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Biomedical subjects

A Ligeziński

Publications and source records attributed to A Ligeziński.

At least 19 recordsLinked to original sources

[Alpha-fetoprotein--diagnostic utility in squamous cell carcinoma of the head and neck].

The authors present results of evaluation of alpha-fetoprotein (AFP) in 146 persons (108 patients with head and neck carcinoma and 38 healthy persons as control group). We analyzed a concentration of AFP in preliminary study and in monitoring depending on clinical advances of tumour, mass of primary tumour and metastases to lymph nodes. Our results indicate that evaluation of AFP have not high value in diagnostic procedures and monitoring patients with head and neck carcinoma.

Adolescent↗

[Allergology in internet].

The authors present all-Polish Internet Allergy Service www.allergen.info.pl working since February 1998. The system of mailing current allergenic pollen data to individual patients is presented. The results of Internet questionnaire filled by 4500 users of GlaxoWellcome Pollen Count Internet Service in 1998 are discussed. The authors also present possibility of cooperation for clinicians with the usage of IRC and picture and voice transmission.

Allergy and Immunology↗

[Squamous cell carcinoma antigen (Scc-Ag): diagnostic utility in squamous cell carcinoma antigen of the head and neck with metastasis to lymph nodes].

Aim of the work was estimation of squamous cell carcinoma antigen (SCC) concentrations in serum and qualification its diagnostic value in patients with malignant neoplasm of head and neck in dependence from presence of metastasis to lymphatic glands. The study comprised the group of 146 persons (108 with head and neck malignant neoplasm, 38 of persons determined group supervisory). At 35 ill one ascertained metastasis to lymph nodes. In presented work sensitivity of SCC in initial investigation was (52.8%), specificity (97.4%), positive predicting value (PV+ = 94.2%) and negative predicting value (PV- = 64.0%). We observed not characteristic statistical dependence of concentrations SCC from presence of metastasis to lymph nodes. There was characteristic correlation between concentration of SCC and presence of metastasis to regional lymphatic glands using of correlation R-Spearman.

Adolescent↗

[Serum levels of tissue polypeptide antigen in patients with the head and neck cancer according to presence of metastases in lymph nodes].

Aim of the work was estimation of Tissue Polypeptide Antigen (TPA) concentrations in serum and qualification its diagnostic value in patients with malignant neoplasm of head and neck in dependence from presence of metastasis to regional lymph nodes. The study comprised the group of 146 persons (108 with head and neck malignant neoplasm, 38 of persons determined group supervisory). At 35 ill one ascertained metastasis to lymph nodes. In presented work at ill without metastasis to lymphatic glands sensitivity of test TPA carried out 28.8%, and at ill with metastasis 42.9%, attaining 66.7% at ill from N3. One showed, that concentrations TPA grow together from spreading of neoplasm in lymph nodes, and presence of metastasis correlates with concentrations of TPA.

Adolescent↗

[Lymph nodes metastases as a first sign of cancer].

The authors present three cases of cervical lymph nodes metastases from unknown primary lesion as a first and single sing of cancer. In follow-up the primary lesions of cancer was recognized (tonsil, hypopharynx, parotid gland). Presented patients pass through combined treatment: chemotherapy, radiotherapy and surgery with good results. Patients are in follow up of ENT Department.

Adult↗

[Diagnostic value of osteotropic bone scintigraphy in maxillary sinus diseases].

The authors described the application of facial bone scintigraphy in 6 patients with acute and 47 patients with chronic sinusitis, 4 patients with cyst of maxillary sinus, 4 patients with sinus maxillary neoplasm and 4 patients with pyocele of frontal sinus. Facial bone scintigraphy was performed by gamma-camera Siemens Gammasonics ZLC-750 after intravenous administration of 15 mCi of 99mTcMDP in anteroposterior projection. The index of accumulation of the tracer (JAT) in maxillary sinus region was counted separately in men and in women in the reference group. In patients with purulent sinusitis marked JAT was predominated. Correlation between JAT and symptoms and rhinological signs has been shown in patients with chronic purulent sinusitis. In patients with sinus maxillary neoplasm high JAT was predominated.

Adult↗

[Surgical treatment of rhinophyma using CO2 laser].

The authors present the method of combined treatment of rhinophyma (surgery and laser CO2). The advantages of this method are good cosmetic result, small intraoperative bleeding and short time of healing the wound.

Aged↗

[Squamous cell carcinoma antigen for monitoring patients with head neoplasm].

The authors present results of evaluation of squamous cell carcinoma antigen (SCC) in 73 persons (35 patients with head carcinoma and 38 healthy persons as control group). We analysed a concentration of SCC in preliminary study and in monitoring, depending on clinical advances of tumour, mass of primary tumour and metastases to lymph nodes. We observed high sensitivity (SE) (63%), high specificity (SP) (97.4%) and predictive values: positive PV(+)--95.6%, negative PV(-)--74% of SCC in preliminary study. These values changed to SE--83.3%, SP--92.3%, PV(+) 90.9%, PV(-)--85.7% in monitoring. Our results indicate that evaluation of SCC have high value in monitoring patients with head carcinoma.

Adolescent↗

[Gastrointestinal cancer antigen and immunoglobulins G, A, M in patients with head cancer].

