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Biomedical subjects

A Lozano

Publications and source records attributed to A Lozano.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Non-pigmenting cutaneous-mucosal fixed drug eruption due to piroxicam.

BACKGROUND: Piroxicam is a widely used anti-inflammatory drug. Most adverse reactions affect gastrointestinal system, liver and skin. Fixed drug eruption although very unusual, has also been described, but with cutaneous involvement exclusively. We present the case of a 49-year-old man who suffered three episodes of fixed drug eruption with cutaneous-mucosal involvement, even simulating an autoimmune disease, whenever he was treated with oral piroxicam. METHODS AND RESULTS: He was patch tested on normal skin with the GEIDC standard series and an NSAIDs series. He was patch tested on normal skin and on fixed eruption with piroxicam, meloxicam and tenoxicam (all of them 1 % pet). Oral challenge test was not performed due to the severity and reproducibility in previous reactions. Results showed a positive patch test to piroxicam (1 % pet) on fixed eruption, with negative results to the rest. CONCLUSIONS: Adverse drug reactions may present a wide variability of clinical symptoms. In these situations an accurate clinical history is necessary. To our knowledge this is the 1st report of non-pigmenting fixed drug eruption with cutaneous-mucosal involvement due to piroxicam. Cross-reactivity between oxicams could not be demonstrated by patch test on fixed eruption.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

An unusual adverse drug reaction?

INTRODUCTION: Adult Still Disease (ASD) is a rare (incidence 1-1,6/1,000,000 in Europe) seronegative polyarthropathy diagnosed with clinical criteria, excluding other etiologies. Minocycline, a semisynthetic derivative of tetracycline, has been associated with many adverse effects. We present the case of a 18-years-old man with a high suspicion of an adverse drug reaction (ADR), that was finally diagnosed of ASD. MATERIAL AND METHODS: In order to exclude other diseases, laboratory test, radiology and allergological studies were performed. The results of the allergological studies excluded the possibility of an ADR. The rest of the results determined the diagnosis of ASD. CONCLUSION: It's necessary to emphasize the importance of an accurate differential diagnosis in cases like this, because many diseases may mimic an ADR, and may be underdiagnosed (or misdiagnosed).

Adolescent↗
PubMedDate not supplied

[Surgical treatment of dystonia].

INTRODUCTION AND DEVELOPMENT: Dystonia is a neurological syndrome which is often progressive and disabling. The pathophysiological basis is only partly understood. Medical treatment often fails. Peripheral surgical techniques can alleviate the symptoms of many patients with diverse forms of focal dystonia. In patients with generalized dystonia, central surgical techniques are preferable. Thalamotomy is the best known technique, although the target is not fully defined. Experience with surgery of the pallidum and subthalamus is very limited, but results are promising. CONCLUSIONS: More studies are necessary to discover the precise potential benefit of these techniques and define the ideal candidates. It is important that such studies should be done using rigorous methodology and be similar for all groups working on this.

Dystonia↗
PubMedDate not supplied

[Endoscopic retrograde cholangiopancreatography and sphincterotomy in parasitic diseases].

We report six patients with billary duct obstruction due to parasites (Fasciola hepatica, ascariasis and hydatid cyst) that were diagnosed and managed with the endoscopic approach. This is the first national paper which highlights the importance of endoscopic retrograde cholangiopancreatography in the management of this parasitosis. Despite choledocholithiasis as the most common cause of extrahepatic jaundice, biliary tree parasitosis must be considered in the differential diagnosis.

Adolescent↗
PubMedDate not supplied

[Nonbacterial thrombotic endocarditis related to hepatocarcinoma].

A case of a woman with nonbacterial thrombotic endocarditis (NBTE) associated with hepatocarcinoma is here presented. Epidemiologic and clinicopathologic aspects are reviewed, early clinical suspicion may prevent embolization. it represents the first case reported in the national literature.

Aged↗
PubMedDate not supplied

[The neurobiology of developmental dyslexia: a survey].

