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Biomedical subjects

A Lodi

Publications and source records attributed to A Lodi.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Oxatomide in the treatment of pruriginous skin diseases of various nature].

A study in two parts was carried out with the aim of developing a formulation of oxatomide for topical dermatological use. During the first part of the study the safety of 4 formulations (cream and gel at 2.5% and 5%) was evaluated by means of the patch-test, while in the second a clinical trial was carried out in order to assess the anti-itching efficacy of the formulation chosen on the basis of the results of the first part (gel 5%). During the double blind study of safety, only one patient out of 33 studied showed a reaction, and with all formulations. In the second part of the study 30 patients (16 F, 14 M) were admitted, aged between 13 and 77 years (mean age 48.2) and suffering from cutaneous diseases with itching. The study was open and each subject applied oxatomide gel at 5% twice a day for 14 days. There was a subsequent follow-up without therapy of 14 days. During the study a significant (p less than 0.01 between times) improvement in lesions was observed, with an average reduction of 61% for itching, 54% for erythema, 60% for excoriations and 59% for lichenification. Acceptability and safety were good. Only one subject suspended treatment due to the onset of burning on the site of application. In the follow-up period the therapeutic results achieved were generally maintained.

Adolescent↗
PubMed1990

[Chronic urticaria and allergy to Acari. Experience with a specific desensitization therapy].

Eighty-five patients affected by chronic urticaria (45 females and 40 males) were submitted to intradermal tests with house and storage mites in order to evaluate a possible sensitization to these allergens. The same allergological tests were performed in an 80-subject control group. The results showed immediate cutaneous reactivity to one or more mites in 40 patients (47%) while only 6 positivities (7.5%) were found in the control group. 27 patients, out of the 40 allergic to mites, were submitted to specific desensitizing therapy. 6 of them showed a complete recovery, 20 good results and only 1 slight improvement of clinical manifestations. These data allow us to hypothesize that the allergy to mite allergens is an important etiopathogenic factor in several chronic so called "idiopathic" urticarias.

Adolescent↗
PubMed1987

A comparative study on peripheral blood lymphocyte subpopulations in different kinds of warts.

Peripheral blood T-cell subpopulations were evaluated in 36 patients with clinically different types of warts, subdivided in 4 groups (common, genital, flat and plantar warts). A significant decrease was found in OKT3 and OKT4 subsets total count and in OKT4/OKT8 ratio in patients with common and genital warts as compared with controls. Only in common and genital warts did we also observe a significant decrease of percentage of OKT4 subset. No significant difference of considered parameters was observed in flat and plantar warts as compared to controls, apart from a significant increase in number of OKT8 subset in flat warts. We then discuss this different status of C.M.I. in patients with different clinical warts, stressing the importance of various types of HPV.

Adolescent↗
PubMed1987

Evaluation of efficacy and tolerability of K-FA fluocinolone acetonide tape.

In order to assess the efficacy and tolerability of a fluocinolone acetonide tape (8 micrograms/cm2), 30 volunteer out-patients, 11 females and 19 males, mean age 43.4 years, affected by different kinds of dermatoses were treated. The tape was applied once or twice daily for an average period of 9.3 days. At the beginning and the end of the treatment, detailed dermatological and blood chemistry examinations were performed in all the patients. The clinical results were excellent for all the dermatoses treated. Itching at the site of application was reported by two patients and slight atrophy was observed in one patient. The patients' compliance was excellent. The blood chemistry tests showed no significant variation.

Administration, Cutaneous↗
PubMed1987

Allergy to house dust and storage mites in children: epidemiologic observations.

One hundred and fifty-two children affected by respiratory syndromes, probably due to allergy, underwent skin testing to a range of extracts including several different species of mites. The incidence of positive reactions to different allergens was studied in two groups: below and over 4 years, each including both outpatients and inpatients. The aetiologic role of mites has been evaluated considering positive skin tests to single species between and within families.

Animals↗
PubMed1986

[Psoriasis and day hospital. Clinical and therapeutic considerations concerning 104 cases].

One hundred and four patients with psoriasis, treated in regimen of Day Hospital, have been examined. The diagnosis was widespread plaque type psoriasis (67.3%), guttate psoriasis (18.3%) and nail psoriasis (1.0%). Furthermore psoriatic erythroderma has been observed in 2.9% and pustular psoriasis of Barber in 1.9%. 10% of the patients showed psoriatic arthritis. 71.2% of the patients have been successfully treated with UVB and PUVA irradiation therapy (respectively 86.6% and 70.0% of complete clearing or marked improvement). Etretinate and topical therapy were successful (respectively 67.0% and 70.0% of complete clearing or marked improvement). Day Hospital has proved to be the ideal regimen for the treatment and control of psoriatic patients.

Administration, Topical↗
PubMed1986

[Sexually transmitted infections in patients with condylomata acuminata].

42 patients (26 males, 16 females) with genital and perianal warts were submitted to serological testing for HBV markers, anti HSV antibodies and syphilis. Specimens were also collected for microscopic and cultural examination for Neisseria gonorrhoeae, Chlamydia Trachomatis, Trichomonas vaginalis, Candida albicans and other pathogenic bacteria from urethra in men and from urethra, vagina and cervix in women. Women had also cytologic examination from cervix with Papanicolau method. We have found an high incidence of urethral and vaginal asymptomatic infections, of positivity for HBV markers and some positivities of tests for syphilis. Importance of these screening examinations in the management of patients with genital warts is then discussed.

Adult↗
PubMed1986

Peripheral blood lymphocyte subpopulations in patients with viral warts.

Peripheral blood T-cell subpopulations were evaluated in 32 patients affected by viral warts and in 32 unaffected individuals belonging to a control group. A significant decrease was found in total lymphocytes as well as OKT3 and OKT4 subsets among affected patients. A significant negative correlation was also found between OKT3 and OKT4 numbers as well as OKT4/OKT8 ratio and duration and extent of lesions. A significant positive correlation was found between the duration and the extent of lesions and the percentage of OKT8 subsets, but not the total number of OKT8. These data confirm that a cell-mediated immune deficiency is present in patients with viral warts. We then discuss whether the decrease of cellular immunity in these patients is a primary event or, rather, the result of persistent verrucosis.

Adolescent↗
PubMed1985

[Skin pathology caused by drugs].

175 patients suffering from acute drug-induced skin pathologies were examined with particular reference to age of onset, clinical type and causative agent. The most common pathology was urticaria, followed by eczematous and exanthematic eruptions. The drugs most frequently responsible for such reactions were the analgesic-antipyretic-anti-inflammatory group, topical products and antibiotics. These data are discussed in detail.

Adolescent↗