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Biomedical subjects

A Levin

Publications and source records attributed to A Levin.

At least 199 records · Page 11Linked to original sources
PubMed1978

Modern psychiatry in a general hospital.

An analysis of 3526 patients referred to the psychiatric unit of a general hospital from 1 January 1975 to 31 December 1977 is presented. The method of classification used was that of the revised Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association and the 8th revision of the International Classification of Diseases. A striking feature of this survey was the low prevalence of schizophrenia (9,8%). A noticeable trend was that more patients seemed to have less incapacitating psychiatric conditions. An exciting new facet of psychiatry is the increasing number of patients without apparent psychiatric illness who are referred to the unit. These include patients referred by colleagues for preliminary screening before organ transplantation, sex change operations, cosmetic surgery, sterilization and termination of pregnancy. Recommendations are made with regard to the role of psychiatric units in general hospitals.

Humans↗
PubMed1978

Heat-shock DNA homology in distantly related species of Drosophila.

Polytene chromosomes of D. melanogaster and D. virilis were hybridized in situ with 125I labeled mRNA isolated from polysomes of D. melanogaster tissue culture cells incubated at 37 degrees C. 125I mRNA hybridized preferentially with subdivisions 87A and 87Cl of the D. melanogaster 3R chromosome; grains were also observed at regions 93D, 95D and over the chromocenter. A considerable cross hybridization of this mRNA with D. virilis polytene chromosomes was observed. The 29C region of the D. virilis second chromosome was the main site of hybridization. Significant grain numbers also appeared in region 20F of the same chromosome. The two regions mentioned belong to heat shock loci in the latter species. Based on label intensity we conclude that region 29C of D. virilis contains DNA sequences retaining molecular homology with those at subdivisions 87A and 87Cl of D. melanogaster. SDS-polyacrylamide gel electrophoresis revealed similar distributions of heat shock proteins in the two species studied.

Animals↗
PubMed1978

The use of chlorazepate for premedication on the night before surgery.

Chlorazepate, a long-acting benzodiazepine, allayed anxiety before operation, being superior to placebo in a double-blind study in which the drug was given the night before surgery. Long-term relief of apprehension before surgery by the administration of chlorazepate, combined with a narcotic analgesic when indicated, is advocated.

Adult↗
PubMed1978

Surgical restraint in the management of hepatic injury: a review of Charity Hospital Experience.

We have reviewed 546 cases of hepatic trauma treated from 1964 through 1976: 76 patients with blunt injury, 308 with gunshot wounds, and 162 with stab wounds. Hypovolemic shock was present in 22%. The overall mortality was 10%. Stab wounds had a negligible mortality of 0.6%, whereas 12% of patients with gunshots and 28% of patients with blunt trauma died. Management followed the general principles of control of hemorrhage and conservative debridement with avoidance of major procedures. Eighty-four per cent of patients required only drainage or suture and drainage. Only 8% had extensive debridement. An additional 5% (31 patients) underwent hepatic lobectomy. Hepatic artery ligation, as an isolated procedure, was not employed. Common bile duct cannulation was employed only six times. Mortality among patients treated by suture or drainage was 5.4%. When resection was required, a 52% mortality resulted. We conclude that the principles of conservative surgical treatment can give a satisfactory survival rate in most hepatic trauma.

Adolescent↗
PubMed1976

Cannabis-related acute brain syndrome following major trauma.

An acute brain syndrome in a cannabis-dependent patient, who sustained multiple injuries, is described. Points of difference between this syndrome and delirium tremens are discussed. Recommendations are made regarding the treatment of this complication, which may follow multiple injuries or operative procedures.

Acute Disease↗
PubMed1975

Alpha-Fetoprotein levels in normal males from seven ethnic groups with different hepatocellular carcinoma risks.

Alpha-Fetoprotein (AFP) levels of 1,335 males (15 years and older) of seven ethnic groups (Chinese, Indians, and Malays from Singapore, Caucasians from Lyon, and Blacks from Nairobi, forest, and the savanna region of the Ivory Coast) were determined by radioimmunoassay. A few elevated levels (up to 30 nanounits/ml) were detected in some normal individuals, especially in the older age-groups. In addition, there was a systematic age-dependency of AFP levels particularly evident in the groups from Singapore-Lyon, in which there was a 50% AFP increase between the ages of 20 and 40. Comparison between Africans on the one hand and people from Singapore-Lyon on the other hand revealed highly significant differences (p less than 0.001), especially in the younger groups, whereas Chinese, Malays, and Indians from Singapore had very similar AFP pattern; this suggests an important role for environmental factors in the regulation of AFP levels. The age dependency of the presumed effect of environmental factors is in keeping with experimental data showing that young animals respond more vigorously to AFP-stimulating factors. Although the incidence of hepatocellular carcinoma (HCC) differs in the three Singapore groups (the highest in Chinese and the lowest in Indians), no relationship was observed in this study between mean AFP level and HCC incidence in Singapore.

Adult↗
PubMed1975

Glomerular antigen complexes associated with transitional cell carcinoma.

An immunofluorescent pattern consistent with glomerular complexes of tumor antigen bound to IgM antibody has been observed in a patient without clinical or pathologic evidence of renal disease. The findings support the thesis that tumors may shed antigen capable of eliciting an immune response which may or may not be associated with clinically evident glomerulopathy.

Aged↗