One of the most common disorders affecting the ability to read is developmental dyslexia, which, unlike the alexia related to a loss of the capacity to read associated with brain damage, refers to a specific disorder in the acquisition of reading skills and becomes apparent in reiterated persistent difficulties in learning to read. A number of studies have attempted to detect structural and functional abnormalities that might be the origin of problems in learning to read. The use of functional neuroimaging techniques such as positron emission tomography (PET), spectroscopic magnetic resonance imaging (SMRI) and functional magnetic resonance imaging (fMRI) enables us to measure changes in the metabolic activity associated with alterations in the neuronal networks involved in the reading process. In this review, different studies are analysed in an attempt to identify alterations in the cortico subcortical regions which could be the origin of the developmental dyslexia. Results show that in dyslexics there is a temporoparietooccipital disconnection, and a disconnection with the left frontal cortex as regards the demands for fast auditory processing, as well as abnormalities in the connections between the temporoparietal cortex and the cerebellum with other regions of the brain. Such findings suggest that the altered areas of the brain do not only show a characteristic pattern of hypoactivation, but also that these alterations could be the cause of this malady. We highlight the importance of these findings in the diagnosis and rehabilitation of this population.

Dyslexia↗
PubMedDate not supplied

[Radial nerve injury caused by external compression during the dissection of the internal mammary artery in coronary surgery].

Injury of the radial nerve produced by external compression during dissection of the internal mammary artery during surgery of ischemic heart disease, is an infrequent event. The use of sternal retractors with only one rod may be the cause of these lesions. We report two cases of radial nerve paralysis produced as a consequence of external compression induced by a sternal retractor during dissection of the internal mammary artery. In the first case the patient showed loss of power of the external muscles of the left forearm and a clear flexion of the left hand. The second patient presented loss of power of the left hand and impossibility to extend the carpus and fingers. In both cases the lesion was reversible.

Equipment Design↗
PubMedDate not supplied

[Myokimia induced by gold salts].

We report a 44 year old male suffering from rheumatoid arthritis that developed myokymias when treated with gold salts. Myokymia is a clinical phenomenon characterized by involuntary repetitive contractions of muscle fibres, which give an undulating appearance to the overlying skin, last a few seconds, and with a typical electromyographic activity described as myokymic discharges. The difference between the single twitch of the fasciculation and the tetanic contraction of myokymia may be evident only on electromyography in difficult cases. Neurological complications associated with gold are infrequent, and they include myokymia, peripheral neuropathy, Guillain-Barré syndrome, cranial nerves paralysis and encephalopathy.

Adult↗
PubMedDate not supplied

[Epidemiologic study of an outbreak of echovirus type-9 meningitis].

BACKGROUND: Several agents are able to produce lymphocytic meningitis, but sometimes it's not possible their identification. The viruses are the etiological agents more frequently found, especially enteroviruses, mumps virus and herpes simplex virus, with different epidemiological patterns depending on time and geographic location. Most of the infections caused by enteroviruses are asymptomatics. In general the viral meningitis have a good prognostic with an acute benign course and serious signs of neurological affectation are infrequent. From 1991 it has been observed an increase of nonpolio enteroviral meningitis outbreaks in our Country. Echovirus-4 was isolated in most of the outbreaks notified during that year. Echovirus-9 was not isolated in any of them. METHODS: We describe the epidemiological and clinical characteristics of a lymphocytic meningitis outbreak that took place from June to July of 1993 in Burgos. RESULTS: Forty-eight patients, most of them children, were hospitalized with fever, headache, vomits and stiff neck with an increase in the total cell count in cerebospinal fluid (CSF). Echovirus-9 was isolated from fecal samples in eight patients. CONCLUSIONS: The etiology was attributed to Echovirus-9 because of microbiologic and epidemiologic findings. The incubation period can fluctuate between four an five days and fecal-oral transmission is the most probable mechanism.

Adolescent↗
PubMedDate not supplied

[Peutz-Jeghers syndrome. Apropos a familial case at Hospital Arzobispo Loayza].

The Peutz-Jeghers syndrome is a rare dominant autosomic, entity characterized by hyperpigmented lesions on the lips, hands and feet; with presence of gastrointestinal polyps producing acute or chronic anemia, intestinal obstruction, and/or abdominal pain. This polyps histologically are hamartomas; recent studies indicate a real risk for transformations in the malignant neoplasia. The high and low endoscopies and the intraoperative enteroscopy with polypectomy are the election treatment, improving prognosis quality on these patients. We describe a familiar case of a female patient 24 years old showing a repeated picture of intestinal subocclusion; her brother presented a similar clinical picture, and her mother presented the same syndrome, dying of carcinoma in the colon; also her child, at one and a half year old presented hyperpigmented lesions on the lips.

Adult↗