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Biomedical subjects

A Luo

Publications and source records attributed to A Luo.

35 records · Page 2Linked to original sources
PubMed1997

[Application of rigid bronchoscopy in airway management after lobectomy of lung].

OBJECTIVE: Application of rigid bronchoscopy in airway management after lobectomy of lung was recommended, and its significance was discussed. METHODS: Bronchoscopies were performed in three patients scheduled for lobectomy of lung undergoing epidural plus general anesthesia. Each patient was examined two times. The first examination was done after anesthetic induction and intubation. The second was given at the end of operation. RESULTS: Rigid bronchoscopy under general anesthesia could clearly show the inner structures of trachea, bronchi and location of carcinoma. Under direct version, the secretion and sludged blood in the trachea and bronchi after lobectomy could be scavenged. CONCLUSION: It was suggested that with the use of bronchoscopy the complications including postoperative atelectasis and bronchial-pleural fistulization could be reduced.

Adult↗
PubMed1997

[Quantitative electroencephalogram monitoring the depth of anesthesia during skin incision].

We investigated the EEG parameter changes of skin incision during different depth of sevoflurane/nitrous oxide analgesia. 65 ASA physical status I patients (aged 34 +/- 12 yr) scheduled for elective abdominal surgery were studied. The tracheal of each patient was intubated and the lungs were ventilated. Patients were randomly assigned to one of three groups. Anesthesia was maintained with 1% (group I n = 25), 1.5% (group II n = 20) or 2% (group III n = 20) end-tidal sevoflurane concentration in 66% nitrous oxide. Each of the concentration levels was maintained for at least 15 minutes before surgical incision. The EEG electrodes were placed on each patient in a front-oparietal montage (Fp1- A1, Fp2- A2) referred to Cz. EEG was recorded during 3-min period before incision. Hemodynamic variables were also monitored. Inadequate anesthetic depth was defined as patient movement in response to a 5-cm skin incision. The ventilation was controlled to maintain normocapnia (PETCO2 5 +/- 0.04 kPa). The data were analysed using ANOVA, liner correlation analysis and t-test. A significant difference between EEG parameters (SEF, BIS,) and skin incision responsive rate were found among the three concentration groups (P < 0.01). There were no difference of hemodynamics among the three groups. Patients who moved at incision also had significantly higher SEF, BIS leveles compared to non-movers (P < 0.01). Quantitative EEG determinants were correlated well with the end-tidal sevoflurane concentration and were a useful predictor of patient movement in response to skin incision during sevoflurane/nitrous oxide anesthesia.

Adolescent↗
PubMed1997

Changes on receptor expression and production of interleukin-2 in circulating lymphocyte population after open heart surgery.

To evaluate the change of perioperative cell mediated immunity after cardiac operation with cardiopulmonary bypass (CPB), so as to provide some information for timely prevention and treatment against postoperative immunological disorder, 40 patients were studied. By searching for the effects of CPB and anesthesia, interleukin-2 receptor (IL-2R) expression upon the surface of peripheral blood mononuclear cells (PBMC), as well as interleukin-2 (IL-2) production in vitro was traced 55 min after anesthesia, at end of CPB, on postoperative 1, 7, and 14 day versus preanesthesia control. Our data demonstrated that expression of IL-2R on PBMC was significantly suppressed in all comparing with the baseline value, meanwhile, IL-2 production in vitro also statistically dropped. However, no statistical difference was found on perioperative IL-2R expression and IL-2 synthesis in the cholecystectomy group. We conclude that postoperative immunological disorder seems to be the main factor, which could be denoted as reduced IL-2R expression on PBMC and IL-2 synthesis in vitro for sepsis, even multiple system organ failure developed after cardiac surgery.

Adolescent↗
PubMed1997

Expression of the spinach betaine aldehyde dehydrogenase (BADH) gene in transgenic tobacco plants.

Plasmid pLS9 contains a 1.5-kb of spinach cDNA including its complete open reading frame. The 1.5-kb BADH cDNA was cut from pLS9 using restriction enzyme and was inserted into the expression cassette of plasmid pYH between the CaMV 35S promoter and polyA signal sequence. The 35S-BADH cDNA-polyA fragment of pYH was cloned into a polylinker cloning site of the binary vector pBin19. The resulting plasmid pBinBADH-S was transferred to Agrobacterium tumefacies LBA4404. The tobacco plants were transformed with strain LBA4404 containing pBinBADH-S, and more than ninety kanamycin-resistant transformants were selected. Polymerase chain reaction (PCR) detection showed that more than 60% of the transformed tobacco plants contained the foreign BADH gene. The Western blot analysis, BADH enzymatic assay, specific stain for BADH activity, and the test for salt tolerance showed that BADH gene was normally expressed in the transgenic tobacco plants. The BADH enzymes also presented in chloroplasts and cytosol of the transgenic plants. The transgenic tobacco plants having strong expression of BADH gene had strong ability to tolerate high salt stress.

