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Biomedical subjects

A M Brues

Publications and source records attributed to A M Brues.

At least 19 recordsLinked to original sources

Forensic diagnosis of race--general race vs specific populations.

Commonly used methods of diagnosing racial affinity from the skull may give paradoxical results. This may be due to using single populations to represent large geographical areas, and to the use of measurements unduly subject to local variation. It is suggested that a more flexible approach, using appropriate local populations and selected measurements, would be entirely practical with the use of modern small computers.

Anthropology, Physical↗

Survey of ocular cataracts in radium dial workers.

A survey of the medical records of 813 female radium dial workers first exposed to radium before 1930 yielded reports of 119 cataracts in the group whose radium body burden had been measured at least once. After dividing the subjects into high and low dose groups, the data were analyzed according to latency (time between first employment and first diagnosis of cataract), duration of employment and age at first exposure. Duration of employment and age at employment showed no significant correlation with dose. Latency, however, showed a significant negative correlation with dose. Since radiation cataracts tend to occur earlier than so-called senile cataracts, these preliminary data suggest the need for further investigation.

Adult↗

Breast cancer in female radium dial workers first employed before 1930.

Female radium dial workers first employed before 1930 were analyzed for breast cancer mortality and incidence using method and rate tables described by Monson and the Mantel-Haenszel summary chi-square test for significance. Of 1,180 located women, 736 were measured to estimate radium intake. This measured group was analyzed for breast cancer mortality and incidence according to four possible risk factors: radium intake dose, duration of employment, age at first exposure, and parity. The located women had a mortality ratio of 1.51 (p < 0.05). The measured women showed a significant excess of breast cancer incidence and mortality only among those women with a radium intake of 50 microCi or greater. Although the differences were not significant, incidence and mortality ratios were slightly higher for nulliparous women.

Adult↗

Rethingking human pigmentation.

Though pigmentation has been of interest to anthropologists for a long time, its inheritance, and particularly the reasons for the incomplete correlation of skin, hair and eye, is poorly understood. It is suggested that this is largely due to lack of genetically plausible hypotheses. Taking into account racial and individual variation in pigment traits, and knowledge of pigmentation in other mammals, a minimum set of genetic factors for pigmentation in man is suggested. These include: (1) a set of polygenes affecting skin color only; (2) one locus for depigmentation of the eye, not affecting skin or hair, (3) one pleiotropic gene for reduction of pigment at all sites, and (4) one or more loci with multiple alleles producing blondness or rufosity of the hair in symmetrical patterns over the body.

Eye Color↗