Biomedical subjects

A Lucas

Publications and source records attributed to A Lucas.

At least 397 records · Page 22Linked to original sources

PubMed1977

[Comparative bioavailability of three pharmaceutical forms of digoxin].

The bioavailability single doses (0.5 mg) from three preparations of digoxin is compared in a crossover study in nine normal volunteers. Plasma digoxin concentrations from 0 to 72 hr and urinary glycoside excretion for 96 hr are measured by radioimmunoassay. Areas under the plasma concentration-time curves are assessed according to two different statistical methods, one comparing preparations, the other comparing subjects. With the first, bioavailabilities are similar; with the second, they significantly differ. On the other hand, urinary excretions do not differ. This discrepancy is probably related to different kinetics of digoxin release from the pharmaceutical preparations, the total amount absorbed being equivalent.

Administration, Oral↗

PubMed1976

[Pharmacokinetic characteristics of a massive dose of furosemide in acute kidney failure].

A pharmacokinetic study with high doses of frusemide has been performed in nine patients with acute tubulopathy, treated by hemodialysis. The patients were studied between 6 and 28 days after the beginning of the disease. Renal function was normal before the episode of acute renal shutdown. The diuretic effect of frusemide was closely related to creatinine clearance (Ccr): no effect in anuric cases, moderate effect if Ccr was lower than 10 ml/mn, marked effect if Ccr was higher than 10 ml/mn. no direct relationship could be demonstrated between drug plasma level and natriuresis. Frusemide half-life in plasma was short even in anuric patients, suggesting the existence of an extra renal excretion and/or inactivation pathway. Hence toxic side effects due to drug accumulation should not appear in the recommended 1 g/day regimen.

Acute Kidney Injury↗

PubMed1975

[The student, the cetacean and swine-fever. A minor epidemic after dissection of a globicephale].

A whale (Globicephalus melas), stranded on the north coast of Finistere, was the origin of a minor epidemic of Baker-Rosenbach erysipeloid. The clinical picture was that usually seen after contamination by marine animals (spiny fish, crabs, molluscs). To our knowledge, this is the first time that a marine mammal has been found to be infected by Erysipelothrix rhusiopathiae.

Animals↗

PubMed1975

[The toxicity of different crude oils on mussel larva].

Five natural oils of varied origins, mixed with sea water by stirring, have been shown to be toxic for mussel larvae, which have been contaminated during one hour. This toxicity, expressed by the mortality percentage and the growth rate after contamination, was dependent on the type and the concentration of oil. The tests were carried out on 20 h old and 5 days old larvae, and were similar and complementary.

Animals↗

PubMed1974