Search PubMed⌕ Search

Biomedical subjects

A Lypka

Publications and source records attributed to A Lypka.

31 records · Page 2Linked to original sources
PubMedDate not supplied

[Three month treatment with budesonide in patients with corticoid dependent bronchial asthma--personal experience].

The experiment aimed at evaluating a three-month therapy of asthmatic patients with budesonide inhalations. The study involved 32 patients with long-lasting bronchial asthma depended on steroids. Therapy with budesonide (Pulmicort Astra) in a mean daily dose 1.6 mg enabled withdrawal of depot steroids and inhalation treatment only. In patients receiving prednisone in a mean daily dose 5.0 +/- 4.8 mg, budesonide therapy enabled a reduction of the oral dose by 50 percent. A significant improvement in the psychophysical status of patients has been noted despite a lack of significant differences in the results of lung functioning tests. Adverse reactions such as relaxation, insufficiency of the vocal cords at phonation and hoarseness were seen in 20 percent of patients, and in one of them required cessation of the drug. An increase in the number of Candida albicans colonies in throat swabs (over 20 colonies per plate) was seen in 7 treated patients but clinical symptoms which required an additional treatment were noted only in 1 patient.

Adult↗
PubMedDate not supplied

[Free and total thyroid hormone levels after parenteral administration of iodine contrast media].

An effect of the iodine contrast media used in bronchography and urography on both free and total thyroidal hormones was investigated. Hormones concentrations were assayed prior to and 7 and 30 days following an administration of the contrast. Iodine contrast media have no effect on T3, T4, free T3, and free T4 levels. Therefore, one may conclude that the administration of i.v. contrast media containing iodine does not significantly change the results of thyroid hormones assays does not affect an interpretation of the results.

Adult↗
PubMedDate not supplied

[Beta-endorphin levels in the blood and cerebrospinal fluid in humans].

Beta-endorphin concentrations were determined in the cerebrospinal fluid and blood before and after lumbar tap in 19 patients with lumbosacral pains. No statistically significant difference was observed in this concentration before and after lumbar tap, although in individual cases a significant rise of beta-endorphin occurred. The mean beta-endorphin concentration in blood was about twice as high as in the cerebrospinal fluid. No correlation was noticed between the concentration of beta-endorphin in blood and in CSF.

Adult↗
PubMedDate not supplied

The short metyrapone test in chronic headache patients.

The short, overnight, metyrapone test with plasma ACTH and beta-endorphin (beta-EP) determination has been performed in patients with migraine, other forms of headache, and healthy volunteers. A rise in plasma ACTH and beta-EP after metyrapone occurred in all investigated subjects. The rate of increase varied greatly from one individual to the other, but no significant differences between the mean values of plasma ACTH and beta-EP in different groups of headache patients and volunteers were observed. Three months of nadolol therapy in migraine patients caused a significant increase in plasma ACTH and decrease in beta-EP concentrations. Findings support the view that migraine patients do not have a primary dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis as demonstrated by methods currently in use.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Plasma concentration of immunoreactive beta-endorphin in healthy persons during pinpoint stimulation of receptors (acupuncture)].

The participation of the endogenous opiate-like peptide system in the mechanism of the analgesic effect of the stimulation of the peripheral nervous system has been generally accepted but the published results of the investigations on this topic are controversial. The authors studied the plasma beta-endorphin-like activity in 10 healthy subjects before and after pinpoint receptor stimulation (prs). This immunoreactive activity showed fairly high differences in successive determinations but was not significantly different before and after prs. The authors believe that this is an argument against the hypothesis assuming release of pituitary endorphins into the circulating blood after acupuncture but cannot rule out the role of the cerebral beta-endorphin system in the mechanism of acupuncture analgesia.

Acupuncture Therapy↗
PubMedDate not supplied

[Evaluation of the bioavailability of Polfa phenytoin tablets].

Bioavailability of Phenytoin "Polfa" tablets was studied in comparison with Epanutin "Parke-Davis" capsules. It was found that the relative degree of bioavailability of Phenytoin in relation to Epanutin as a standard is 70,7 +/- 6,3% (SD). The cause of worse bioavailability of Phenytoin "Polfa" are differences in pharmaceutical forms of both preparations. The necessity to increase an average dose of Phenytoin "Polfa" tablets is suggested to gain optimal concentration of diphenyl-hydantoin in serum, in therapeutic range.

Adult↗
PubMedDate not supplied

[Plasma beta-endorphins under the effect of pain stimulus. Preliminary report].

Using a diagnostic kit N.E.N. (USA) the authors investigated beta-endorphin-like immunoreactivity in the plasma of young, healthy subjects. It was found that the level of beta-endorphin determined in this way in 10 subjects ranged from 15 to 120 pgml-1 and showed relatively constant values in two determinations carried out at an interval of one hour. Psychological tests showed that subjects with low beta-endorphin level had a low neuroticism index and extra-version, while in the subjects with high beta-endorphin level the neuroticism index was high and introversion features were more prevalent. After application of a painful stimulus (ischaemic test) the level of beta-endorphin changed in most subjects increasing or decreasing. The comparison of the differences in the levels of beta-endorphin immediately before and after the test for pain tolerance suggests that the higher was this difference the lower was pain tolerance and conversely.

Adult↗