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Biomedical subjects

A M Abrams

Publications and source records attributed to A M Abrams.

At least 37 records · Page 2Linked to original sources
PubMed1985

Oral features of Wegener's granulomatosis.

A review of the dental literature yielded ten cases of Wegener's granulomatosis manifesting in the oral cavity, but only one was found in the medical literature. The most common oral lesion is hyperplastic gingiva, which is red to purple, with many petechiae. Tooth mobility, loss of teeth, and failure of wounds to heal are also common manifestations. The disease may remain localized in the oral cavity for unusually long periods of time before multiorgan involvement occurs. Histologically, oral biopsy tissue does not exhibit the characteristic features of vasculitis and granulomas. There are, however, diagnostic histologic features that are consistently present, including pseudoepitheliomatous hyperplasia, epithelioid histiocytes, giant cells, and eosinophils. Failure to recognize these diagnostic clinical and histologic features resulted in a 24-month delay in the diagnosis and treatment of our patient.

Child↗
PubMed1985

Squamous cell carcinoma of the lip developing in discoid lupus erythematosus.

Since the substitution of steroids and antimalarials for irradiation in the treatment of discoid lupus erythematosus, squamous cell carcinoma arising in discoid lupus erythematosus is thought by some to be an uncommon occurrence. A review of the recent literature (subsequent to 1945) revealed fifteen cases, of which seven occurred in the lips. In one of twelve of the cases a history of irradiation was documented. In three other cases, there was no evidence of its use. We report an additional case of squamous cell carcinoma occurring in the lower lip of a 24-year-old black woman in the absence of radiation therapy. A review of the literature and a discussion of possible predisposing factors are presented.

Adult↗
PubMed1985

Lobular (polymorphous low-grade) carcinoma of minor salivary glands. A clinicopathologic study of twenty cases.

Twenty cases of a recently described adenocarcinoma of minor salivary gland--lobular carcinoma--are reviewed. This distinctive lesion occurs most frequently on the palate of patients in their sixth and seventh decades and displays no apparent sex or race predilection. Histomorphologically, the tumor is characterized by cytologic uniformity, bland nuclear chromatin, and low mitotic rate. Its lobular configuration and marked infiltrative tendency, often by single-filed tumor cells, are reminiscent of lobular carcinoma of the breast. Follow-up data indicate a favorable prognosis and are in accord with findings of previous investigators. The possible relationship of this lesion to adenoid cystic carcinoma is discussed.

Adult↗
PubMed1984

Blueprint for future.

Explore the source record for details and available documents.

American Dental Association↗
PubMed1982

Immunoperoxidase technique in diagnosis of oral pemphigus vulgaris: an alternative method to immunofluorescence.

Five cases of oral pemphigus vulgaris, diagnosed on the basis of clinical, histopathologic, and immunopathologic criteria, were selected. Sections were stained with the peroxidase antiperoxidase (PAP) technique of immunocytochemical staining. The findings correlated well with those reported by direct immunofluorescence demonstrating the same intercellular substance (ICS) pattern of staining. Because this staining technique is applied to routinely processed and paraffinized tissue, it may be of particular value to the oral pathologist who often receives formalin-fixed material before the need for immunopathologic studies is recognized. In addition, interpretation does not require specialized microscopy and tissue sections can be stored and retrieved for retrospective study.

Fluorescent Antibody Technique↗
PubMed1982

Monomorphic adenomas of the major and minor salivary glands. Report of twenty-one cases and review of the literature.

Monomorphic adenomas are benign salivary gland tumors that have a predilection for development in the upper lip and parotid gland. Typically, patients are older persons (mean age, 61 years), but a broad age range (32 to 87 years) has been reported in the literature. Adequate treatment consists of superficial or total parotidectomy (depending on extent and location of the tumor) for parotid lesions and excision with a limited border of normal tissue for minor gland tumors. Uniform cellularity, lack of myxoid or chondroid features, and a tendency for multicentric origin are features which separate these tumors from pleomorphic adenomas. Monomorphic adenomas have been mistakenly diagnosed and treated as adenoid cystic carcinomas. Close attention to cytologic detail, histomorphology, and growth pattern at the periphery are important in separating these tumors.

