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Biomedical subjects

A Luft

Publications and source records attributed to A Luft.

11 recordsLinked to original sources
PubMed1988

[Value of the measurement of cerebral blood flow in choosing the operative time of ruptured intracranial aneurysm].

The authors report a series of 135 patients treated between 1984 and 1987, for a ruptured intracranial saccular aneurysm in the Department of Neurosurgery at the Lariboisiere Hospital. The value of C.T. scan and cerebral blood flow measurements (C.B.F.) in predicting the development of vasospasm was studied on 99 cases. The analysis confirmed that the C.T. Scan findings are closely related to vasospasm. A low C.B.F. between the fourth and the eight day following the bleeding was significantly associated with the development of delayed cerebral ischaemia. On the contrary, no relation was found between vasospasm and the C.B.F. measured during the three days following the bleeding. The authors propose to operate without delay on clinical grounds on patients referred during the first three days after the hemorrhage and to decide, on clinical and C.B.F. data, the timing of the intervention for patients admitted after this data, i.e. 35% of their patients.

Cerebral Hemorrhage↗
PubMed1987

[Study of the cerebral blood flow by intravenous injection of xenon-133 in thalamic and juxtathalamic lesions].

Sixteen patients with subcortical vascular lesions of one hemisphere, (7 left, including 4 aphasics and 9 right, 4 of which had a left neglect syndrome) and 4 controls without noticeable cerebral pathology underwent cerebral blood flow (CBF) measurements with intra-venous Xe 133, both at rest and during activation. The latter consisted of listening to a text together with eye opening and was considered non specific. At rest, a non significant CBF lowering on the side of the lesion was found in most patients, mainly in right brain damaged ones. Hypoperfusion areas (HA) were noted, predominantly in parieto-temporal cortex in right lesions, and in lower and middle frontal areas as well in left lesions. HA persisted during activation on both sides, except on the right side in left damaged patients. Activation resulted in a bilateral and roughly symmetrical mean CBF increase, which was not significant in left lesions nor in controls, but was significant (p less than .05) in right brain damaged patients without neglect syndrome. Conversely, patients with right lesions resulting in left neglect exhibited conspicuous mean CBF asymmetry during activation with depression on the right side. Right-left difference in mean CBF was significantly higher in this group than in right sided lesions without neglect (p less than .05). These facts are consistent with an activation imbalance between hemispheres as the mechanism of unilateral neglect syndromes, and support the view that right subcortical pathways and especially the thalamus, play a part in the activation of both cerebral hemispheres.

Adult↗
PubMed1979

Measurement of regional cerebral blood flow by intravenous injection of Xe133.

Clearance of Xenon 133 following intravenous injection has been used to perform atraumatic measurements of regional cerebral blood flow (rCBF). rCBF was computed by a two-compartmental analysis of the clearance curves associated with a correction for Xenon recirculation based on the end-tidal tracer concentration. Direct comparison was made between the results of this method and those obtained from the reference intracarotid method. A systematic analysis has shown that the results of the non-invasive method depend on the part of the clearance curves chosen for computation of rCBF. The best concordance with the intra-carotid method was found when the analysed part of the curve was situated between 3 and 11 min. after the beginning of the injection. Under these conditions, the differences between the results from the two methods did not exceed 10% of the flow values even for low flows. Such precision makes the atraumatic measurements of rCBF by intravenous injection of Xenon valuable for clinical applications.

Cerebrovascular Circulation↗