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Biomedical subjects

A Lurie

Publications and source records attributed to A Lurie.

At least 91 records · Page 5Linked to original sources
PubMed1980

Congenital adrenal hyperplasia diagnosed in a middle-aged woman.

Short stature, severe hirsutism, an enlarged clitoris and lack of vaginal introitus were manifest in a 55-year-old female karyotype, male phenotype patient brough up as a female. The hormone profile suggested congenital adrenal hyperplasia due to 21-hydroxylase adrenal enzyme deficiency. Follicle-stimulating hormone and luteinizing hormone levels were 122.5 and 100.3 mIU/ml, respectively, within the normal range for a postmenopausal woman. Computerized axial tomography revealed a large cystic tumor connected to the right adrenal gland. Both the right adrenal gland and the cyst were removed. The adrenal cortex showed diffuse hyperplasia and contained a well-defined nodule. The case was interesting because we had the opportunity of examining a patient of advanced age with untreated congenital adrenal hyperplasia and because of the very rare combination of adrenogenital syndrome with nodular hyperplasia and a cystic tumor, which was most probably a degenerated adenoma.

Adrenal Glands↗
PubMed1978

Articular cartilage degradation and the pathology of haemophilic arthropathy.

Synovial membrane and specimens of articular cartilage, obtained from the affected knee joints of 5 haemophilic patients at the time of surgical synovectomy, were studied. All the synovial specimens showed villous proliferation and multiplication of synovial cells. Haemosiderin granules were present within synovial cells and in macrophages. There was congestion and capillary proliferation. An inflammatory infiltrate of plasma cells and lymphocytes was seen in some instances. Articular cartilage changes were classified into the following 4 grades according to severity: 1--an increase in the number of surface chondrocytes with fibrous metaplasia, and the appearance of superficial fissures; 2--a fibrous vascularized overgrowth, resembling rheumatoid pannus; 3--deep fissuring and necrosis of cartilage; 4--erosion and disappearance of articular cartilage with exposure of subchondral bone. In the first 3 grades, deep nests of chondrocytes containing haemosiderin were present. These cell aggregates became larger and more degenerate as cartilage degradation progressed. Damaged articular cartilage was deficient in glycosaminoglycan (acid mucopolysaccharide). No excess enzyme activity could be demonstrated within the cartilage matrix. Immunofluorescent studies were not helpful. Electron microscopical examination revealed siderosomes within degenerate chondrocytes and synovial cells. Granules resembling haemosiderin were also present in the cartilage matrix. It is considered that iron products affect both chondrocytes and matrix adversely and play a part in articular cartilage destruction in haemophilia.

Adolescent↗
PubMed1978

Congregate living for the mentally ill: patients as tenants.

The authors describe an apartment-living project for chronic mental patients released from the Hillside Division of the Long Island Jewish-Hillside Medical Center. The apartments, which are rented by the hospital and sublet to the patients, are located in modern, well-maintained high-rise buildings within commuting distance from the hospital. To avoid creating a psychiatric ghetto, the project rents no more than two apartments in buildings of a hundred or more units. The hospital was able to rent the apartments by assuring the landlords that the hospital would be a financially responsible tenant and that staff would be in continuing contact with the patients, would be available to the landlords if problems arose, and would remove troublesome tenants. Some of the problems encountered by the patients in the program are described, as are guidelines for selecting those who have a reasonable chance of benefiting from such a program.

Adult↗
PubMed1978

Discharge planning.

Explore the source record for details and available documents.

Adaptation, Psychological↗
PubMed1978

Oestrogen-induced bone marrow aplasia in a dog.

A case of oestrogen toxicity in the dog is described. The bone marrow was primarily affected with resultant non-regenerative anaemia, leukocytosis followed by leukopaenia, and thrombocytopaenia. Endometritis, toxaemia and disseminate intravascular coagulation were complicating factors. The case terminated fatally intensive therapy.

Anemia, Aplastic↗
PubMed1977

Haemophilia.

The clinical and haematological features of haemophilia are reviewed and the historical aspects, pathogenesis and genetics are discussed. The problems associated with management, such as factor replacement, home therapy, physiotherapy, surgical intervention and the presence of inhibitors, are fully described. Finally, mention is made of the psychological problems of haemophiliacs and of the help given by the South African Haemophilia Foundation.

Antibodies↗
PubMed1977

Social work in health care in the next ten years.

The social worker in health settings in the future will have more medical knowledge that affects his practice, be a more active psychosocial counselor, and be prepared to work in group practice that includes a number of disciplines. The social work department of the future will be organized in a more decentralized fashion, and will develop stronger links to other clinical and administrative departments within the medical center, to departments of social work of other medical centers, and particularly with community groups outside of the hospital. The department will need to assign manpower expertise in such areas as knowledge of changing social and welfare systems, legislation affecting programs, as well as in research, computerization, data gathering, and retrieval.

Ambulatory Care↗
PubMed1976

Staffing patterns: issues and program implications for health care agencies.

Unsolved staffing pattern issues are viewed in the current context of funding pressures, third party payment, and management necessity for program and cost projections. Relevant factors are mustered for consideration with their implications. Use of differentiated skill levels and response as well as development of departmental services mandate are considered. The author also shares his experientially derived thoughts on staff ratio to certain institutional assignments.

Educational Status↗
PubMed1976

Cation exchange resin and calcium excretion. An experimental study.

It has been suggested that cation exchange resins might be helpful in urinary stone prophylaxis. The effect of the cation exchange resin Dowex 50 WX8 upon calcium absorption and urinary excretion in guinea pigs was investigated. The mean fecal calcium concentration was very close in the Dowex-treated and control animals and the urinary calcium concentration was not reduced in the resin-treated animals. These findings suggest that Dowex was ineffective in binding calcium in the gastrointestinal tract.

Animals↗
PubMed1976

Transplant nephrectomy and simultaneous second graft retransplantation.

Tranplant nephrectomy and retransplantation has become an established modality in treating patients with rejected kidney allografts. Experience with 29 patients who underwent simultaneous transplant nephrectomy and retransplantation is presented. This procedure did not involve a considerably greater risk than a primary transplant and had an almost equal rate of success. There was no significant correlation between survival or failure of the second graft and the time the patient had been on dialysis prior to the first transplant, the duration of first graft survival, or the source of the first or second kidney. Seventy-five percent of the failures in the second transplant group were due to hyperacute or accelerated rejection, and only 25% were rejected in an acute or chronic fashion. The high frequency of hyperacute and accelerated rejections is presumably a result of presensitization by the first transplant. An inadequate supply of cadaver kidneys prevented performance of the simultaneous procedure in all patients that required it.

Adolescent↗
PubMed1975

Haemophilia home infusions with dried fresh plasma.

A group of 26 haemophilic patients was successfully managed on a home infusion programme over a one-year period. Single donor units of dried fresh plasma, the coagulant activity of which was adequate to ensure haemostasis of most of the haemorrhagic episodes treated, were used. The transmission of hepatitis was kept to a minimum by careful selection of regular, known donors and by the utilisation of single donor units of plasma in preference to plasma pools. Although the programme was costly, it was less expensive than it would have been had alternate antihaemophilic products been used. The advantages and disadvantages of self-administration are discussed. No serious mishaps occurred, and the programme was considered an outstanding success by both laymen and medical personnel. Minor alterations in liver function tests were demonstrated in several of the recipients. No factor VIII inhibitors were detected.

Antibodies, Viral↗