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Biomedical subjects

A Lindner

Publications and source records attributed to A Lindner.

At least 217 records · Page 12Linked to original sources
PubMed1981

Duplication of the kidney: a potential diagnostic pitfall.

Nine patients with marked vesicoureteral reflux into a contracted, pyelonephritic kidney were found at time of surgery to have complete duplication of the affected side. Eight of them also had an ectopic ureterocele. The radiological diagnosis of duplication was virtually impossible as all these kidneys showed reflux nephropathy and were smaller than the contralateral kidney. The surgical management is briefly outlined.

Adult↗
PubMed1980

Scaphoid megalourethra: a report of 2 cases.

Two cases of scaphoid type megalourethra are reported. Both patients had upper urinary tract dilatation and in one of them massive vesicoureteric reflux was demonstrated. The urinary tract in one patient returned to normal after correction of the megalourethra. The second infant, who had vesicoureteric reflux underwent ureteric reimplantation as well as correction of the deformed urethra. A description of the surgical technique and clinical and radiological follow-up is given.

Dilatation, Pathologic↗
PubMed1980

Septic arthritis in hemodialyzed patients.

Six episodes of septic arthritis involving 5 patients and eleven joints were documented in the last 7 years in a population receiving 450 patient-years of dialysis treatment. The same micro-organisms were often cultured simultaneously from the joint, blood and/or arteriovenous fistula, suggesting hematogenous spread. A tendency toward multiarticular involvement was also observed. Early diagnosis is mandatory to avoid severe joint damage. Since such patients have other potential causes of arthritis and periarticular pain not due to infection, it is important to culture the joint fluid promptly whenever the possibility of infection exists.

Adult↗
PubMed1980

[Optimizing the fibrinogen-thrombin adhesive system].

It was the aim of the present three series of investigations to determine conditions to improve the firmness of the clot produced by the fibrinogen-thrombin adhesive system. For methodological reasons the compressive strength and adhesive power of the clot, as well as the probability of a relation between deformation energy and tensile strength were examined. Furthermore, the influence of fibrinolysis on the effects of the adhesive system was investigated. The following factors proved to be relevant for the firmness of the clot: 1. Concentration of fibrinogen, 2. concentration of thrombin, 3. relation between volume of fibrinogen and of thrombin solution, 4. time of diffusion of constituents of mixture, 5. addition of blood-clotting factor XIII and solution of calcium ions. The following optimum concentrations of components of the adhesive system per ml of the mixture were established in the course of the investigations: Fibrinogen solution (approx. 10% clottable material) 0.86 ml Thrombin 100 E. Factor XIII 90 E. = 30 mg Ca++ 250 mMol A volume ratio of 6 parts of fibrinogen as cryoprecipitate to 1 part of a solution containing thrombin, factor XIII and calcium ions proved optimal for the preparation of the mixture.

Animals↗
PubMed1979

Synergism of dopamine plus furosemide in preventing acute renal failure in the dog.

The protective effects of a combination of dopamine and furosemide were studied in dogs during the initial phase of acute renal failure (ARF) induced by intravenous uranyl nitrate (10 mg/kg). Fifteen minutes after injection of the nephrotoxin, and infusion of dopamine (3 micrograms/kg/min), furosemide (1 mg/kg/bolus followed by 1 mg/kg/hr), or both drugs simultaneously were given for 6 hours. Exogenous creatinine clearance was measured for 6 hours, and the intrarenal blood flow was measured with radioactive microspheres before and 3 hours after the induction of ARF. Treatment with both dopamine and furosemide produced renal vasodilatation, high urine flow rate, and attenuation of the fall in GRF seen in untreated animals. In contrast, single use of dopamine or furosemide was totally ineffective in producing renal vasodilation, a diuresis, or the maintenance of the GFR. These data indicate that dopamine plus furosemide have a synergistic effect in preventing the early pathophysiologic changes associated with ARF in this animal model. Maintenance of a high GFR correlated best with the enhancement of solute excretion and urine flow rate. Potential protective effects of dopamine plus furosemide in other models of ARF deserve careful investigation.

Acute Kidney Injury↗
PubMed1978

Propranolol effects in long-term hemodialysis patients with renin-dependent hypertension.

We evaluated propranolol effects on blood pressure, plasma renin activity, and erythrocyte production in nine chronically hemodialyzed and four nondialyzed patients with hypertension and high plasma renin concentrations. Propranolol, at a maximum daily dose of 240 mg, controlled blood pressure in 12 of the 13 patients. During propranolol treatment of dialyzed patients, mean blood pressure fell from 133 +/- 1 to 113 +/- 4 mm Hg (P less than 0.005) and plasma renin activity from 3093 +/- 423 to 689 +/- 218 ng/dl 3h (P less than 0.001). Similar results were obtained in nondialyzed patients. In both groups hematocrit and red cell mass were unchanged, although ferrokinetic measurements suggested a decrease in erythropoiesis. Thus propranolol alone reduces blood pressure and renin activity in chronically dialyzed patients with hypertension and high renin concentrations. No hematologic complications or other side effects were observed. These findings suggest that propranolol may be an effective alternative to bilateral nephrectomy in the control of renin-dependent hypertension in selected patients.

Adult↗
PubMed1977

Peutz-Jeghers polyposis with metastasizing duodenal carcinoma.

A case of Peutz-Jeghers polyposis associated with duodenal carcinoma but without cutaneous pigmentation was presented. Duodenal carcinoma is the most commonly associated neoplasm. The presence of vitiligo in this patient is coincidental. Of 14 reported cases of Peutz-Jeghers syndrome associated with intestinal carcinoma, in only two was the tumor shown to originate in the polyp. In our case, too, we believe the carcinoma developed independently.

Adenocarcinoma↗