. Three patients required open procedures for 1) perforated duodenal ulcer at 48 h, postoperatively, 2) a cholecystoduodenal fistula, and 3) Mirizzis syndrome with erosion of the common duct. The procedure is safe, efficacious, and should be offered to patients with acute and chronic biliary disease.

Acute Disease↗
PubMed1989

Pancreas divisum--advocates and agnostics.

Pancreas divisum is discussed to define and evaluate criteria for treatment. Selecting candidates for surgery is imprecise since the anatomic anomaly is so prevalent. Endoscopic stenting has been utilized as a therapeutic and diagnostic test. Appraisals of operative results vary depending on length and detail of follow-up. Sphincteroplasty of the dorsal segment is the procedure of choice when the gland is normal--but resection and caudal drainage each have a role, depending on the anatomic and endoscopic findings.

Abdominal Pain↗
PubMed1988

The value of SPECT imaging in the diagnosis of hepatic hemangioma.

Radionuclide flow studies, planar, and SPECT hepatic blood pool imaging were performed in 23 patients with 39 hepatic hemangiomas, 23 patients with primary and secondary liver tumors, 12 patients with hepatocellular disease, two patients with hepatic cysts, and 10 patients with no evidence of liver disease. The hepatic SPECT imaging identified all 39 hemangiomas as having a sequestration pattern compared with a yield of 69% (27 of 39 cases) for the planar imaging. None of the 47 other patients demonstrated this pattern. The SPECT approach is considered superior to planar blood pool imaging because of improved diagnostic yield, reduced patient imaging time, and greater ease of correlation with other cross-sectional imaging modalities.

Adult↗
PubMed1985

Results of conservative operations for breast cancer.

The results of conservative operations for breast cancer in 1,593 patients treated at the Cleveland Clinic between 1957 through 1975 are reported. During this period, we individualized our treatment of breast cancer depending on tumor size, location in the breast, and clinical stage of the disease. The following three principal operations were performed: modified radical mastectomy in 592 patients (37%), simple (total) mastectomy in 442 patients (28%), and partial (segmental) mastectomy in 291 patients (18%). Survival results at 5, 10, and 15 years are reported. Factors important in long-term survival included stage of the disease, number of lymph node metastases, delay in therapy, size of the tumor, histologic type, and estrogen receptor status; type of operation was not a significant factor. In this series, partial (segmental) mastectomy without radiation therapy provided five- to 15-year survival rates equal to modified radical mastectomy and simple (total) mastectomy.

Adenocarcinoma, Mucinous↗
PubMed1979

Nucleation time: a key factor in the pathogenesis of cholesterol gallstone disease.

In earlier studies, we concluded that biliary cholesterol supersaturation may be a necessary but not sufficient cause for gallstone formation. In the present studies, we calculated cholesterol saturation indices (CSI) for 120 bile specimens of cholesterol gallstone patients and controls, using the solubility boundaries of Carey and Small (J Clin Invest 61:998-1026, 1978) for artificial biles. The mean CSI + SD was 1.42 +/- 0.68 for controls and 1.80 +/- 1.02 for cholesterol gallstone patients. Of the control bile samples, 68% were supersaturated. Since the two groups could not be sharply distinguished by saturation index, we studied another property of bile samples: nucleation time for cholesterol crystal formation. The mean nucleation time for 16 control bile samples was 15 days, and a strong correlation (r = 0.84) was found between CSI and nucleation time. Twelve bile samples of cholesterol gallstone patients had a mean nucleation time of 3 days and no correlation between CSI and nucleation time. A discriminant analysis of the data, which took into account both the CSI and the nucleation time for each sample, allowed a sharp distinction between bile samples of cholesterol gallstone patients and controls. This distinction could not have been drawn from studies with artificial biles, since these differ only in their CSI.

Bile↗
PubMed1978

Partial mastectomy.

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Breast Neoplasms↗