Aldehyde Dehydrogenase↗
PubMed1996

[The effects of cardioplegia and reperfusional blood containing captopril on myocardial ultrastructure alterations after cardiac arrest].

OBJECTIVE: To investigate the myocardial protective effect of captopril on the ischemia and reperfusion injury in the canine heart. METHODS: Twelve mongrel dogs were randomly divided into control and captopril groups. In the former, only modified St. Thomas cardioplegia was used, and in the latter, modified St. Thomas cardioplegia and reperfusional blood containing 4.6mumol/L captopril were used. Sixty minutes after reperfusion, myocardial renin activity (MRA), angiotensin II (AII) and melondyldialdehyde (MDA) content in myocardium were measured, and the subendocardial myocardium of the left ventricle was taken for electromicroscopy. RESULTS: The MRA in the Cp1 group was significantly higher than that in the control group (P < 0.01), while the AII and MDA content in the myocardium in the Cp1 group were significantly lower than those in the control group (P < 0.01). Electronmicroscopically, the damage of the myocardium including sarcomeres, mitochondria and microvascular endothelial cells were less obvious in the Cp1 group than that in the control. The mitochondrial average cross-section area and average volume (0.59 +/- 0.15 micron2 and 0.74 +/- 0.23 micron3) in the Cp1 group were significantly lower than those in the control (0.83 +/- 0.34 micron2, P < 0.01 and 1.1 +/- 0.4 micron3, P < 0.01). The numerical density (0.46 +/- 0.16 micron-3), specific surface of mitochondria (6.4 +/- 1.1 microns-1) and memberance density of mitochondrial cristae (21 +/- 10 microns-1) in the Cp1 group were significantly higher than those in the control (0.29 +/- 0.06 micron-3, P < 0.05, 4.8 +/- 0.8 micron-1, P < 0.01 and 15.3 +/- 2.0 microns-1, P < 0.01): CONCLUSION: Cardioplegia and reperfusional blood containing 4.6 mumol/L captopril could effectively protect the myocardial mitochondria and microvascular endothelial cells against ischemia and reperfusion injury.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1995

[Clinical research of muscular relaxation induced by alcuronium and pancuronium].

The clinical experiment was designed for observing effect of muscular relaxation induced by alcuronium and pancuronium. 40 patients were randomly divided into alcuronium group (A) and Pancuronium group (P). A group and P group were redivided into A1,A2 groups and P1,P2 groups according to differences of the initial doses of muscle relaxants. The results of neuromuscular monitoring indicate that onset time and main-tenance time of 0.3 mg/kg alcuronium were respectively 2.4 min and 63 min; 0.1 mg/kg pancuronium were 2.7 min and 70 min. The initial doses mentioned above are suitable to intubation of anesthesia and meet surgical need for muscular relaxation. The changes of MAP,HR,blood kalium and natrium were not evident in statistical significance before and after administration of relaxants.

Alcuronium↗
PubMed1995

A comparison of the effects of the propofol versus midazolam during total intravenous anesthesia for gynecological surgery procedures.

The effects of propofol and midazolam as an intravenous anesthetic were compared in 40 ASA I-II patients undergoing gynecological surgery during total intravenous anesthesia (TIVA). They were divided into propofol group (P n = 20) and midazolam group (M n = 20) randomly. The anesthesia was designed for each group respectively. Here, we discuss the experimental method and the results, which indicate that propofol is not only an effective anesthetic but also has more rapid and head-clear recovery properties than midazolam.

Adult↗
PubMed1995

Hospital information systems in China.

The hospital information system (HIS) is an important aspect of computer application in hospitals. China is a developing country, and its HIS has been in the process of being developed since the 80s. In this paper the process of developing the HIS in China is reviewed. By comparing it with the developed countries, we found some existing problems in the HIS. The key problem for us is to design and implement a Chinese HIS. Backward models need to be discarded and new ideas of development encouraged.

China↗
PubMed1994

Influence of alloferin on neuromuscular function in myasthenia patients undergoing thymectomy.

