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Biomedical subjects

A M Amin

Publications and source records attributed to A M Amin.

At least 37 records · Page 2Linked to original sources
PubMed1989

Schistosoma mansoni: tegumental surface alterations following oxamniquine treatment of infected mice.

The in vivo effects of oxamniquine on the tegumental surface of adult Schistosoma mansoni were studied using scanning electron microscopy. Pronounced tegumental alterations were observed in all worms including marked oedema, wrinkling and distortion, atrophy, loss of tone and complete disorganization of suckers, blebbing, destruction of tubercles, collapse of sensory papillae and erosion or peeling of the surface layer. The amount of damage was more marked in males than females and varied considerably among worms recovered from the same host and even in different regions of the same worm. Damage was irreversible and all worms were eventually eliminated.

Animals↗
PubMed1988

Susceptibility of Schistosoma mansoni prevalent in Saudi Arabia to oxamniquine in experimentally infected mice.

The therapeutic efficiency of oxamniquine against the local strain of Schistosoma mansoni was investigated in experimentally infected mice. The drug was administered orally using a human-equivalent dose of 20 mg kg-1 day-1 for 3 consecutive days (total dose of 60 mg kg-1). Oxamniquine proved to be very effective as indicated by hepatic shift, oogram changes, complete elimination of adult worms and eradication of faecal eggs.

Administration, Oral↗
PubMed1983

Cytofluorescence localization of adriamycin-binding sites of cardiac tissue.

A study of the cardiotoxicity induced by adriamycin (ADR) was done on the heart tissue of Sprague-Dawley rats receiving a single intravenous dose (15 mg/kg). Condensed bright orange-red fluoresced chromatin was observed in the nuclei of the myocardial cells of the left ventricle 2 h after drug injection. Just then, the intensity of the fluorescence emission started to decrease until it reached its minimum after 21 days, and disappeared completely 28 days after drug injection.

Animals↗
PubMed1983

Immunohistochemical localization of catechol methyltransferase in normal and cancerous breast tissues of mice and rats.

The immunocytochemical localization of catechol methyltransferase was determined in normal and cancerous breast tissues of inbred female Swiss-Webster mice and in normal, lactating, and cancerous breast tissues of inbred Sprague-Dawley rats. The enzyme was found to be cytoplasmically localized in ductal epithelial cells of secretory tubules in both inactive and stimulated mammary glands, in endothelial cells lining blood vessels, in fibroblasts in the connective tissue matrix, and, especially, in tumor cells. Adipose cells were nonreactive. The intensity of the immunocytochemical reaction in tumor cells was stronger than that in lactating tissues, which, in turn, was more reactive than that in normal, unstimulated breast tissues.

Adenocarcinoma↗
PubMed1983

Immunoperoxidase localization of catechol-o-methyl transferase (COMT) in human breast cancer.

Immunoperoxidase reaction of appropriately fixed tissue with an antiserum to catechol-o-methyl transferase (COMT), as the primary step in the peroxidase-immunoglobulin bridge technique, has been utilized for the localization of COMT in biopsy specimens of human breast neoplasm and its metastases. Our immunocytochemical identification of a strong activity of COMT in all cases studied might have a diagnostic implication in breast cancer.

Breast↗
PubMed1982

Cytofluorescence evidence of adriamycin in liver.

Fluorescence study was carried out in Sprague-Dawley rats injected intravenously with the anti-cancer drug adriamycin (ADR) at a dose of 15 mg/kg to determine the site of its localization in liver. Significant fluorescence emission of ADR nuclear-binding appeared in the liver shortly after the drug administration. The occurrence of the nuclear fluorescence in our material was explained by the binding of ADR to DNA. The cytoplasmic drug loading of liver cells might reflect their role in the drug metabolism.

Animals↗
PubMed1978

Studies of estrogen induced renal tumours in male Syrian hamsters. I. Cytochemical studies of lysosomal enzymes acid phosphatase and beta-glucuronidase.

The localization and concentration of lysosomal enzymes acid phosphatase and beta-glucuronidase in kidney cells of Syrian hamsters after DES administration were studied. A positive cytoplasmic reaction was demonstrated for both enzymes. Increased activity of these enzymes were observed in renal tumour in contrast to normal homologous cells. These results can be explained on the basis that lysosomal enzymes were synthesized in tumour cells at a higher rate or it may be due to the invasion of tumour tissue by hydrolase rich microphages.

Acid Phosphatase↗