The authors present the results of examinations of immunoglobulins A, G, M serum concentrations and of a sensitivity of test of biochemical tumor marker (Ca 19-9) in a group of 35 patients with head malignant tumors. There was a statistically significant increase of immunoglobulins IgA, IgG and decrease of immunoglobulin IgM. We observed statistical correlation between serum concentrations of IgA, IgG and serum concentrations of IgA, IgM. The sensitivity of Ca 19-9 was 23% in the preliminary study. The values of Ca 19-9 changed in monitoring of tumors to 26%. There was a statistically significant correlation between sensitivity of Ca 19-9 and serum concentration of IgM. We did not observe any statistical correlation between Ca 19-9 and the age of patients.

Adolescent↗

[Sarcoidosis of the paranasal sinuses].

The authors described diagnostics difficulties, clinical features and treatment of this disease. The treatment is insufficient, but only interventional, although the clinically dominating symptoms may be due to a chronic disease inside of the sinuses and they are known to be caused by specific disorders in immunology. Immunosuppression, using prednisone, and reestablishing sinus ventilation and drainage via natural ostia is the basis of treatment, but it does not lead to recovery. Two rare cases of paranasal sinuses sarcoidosis are described.

Adult↗

[The value of gastrointestinal antigens in the monitoring of patients with malignant head neoplasms].

The authors present the results of examinations of test on the sensitivity of biochemical tumor marker (Ca 19-9) in a group of 35 patients with head malignant tumors. The sensitivity (SE) of Ca 19-9 was 22.9% in preliminary study. The values of Ca 19-9 changed from 22.9% to 25.9% in monitoring of tumors. Positive predictive value (PV+) and specify (SP) were 100% in preliminary study and in monitoring. Negative predictive value (PV-) was 50.9% in preliminary study and 51.6% in monitoring. In 25 patients we observed changes in examined parameters: SE--35%, SP--100%, PV(+)--100%, PV(-)--42.1% in monitoring. Our study indicates that serum levels of Ca 19-9 were higher in patients with head tumors than in control group. The surgical treatment of tumors didn't change the values of Ca 19-9.

Adolescent↗

[Use of long-acting drainage (sino-ject) in treatment of chronic maxillary sinusitis].

The authors present the results of treatment of chronic maxillary sinusitis with punctures and with permanent drainage (sino-ject). The use of permanent drainage shortened the time of treatment and increased percentage of very good results of treatment. Presented method of permanent drainage of maxillary sinus avoid many punctures of sinus. The drainage of sinus allow for each day rinsing of sinus with physiological saline and with drugs (mucolitic, antibiotic) and also for bacteriological examination of sinus secretion. As in classical puncture of maxillary sinus the permanent drainage play a diagnostic and therapeutic roles. The permanent drainage of maxillary sinus allow for inflow of oxygen into sinus and protect from anaerobic infection. The fact that puncture needle is pushed to a depth of only 1 cm greatly reduces the risk of injuring neighbouring structures. This method enables puncture of maxillary sinus with minimum trauma and hardly any pain.

Adult↗

[Use of "rinoflow" inhalation in treatment of paranasal sinusitis].

The inflammatory pathologies of the ENT tract are often characterized by presence of catarral, mucous-purulent and crusty secretions. In such cases, an efficient therapy has to change the dense secretions as first and then remove them. "Rinoflow" is a compressor-micronizer chamber system specially designed for treatment of affections of upper respiratory tract. We used Rinflow in treatment of 62 patients (23 female and 39 male, mean age 42.7 years) with chronic paranasal sinusitis. The results of treatment were estimated by patients, physicians and X-ray examinations. We observed in 37 patients (59.7%) good results after treatment. The use of "rinoflow" was practically effected when the secretions were blocking the natural ostium of paranasal sinuses.

Adolescent↗

[Laser surgery and interferon in the treatment of laryngeal papilloma].

The laryngeal papilloma is very doubtful disease in children. The unknown etiology cause that there wasn't complete radical method in the treatment of laryngeal papilloma. Authors presented a case of 11 years old girl with recurrent laryngeal papilloma, who was treated twice with laser microsurgery without successful results. The 6 months application of interferon alfa after third laser microsurgery resulted in more than one year of remission of the disease.

Child↗

[Endoscopic surgery of the sinus: own experiences].

In the Clinic of Otolaryngology Central Clinical Hospital Military School of Medicine in Warsaw in years 1992-1996 there were performed 187 endoscopic operations of nose and paranasal sinuses. Authors analised own material paying particular attention to indications, benefits and failures of these operations. Authors postulate that indications for clinical diagnostic and therapeutic procedures of this technique should be considerably extended in diseases of nose and paranasal sinuses. The application of endoscopic sinus surgery in our Clinic decreased the number of more extended operations of paranasal sinuses.

Adolescent↗

[The role of aeroallergens monitoring in the allergological practice].

A physician wanting to help his hay fever patient efficiently needs to know the causative agent in detail. High qualitative and quantitative variability in certain years creates the necessity of constant pollen count monitoring. Information on current trends is helpful to doctors in their diagnostic and prophylactic procedures as well as in efficient treatment planning.

Allergens↗