Adenoma↗
PubMed1981

Malignant fibrous histiocytoma, myxoid variant metastatic to the oral cavity. Report of a case and review of the literature.

Primary and metastatic malignant fibrous histiocytoma (MFH) of the oral cavity is exceedingly rare. A review of the literature yielded only nine cases of primary MFH and no reports of MFH metastatic to this area. We report a case of recurrent malignant fibrous histiocytoma of the myxoid type arising in the soft tissue of the lower extremity and metastasizing to the gingiva as the typical storiform fibrous variant.

Cytoplasm↗
PubMed1980

Juvenile fibromatosis affecting the jaws. Report of three cases.

Juvenile fibromatosis is a clinically aggressive but benign condition which does not commonly affect the jaws. Clinical and radiographic features are not specific, but diffuse lytic destruction of a portion of a jaw, especially the inferior border of the mandible, characterizes many cases. Histopathologic features are consistent and should be carefully observed to avoid a misdiagnosis of sarcoma. Three cases of juvenile fibromatosis affecting the jaws are reported; the patients were alive and well 9, 4, and 5 years, respectively, following therapy.

Alveolar Process↗
PubMed1980

Education in early detection of oral squamous cell carcinoma: a community outreach program.

An educational program consisting of a slide presentation and lecture, a demonstration of how to examine the oral soft tissues, and handout materials was presented to practitioners, hygienists, assistants, and other personnel in their office. A pretest, a critique by the participants, and a follow-up questionnaire were used to determine the value of the program.

Audiovisual Aids↗
PubMed1978

Acinic cell tumors of minor salivary gland origin.

Acinic cell tumors of minor salivary glands are most uncommon. Search of the English language literature revealed twenty previously reported cases. Nine additional cases are newly described. Most patients presented with asymptomatic swellings, but pain and tenderness were experienced by some. Sites of involvement were variable, with the palate, tongue, and floor of the mouth being the most commonly afflicted. One new case occurred centrally within the mandible. There was no sex predominance. A spectrum of histomorphologic characteristics included solid, microcystic, papillary cystic, and follicular patterns composed of acinic, intercalated duct, vacuolated, and nonspecific glandular cells. Follow-up data on ten cases from the literature and the nine new cases revealed that one patient died of tumor, one was alive with distant metastases, and one had been successfully treated for local recurrence. The patient representing the single fatality was treated by irradiation only. Surgical excision with a border of normal tissue seems to be effective treatment. The use of "carcinoma" as an appropriate designation for this neoplasm is questioned.

Adult↗
PubMed1977

Intraosseous benign neural sheath neoplasms of the jaws. Report of seven new cases and review of the literature.

Benign neural sheath neoplasms occurring centrally within the jaws are most uncommon. Our search of the English-language literature revealed twenty-eight previously reported cases. Seven additional cases--five neurofibromas and two neurilemmomas--are newly described here. Most cases have not been associated with multiple neurofibromatosis. These tumors occur predominantly in females, in patients under 45 years of age, and in the posterior mandible. The tumors generally present as asymptomatic radiolucencies, but some are associated with pain and/or swelling. Neurofibromas tend to recur more often than neurilemmomas when treated by conservative local excision.

Adult↗
PubMed1976

Florid osseous dysplasia. A clinical-pathologic study of thirty-four cases.

Thirty-four patients with florid osseous dysplasia were studied. The majority were asymptomatic Negro women: Seventeen biopsy-proven simple bone cysts were found in affected quadrants of fourteen patients. Radiographs displayed a spectrum of sclerotic and ground-glass opacities limited to alveolar processes but not to root apices. Biopsy material was studied in all cases, and biochemical analyses of serum and cyst fluid were performed on some patients. Test results and skeletal radiographs indicate that the disease is limited to the jaws. Patients have remained asymptomatic with little alteration of radiographic patterns. Three cysts failed to heal following treatment, others filled with radiographically abnormal tissue. Chronic osteomyelitis may infrequently complicate the disease. These cases appear to represent the most exuberant manifestation of this reactive fibro-osseous jaw disease.

Adult↗