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Biomedical subjects

A Lorber

Publications and source records attributed to A Lorber.

At least 55 records · Page 3Linked to original sources
PubMed1987

The value of electrocardiography in patients with right ventricular endocardial pacemakers in the diagnosis of left ventricular hypertrophy: a correlative study of pace electrocardiography and left ventricular mass derived from M-mode echocardiography.

This study evaluated 51 patients with permanent apical right ventricular endocardial pacemakers. The assessment of the diagnostic value of pace electrocardiograms for the determination of left ventricular hypertrophy revealed specificity of 94% and sensitivity of 66%, applying a new parameter: RL1 + SV3 greater than or equal to 30 mm. The application of this criterion in the interpretation of pace electrocardiograms correlated well with values for the left ventricular mass derived from M-mode echocardiograms (r = 0.644, P less than 0.0001).

Aged↗
PubMed1987

Quinidine-induced torsade de pointes suppressed by paroxysmal atrial fibrillation.

A 74-year-old patient is presented in whom quinidine-induced torsade de pointes was abolished by the onset of atrial fibrillation with a fast ventricular response. Heart rate acceleration during atrial fibrillation shortened the Q-T interval from 0.68 on admission to 0.44 milliseconds when sinus rhythm was re-established. This resulted in the suppression of paroxysms of polymorphous ventricular tachycardia.

Aged↗
PubMed1987

Transient complete atrioventricular dissociation and asystole following junctional premature beats in a patient with acute myocardial infarction.

A 58-year-old patient is presented with recurrent episodes of complete atrioventricular dissociation and asystole which followed junctional premature beats during the acute phase of myocardial infarction. This uncommon electrocardiographic phenomenon occurred when junctional premature beats interfered with the conduction in a previously compromised atrioventricular node, leading to the above-mentioned electrocardiographic phenomenon.

Arrhythmias, Cardiac↗
PubMed1987

Autosomal dominant inheritance of sinus node disease.

A family with sinus node disease is presented. The mother was severely affected by sinus bradycardia and required a permanent atrial pacing system. The father is asymptomatic and has no evidence of conduction disturbances. All their offspring (one son and two daughters) are affected with variable degrees of severity. The occurrence of the disease in this family is suggestive of autosomal dominant inheritance with variable penetrance.

Adolescent↗
PubMed1987

Atrioventricular block complicating dissecting aneurysm of the aorta.

A 67-year-old patient who presented with acute dissecting aneurysm of the aorta was complicated by progressive transient atrioventricular heart block. Post-mortem examination findings confirmed the diagnosis of dissection of the ascending aorta and revealed an interatrial haemorrhage in the area of the septal atrioventricular junction.

Aged↗
PubMed1987

Pacemaker Twiddler's syndrome.

The pacemaker Twiddler's syndrome was recognized in a patient who presented with dizziness due to failure of his recently implanted endomyocardial permanent pacemaker system. Electrocardiographic, X-ray and intraoperative findings are presented.

Aged↗
PubMed1987

Gold pharmacokinetics in breast milk and serum of a lactating woman.

During 20 weeks of aurothioglucose therapy, gold in a mother's serum and breast milk and her nursing infant's serum and urine were measured. The mother's steady state plasma gold was 4.05 mg/l; it was 0.041 mg/l in breast milk. Only 0.0255 mg gold appeared in the breast milk/24 h. We calculated that only 0.1785 mg gold (0.71% of the weekly dose) would appear in the breast milk over a week. No gold (less than 5 X 10(-7) mg/l) was found in the infant's plasma or urine. It is very unlikely that more than minute amounts of gold are absorbed from the mother's breast milk when breast feeding an infant.

Adult↗
PubMed1986

Balloon aortoplasty for recoarctation following the subclavian flap operation.

