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Biomedical subjects

A Lewandowska

Publications and source records attributed to A Lewandowska.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Synthesis and pharmacological properties of decahydro-5H-pyrido [1',2'; 5,1]imidazo[3,4-a]-beta-carbolines.

Cyclic aminals (1-4) including a form of decahydro-5H-pyrido[1', 2'; 5, 1] imidazo [3, 4-a]-beta-carboline were obtained by treating erythro 1-(2'-piperidyl)-1,2,3,4-tetrahydro-beta-carboline with aldehydes. The central action of compounds 1-4 has been investigated using behavioral tests in mice and rats. The most active aminal was a phenyl derivative 4, which showed an anticonvulsive activity in the maximal electroshock seizure test. The overall activity of compound 4 was less potent than that of phenytoin.

Animals↗
PubMedDate not supplied

Synthesis of 3-(4,4-dimethyl-2-piperidon-6-yl)methyl-2-pyrazoline derivatives.

The results of studies of condensation of 1-(4,4-dimethyl-2-piperidon-6-yl)-4-phenyl-3-buten-2-one and its derivatives substituted in the benzene ring (R = 4-CH3 and R = 4-Cl) with hydrazine and its methyl or phenyl derivative are described. Compounds 2a, 2c and 2g were tested for their possible action on the central nervous system. Two drugs: 2c and 2g decreased locomotor activity. None of the examined compounds inhibited the reserpine-induced hypothermia, 5-HT syndrome and convulsions induced by pentetrazole in mice. Compound 2c injected only intraperitoneally depressed the number of the writhing episodes induced by p-phenylbenzoquinone.

5-Hydroxytryptophan↗
PubMedDate not supplied

The central action of carbamazepine as a potential antidepressant drug.

Carbamazepine (CBZ) was studied in mice and rats with regard to its antidepressant activity. CBZ did not counteract hypothermia and ptosis induced by reserpine, hypothermia evoked by apomorphine, or sedation and hypothermia induced by clonidine. CBZ shortened the immobility time in the behavioral despair test in rats (but not in mice). It attenuated hyperactivity evoked by d-amphetamine, not affecting stereotypy induced by that drug. CBZ inhibited head twitches evoked by 5-HTP, as well as the hind limb flexor reflex of the spinal rat, having no effect on its stimulation by noradrenaline and 5-hydroxytryptamine agonists. CBZ administered repeatedly did not enhance clonidine aggressiveness or d-amphetamine locomotor hyperactivity, acting differently than many antidepressant drugs. The obtained results indicate that CBZ is not similar in its action to typical and many atypical antidepressants.

Aggression↗
PubMedDate not supplied

Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes.

Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine-stimulated hind paw flexor reflex test in rats.

5-Hydroxytryptophan↗
PubMedDate not supplied

The effect of budipine on the central serotoninergic system.

Budipine, a new potential antiparkinsonian drug, did not affect or--in higher doses--inhibited the flexor reflex in spinal rats, having no influence on LSD- or fenfluramine-induced flexor-reflex stimulation. It did not affect the body temperature either of the rat kept at a high ambient temperature or of the rabbit in a normothermic surroundings. It weakened fenfluramine hyperthermia in heat-adapted rats, but not in rabbits. Only in high doses budipine weakened tryptamine-induced clonic convulsions of rat forepaws. Budipine partially prevented fenfluramine-induced depletion of whole brain 5-hydroxytryptamine. The above results show that budipine demonstrates some properties of 5-HT uptake inhibitors.

Animals↗