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Biomedical subjects

A M Chistiakova

Publications and source records attributed to A M Chistiakova.

At least 19 recordsLinked to original sources
PubMed1990

[Experimental and clinical study of Vasosan P, a new form of pectin-enriched cholestyramine].

The bile acid sequestering agent Vasosan P is a new form of pectin-enriched cholestyramine (20%), saccharose (5%) and sorbic acid (0.18%). In comparison with cholestyramine Vasosan P has a more marked hypolipidemic effect in experiment. Vasosan P is remarkable for good organoleptic properties. It is effective in treating patients with type IIa hyperlipoproteinemia and practically has no side effects as cholestyramine.

Animals↗
PubMed1984

[Effect of arginine on the lipid and lipoprotein content of animal blood].

Arginine decreased cholesterol and triglyceride content in blood sera of intact rats and inhibited the development of hyperlipidemia provoked by Triton WR-1339 injection. In rabbits pretreated with cholesterol arginine diminished the content of blood serum cholesterol and triglycerides. Introduction of arginine to intact and hyperlipidemic guinea pigs decreased the VLDL and increased the HDL level. Under influence of arginine electrophoretic zone of HDL apo A-1 was more pronounced and apo E zone became less distinct in hyperlipidemic guinea pigs.

Animals↗
PubMed1975

[Effect of biologically active compounds on the resistance of bacteria to antibiotics].

A number of biologically active substances, i. e. main protamine proteins and histones, EDTA, lysozyme, methacyl and pentoxyl was studied with respect to their effect on the levels of the minimum inhibitory concentrations of antibiotics against E. coli and Staph. aureus and transfer of resistence to chloramphenicol in E. coli on conjugation. It was shown that the above substances lowered the minimum inhibitory concentrations of the antibiotics 2--10 times when added to the culture simultaneously with the latter. The results varied depending on the strain and the resistance nature. Marked inhibition of transfer of resistance to chloramphenicol in the presence of the main proteins and EDTA was found.

Anti-Bacterial Agents↗
PubMedDate not supplied

[The hypolipidemic action of water-soluble enterosorbents of cholesterol and bile acids in an experiment].

Experiments on rats, guinea pigs and rabbits with experimental dyslipoproteinemia have revealed that the new water-soluble high-molecular weight polymers containing digitonin (ED) or a quaternary nitrogen atom (EA) have a more marked hypolipidemic action than cholestyramine and normalize lipoprotein metabolism. The digitonin-containing enterosorbent has been shown to decrease the absorption of 4-14C-cholesterol, while the nitrogen-containing enterosorbent diminishes the absorption of 3H-cholic acid.

Animals↗
PubMedDate not supplied

[Comparison of lipoprotein spectrum and lipids in maternal blood and in umbilical cord blood of newborn infant].

Content of beta- and pre-beta-lipoprotein fractions, total cholesterol and triglycerides was distinctly lower in blood serum of infant than in maternal one. In serum of funicular blood content of free fatty acids was 2.5-fold higher than in maternal blood serum; in erythrocytes of infant content of cholesterol was found to be higher by 40%, as compared with maternal erythrocytes. In blood serum of infant content of free cholesterol amounted to 28% of the total cholesterol at the same time in maternal blood it was equal to 37%. The highest proportion of cholesterol was found in alpha-lipoproteins of infant, in mother it was observed in beta-lipoproteins. In blood of infant and mother the same types of lipoproteins were present but their quantitative ratio was different. The main lipoproteins of infant were shown to be alpha-lipoproteins. Relationship between the content of cholesterol in pre-beta-lipoproteins (correlation coefficient 0.64) was noted in blood of mother and infant.

Adult↗