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Biomedical subjects

A Leth

Publications and source records attributed to A Leth.

80 records · Page 5Linked to original sources
PubMed1968

High haemoglobin values during medical treatment of hypertension.

In 123 patients with arterial hypertension the haemoglobin values were determined before and during long-term antihypertensive drug treatment. The haemoglobin values found before treatment did not differ from those found in the normal population. In both sexes the haemoglobin values showed a significant increase after prolonged treatment. In males the average values rose from 15.1 to 16.7 g./100 ml., and in females from 13.96 to 14.82 g./100 ml. The increase in the haemoglobin concentration does not seem to be clearly correlated to the duration of treatment or to the decrease produced in mean blood pressure. On the other hand, the increase in haemoglobin depended to some extent on the nature of treatment. Diuretics alone resulted in a moderate increase only, whereas diuretics in combination with other antihypertensive drugs produced a more pronounced increase in haemoglobin values.

Adult↗
PubMedDate not supplied

Changes in plasma and extracellular fluid volume during long-term treatment with alpha-methyldopa in 11 thiazide-treated patients with essential hypertension.

In eleven patients with essential hypertension, plasma volume (T-1824) (PV), extracellular fluid volume (82Br-distribution space) (ECFV), blood pressure (BP) and the ratio plasma to interstitial fluid volume (PV/IF) have been determined three times before treatment, after more than two months of thiazide treatment and after three and six months of combined thiazide-alpha-methyldopa (AMD) therapy. During combined treatment, PV/IF showed a significant increase, whereas PV and ECFV did not change significantly. Compared to values during thiazide therapy, PV and PV/IF increased, whereas ECFV was unchanged. BP was reduced significantly after thiazide treatment and showed a further significant fall when AMD was added. Based on the results and a review of the literature, it is concluded that AMD acts by interfering with the normal sympathetic activity, thereby producing a reduced venomotor tone and increased venous capacity. The concomitant reduced venous return of blood to the heart is suggested to contribute to the antihypertensive effect of AMD by means of a decreased cardiac output.

Aged↗