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Biomedical subjects

A M Alexander

Publications and source records attributed to A M Alexander.

35 records · Page 2Linked to original sources
PubMed1981

The Hereford Hospitals prescribing study. Changes in the prescribing patterns of anti-bacterial agents in the medical wards of a district general hospital over four years.

Analysis of the prescribing of systemic anti-bacterial drugs in the medical wards of a district general hospital from April 1975 to March 1979 showed that 26% of patients received these drugs and that ampicillin, amoxycillin and cotrimoxazole were prescribed much more frequently than other agents. During this time, there were considerable changes in prescribing habits, with increases noted in amoxycillin, flucloxacillin and metronidazole. These changes were paralleled by decreases in ampicillin, cloxacillin and clindamycin usage.

Anti-Infective Agents↗
PubMed1981

The Hereford Hospital Prescribing Study. Investigation of methods to identify patients with adverse drug reactions.

Four investigatory procedures are described for the detection of patients with possible adverse drug reactions. These were evaluated using computer data from the Hereford Hospital Prescribing Study. 120 patients receiving Indomethacin were studied from the total data base of 2,852 admissions during 1977. From this study, two of the methods involving the identification of the discontinuation of drug therapies and the prescribing of 'antidotes' seemed to be the most useful. These methods were also applicable to the routine monitoring of prescription sheets by ward pharmacists.

Adolescent↗
PubMed1979

Interaction of aminoglycoside antibiotics with phospholipid liposomes studies by microelectrophoresis.

Microelectrophoresis was found to be a rapid method for studying the interaction between aminoglycoside antibiotics and liposomes prepared from acid phospholipids. The ability to cause charge reversal of liposomes prepared from phosphatidyl inositol was ranked in the order neomycin greater than gentamicin greater than tobramycin greater than amikacin greater than kanamycin greater than ribostamycin greater than streptomycin greater than dihydrostreptomycin greater than Ca2+. Similar results were obtained with liposomes prepared from a mixture (8: 2) of phosphatidyl choline and phosphatidic acid, but no effect was detectable with neutral liposomes made from phosphatidyl choline only. The results support the view that the attraction between positively charged nitrogen groups on the antibiotics and the negatively charged groups of acidic phospholipids are predominantly responsible for the interaction. Extension of the studies to ionic strengths and calcium concentrations similar to those found in vivo showed a reduction, but not elimination, of the observed effects.

Aminoglycosides↗
PubMed1979

Molluscum contagiosum: the volcano phenomenon.

Molluscum contagiosum, a common cutaneous viral infection, responds to a variety of therapeutic modalities, but patient cooperation often limits the practitioner's choice. In an effort to provide minimally traumatic treatment for a four year old boy with this dermatosis, an interesting phenomenon was chanced upon, which greatly facilitated therapy.

Anesthesia, Local↗