Transluminal balloon aortoplasty was successfully performed 7 times in 5 children between 3 and 14 months of age who had had the subclavian flap operation for coarctation of the aorta in the neonatal period. In two the balloon aortoplasty was performed twice. All recoarctations presented with upper limp hypertension and marked upper to lower limb pressure gradients. The pressure gradient decreased immediately after the procedure from 57.1 +/- 13.8 mm Hg to 17.9 +/- 15.5 mm Hg, P less than 0.001. The diameter of the recoarcted region increased from 2.67 +/- 1.0 mm to 3.85 +/- 1.23 mm, P less than 0.05. There were no complications attributable to the dilatation technique. Intermediate term success was unpredictable from the initial results or the angiographic appearance of the recoarctation. Follow-up has been for an average of 12.7 months (range 2-30 months). Four patients have pressure gradients from upper to lower limbs of 20 mm Hg or less. In one this has been achieved by repeat balloon aortoplasty. Severe restenosis has occurred in one other patient despite repeating the angioplasty. The procedure is safe and although intermediate term success cannot be predicted in all cases, we propose that balloon aortoplasty be the initial treatment of choice for recoarctation of the aorta. The place of repeating the procedure when early restenosis occurs has yet to be defined.

Angioplasty, Balloon↗
PubMed1986

Double aortic arch associated with coarctation.

An unusual combination of double aortic arch with coarctation of one of its limbs is described. We emphasize the importance of preoperative aortography to demonstrate or exclude coarctation which is clinically silent prior to surgery. This rare association will determine the surgical approach.

Aorta, Thoracic↗
PubMed1985

Superiority of radionuclide over oximetric measurement of left to right shunts.

In 100 children with suspected left to right shunts the ratio of pulmonary to systemic flow was measured both by oximetry and first pass radionuclide angiography. The pulmonary time activity curve from the radionuclide study was analysed by the method of gamma variate fits. There was strong correlation between the two techniques; weaker correlation was found when the shunt was at atrial rather than ventricular level. This difference can be explained only by problems with the oximetric rather than the radionuclide technique. Although there are important limitations to the radionuclide method, it is the more precise and less invasive of the two and is to be preferred when the accurate measurement of left to right shunts is required.

Adolescent↗
PubMed1985

Insufficiency os pubis fractures in rheumatoid arthritis.

There is a paucity of information regarding insufficiency fractures of the os pubis in rheumatoid arthritis. While only 7 such fractures have been recorded thus far in the English literature, we have encountered 5 os pubis fractures in the past 4-year period. We report these cases to heighten awareness of their existence, describe their sometimes misleading clinical presentations, and to discuss possible etiologic factors.

Aged↗
PubMed1983

Thoracic outlet syndrome mimicking angina pectoris with elevated creatine phosphokinase values.

Four patients with elevated creatine phosphokinase (CPK) values and recurrent chest pain were found to have thoracic outlet syndrome. This association of abnormal CPK levels and chest pain due to thoracic outlet syndrome has not been previously reported. Symptoms and CPK values improved with anti-inflammatory medications and/or proper posture instruction. It is proposed that CPK values become elevated by ischemic or neurologic compromise of muscles supplied by the subclavian artery or brachial plexus respectively. Accordingly, chest pain in the same dermatomal distribution as that of angina pectoris may be simulated by ischemic skeletal muscle. Thoracic outlet syndrome therefore should be suspected in any patient with chronically abnormal CPK values and chest pain in whom no other etiology can be determined.

Adult↗
PubMed1983

I. Unbound serum gold: procedure for quantitation.

The unbound fraction of many drugs appears to be the therapeutically active component. However, the major problem encountered in following unbound serum gold (UBSG) concentration during chrysotherapy has been the ability to quantitate such a small quantity of gold reliably without matrix interference. The methodology detailed here overcomes these difficulties and provides an effective means of monitoring the UBSG fraction during chrysotherapy. We have observed that the unbound fraction of gold dissipates quickly after gold sodium thiomalate administration and constitutes less than 2% of the total serum gold concentration.

Arthritis, Rheumatoid↗
PubMed1983

II. Unbound versus total serum gold concentration: pharmacological actions on cellular function.

Unbound serum gold (UBSG) has received little attention, possibly because of rapid in vivo decay and in vivo concentration below the range of existing analytical procedures. We have recently developed a methodology enabling quantitation and study of UBSG during chrysotherapy to assess effects on cellular functions. UBSG after gold administration is labile, declining rapidly after attaining peak values at which lymphocyte mitogen response and polymorphonuclear phagocytosis were observed to be suppressed. Oral gold, i.e., auranofin, 3 mg BID as compared to systemic chrysotherapy 50 mg/wk, resulted in a higher percentage of UBSG to total serum gold.

Anti-Inflammatory Agents↗