Myasthenia gravis patients are hypersensitive to nondepolarizing relaxants, such as alcuronium, an intermediate-long nondepolarizing agent. This study observed the effects of alcuronium treatment in myasthenia gravis patients as compared with non-MG patients during operation. Ten MG patients (Ossermann class I-IV, scheduled for thymectomy) and 10 non-MG patients (ASA class I-II, scheduled for operation) were selected. An induction dose of alcuronium 0.2 mg/kg and thiopental 4-6 mg/kg was given, followed by intubation and ventilation with 50% nitrous oxide in oxygen and 0.5-1.5% ethrane. Neuromuscular transmission was monitored using an accelerograph and degrees of neuromuscular function at different depths were recorded. There were statistically significant differences between the two groups. The effect of alloferin in the MG group was quicker and deeper. This study also found a relation between MG class and the recovery of respiration: Respiratory recovery was quicker in classes I-II than in classes III-IV.

Adult↗
PubMed1993

Preliminary report on cardiovascular responses to urapidil during intubation and extubation.

Urapidil (Ebrantil), a new antihypertensive agent with central and peripheral sites of action, has proven effective in the management of both chronic and acute hypertension. This study investigates its effects on cardiovascular responses during intubation and extubation under general anesthesia. Thirty normotensive patients (ASA I-II) were randomized into control (I, without urapidil, n = 10); lower dose (II, 0.4 mg/kg, n = 10); and higher dose (III, 0.6 mg/kg, n = 10) groups. A significant fall of blood pressure was observed in all patients within 1 min after urapidil administration (P < 0.05), and the magnitude of the decrease was related to blood pressure before treatment. However, no transient drop of blood pressure to hypotensive values was observed. The results suggest that urapidil could be used under general anesthesia in patients to control fluctuating blood pressure during intubation and extubation. The increased heart rate (P < 0.05) seen for several minutes after urapidil administration may have been due to the patients' hypovolemic state.

Adolescent↗
PubMed1991

Midazolam as a main anesthesia induction agent--a comparison with thiopental and diazepam.

A clinical randomized investigation was undertaken to determine the value of midazolam as a narcotic adjuvant for anesthetic induction. Thirty ASA I-II adult patients undergoing selective surgery were allocated randomly into two groups to receive one of the following agents: midazolam 0.3 mg/kg, thiopental 5 mg/kg, or diazepam 0.4 mg/kg. The induction time as measured from the onset of injection to loss of the eyelash reflex was shortest in the case of thiopental; while a lower frequency of apnea, lesser suppression of circulation, and lack of venous irritation were points favoring midazolam. However, further study is needed to clarify the moderate cardiovascular response seen during intubation in some cases as well as to elucidate any patient population differences.

Adams-Stokes Syndrome↗
PubMed1991

Anesthesia for primary hyperparathyroidism.

We review the anesthesia used on patients with primary hyperparathyroidism from 1980-1989. As the first choice, nearly two thirds of the operations were performed under cervical epidural block, and about 90% of these obtained satisfactory results. Injury of the spinal cord and nerve root could be avoided by accurate insertion of the epidural needle. Respiratory depression might also be minimized with an alert perioperative course of 5 ml 0.8-1.33% lidocaine as the initial dose followed by 6-8 ml for maintenance. For complicated cases, such as those who had undergone previous cervical operations or were suspected of having ectopic parathyroidomas, general anesthesia was carried out instead.

Acupuncture Analgesia↗
PubMed1990

Anesthetic management for the excision of pheochromocytoma.

Anesthetic experiences involving 23 patients with pheochromocytoma during the period 1983-1986 are reported. Typical clinical symptoms and positive laboratory results were found in all patients. Epidural block was used in 11, general anesthesia in 10, and a combination of the two in 2 cases. Swan-Ganz catheter was used to monitor hemodynamic changes during anesthesia and surgery. Before excision of the tumor, a larger volume of fluid was transfused than was lost, resulting in the elevation and/or maintenance of pulmonary arterial pressure (PAP) and pulmonary capillary wedge pressure (PCWP) at the upper limit of the normal range. Once venous supply was secured, the incidence of critical hypotension following resection of the tumor was reduced significantly. But it was difficult to avoid this blood pressure drop in some cases, and intravenous infusion of catecholamines was required. After tumor excision a marked decline of myocardial function was observed. This suggests that myocardial dysfunction might be another important factor of severe hypotension, along with the total peripheral resistance (TPR) decrease and relative hypovolemia. Blood pressures of patients undergoing epidural block were stable or slightly decreased during the establishment of anesthesia. However, in all cases of general anesthesia a variable hypotension was observed during induction and intubation. We therefore recommend epidural block for abdominal pheochromocytoma resection in order to avoid the marked fluctuation of blood pressure which may accompany the induction of general anesthesia.

Adolescent↗